ID   PRPR_SALTY              Reviewed;         541 AA.
AC   P74839;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Propionate catabolism operon regulatory protein;
GN   Name=prpR; OrderedLocusNames=STM0367;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=9006051; DOI=10.1128/jb.179.3.928-940.1997;
RA   Horswill A.R., Escalante-Semerena J.C.;
RT   "Propionate catabolism in Salmonella typhimurium LT2: two divergently
RT   transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a
RT   member of the sigma-54 family of activators, and the prpBCDE genes
RT   constitute an operon.";
RL   J. Bacteriol. 179:928-940(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in the transcriptional regulation of the propionate
CC       catabolism operon.
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DR   EMBL; U51879; AAC44813.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19321.1; -; Genomic_DNA.
DR   RefSeq; NP_459362.1; NC_003197.2.
DR   RefSeq; WP_000205278.1; NC_003197.2.
DR   AlphaFoldDB; P74839; -.
DR   SMR; P74839; -.
DR   STRING; 99287.STM0367; -.
DR   PaxDb; P74839; -.
DR   EnsemblBacteria; AAL19321; AAL19321; STM0367.
DR   GeneID; 1251886; -.
DR   KEGG; stm:STM0367; -.
DR   PATRIC; fig|99287.12.peg.388; -.
DR   HOGENOM; CLU_000445_8_5_6; -.
DR   OMA; IMLYARS; -.
DR   PhylomeDB; P74839; -.
DR   BioCyc; SENT99287:STM0367-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012704; Sig_transdc_resp-reg_PrpR.
DR   InterPro; IPR010524; Sig_transdc_resp-reg_PrpR_N.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF06506; PrpR_N; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02329; propionate_PrpR; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   4: Predicted;
KW   ATP-binding; DNA-binding; Nucleotide-binding; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..541
FT                   /note="Propionate catabolism operon regulatory protein"
FT                   /id="PRO_0000081325"
FT   DOMAIN          221..464
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   DNA_BIND        513..532
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         321..330
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
SQ   SEQUENCE   541 AA;  60338 MW;  6E231219FFCFBDC6 CRC64;
     MTTAHSAPRD NSDKPVIWTV SVTRLFELFR DISLEFDHLA TITPIQLGFE KAVTYIRKKL
     ATERCDAIIA AGSNGAYLKS RLSIPVILIK PSGFDVLQAL AKAGKLTSSI GIVTYQETIP
     ALLAFQKTFH LRLEQRSYVT EEDARGQINE LKANGIEAVV GAGLITDLAE EAGMTAIFIY
     SAATVRQAFH DALDMTRLTR RQRVDYPSGK GLQTRYELGD IRGQSPQMEQ LRQTITLYAR
     SRAAVLIQGE TGTGKELAAQ AIHQTFFHRQ PHRQNKPSPP FVAVNCGAIT ESLLEAELFG
     YEEGAFTGSR RGGRAGLFEI AHGGTLFLDE IGEMPLPLQT RLLRVLEEKA VTRVGGHQPI
     PVDVRVISAT HCDLDREIMQ GRFRPDLFYR LSILRLTLPP LRERQADILP LAESFLKQSL
     AAMEIPFTES IRHGLTQCQP LLLAWRWPGN IRELRNMMER LALFLSVDPA PTLDRQFMRQ
     LLPELMVNTA ELTPSTVDAN ALQDVLARFK GDKTAAARYL GISRTTLWRR LKAGAKDQSD
     N