PRR11_MOUSE
ID PRR11_MOUSE Reviewed; 368 AA.
AC Q8BHE0; B2KGQ3; Q3V3H1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Proline-rich protein 11;
GN Name=Prr11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a critical role in cell cycle progression.
CC {ECO:0000250|UniProtKB:Q96HE9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96HE9}.
CC -!- PTM: Ubiquitinated. Rapidly degraded by the proteasome; degradation may
CC involve FBXW7-specific phosphorylated phosphodegron motifs.
CC {ECO:0000250|UniProtKB:Q96HE9}.
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DR EMBL; AK040348; BAE20577.1; -; mRNA.
DR EMBL; AK047463; BAC33065.1; -; mRNA.
DR EMBL; AK083651; BAC38983.1; -; mRNA.
DR EMBL; AL713917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU407131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU468043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC023918; AAH23918.1; -; mRNA.
DR CCDS; CCDS25208.1; -.
DR RefSeq; NP_780772.1; NM_175563.5.
DR AlphaFoldDB; Q8BHE0; -.
DR SMR; Q8BHE0; -.
DR BioGRID; 234820; 1.
DR IntAct; Q8BHE0; 1.
DR STRING; 10090.ENSMUSP00000060803; -.
DR iPTMnet; Q8BHE0; -.
DR PhosphoSitePlus; Q8BHE0; -.
DR EPD; Q8BHE0; -.
DR MaxQB; Q8BHE0; -.
DR PaxDb; Q8BHE0; -.
DR PeptideAtlas; Q8BHE0; -.
DR PRIDE; Q8BHE0; -.
DR ProteomicsDB; 291797; -.
DR Antibodypedia; 18470; 228 antibodies from 18 providers.
DR Ensembl; ENSMUST00000051395; ENSMUSP00000060803; ENSMUSG00000020493.
DR GeneID; 270906; -.
DR KEGG; mmu:270906; -.
DR UCSC; uc007kth.2; mouse.
DR CTD; 55771; -.
DR MGI; MGI:2444496; Prr11.
DR VEuPathDB; HostDB:ENSMUSG00000020493; -.
DR eggNOG; ENOG502RZVF; Eukaryota.
DR GeneTree; ENSGT00510000046704; -.
DR HOGENOM; CLU_055832_0_0_1; -.
DR InParanoid; Q8BHE0; -.
DR OMA; PMHITVK; -.
DR OrthoDB; 1169838at2759; -.
DR PhylomeDB; Q8BHE0; -.
DR TreeFam; TF333428; -.
DR BioGRID-ORCS; 270906; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Prr11; mouse.
DR PRO; PR:Q8BHE0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BHE0; protein.
DR Bgee; ENSMUSG00000020493; Expressed in cleaving embryo and 111 other tissues.
DR Genevisible; Q8BHE0; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISO:MGI.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..368
FT /note="Proline-rich protein 11"
FT /id="PRO_0000243944"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 293..299
FT /note="Phosphodegron"
FT MOTIF 304..312
FT /note="D-box"
FT MOTIF 324..326
FT /note="KEN box"
FT MOTIF 333..338
FT /note="Phosphodegron"
FT COMPBIAS 1..19
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96HE9"
FT MOD_RES 295
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96HE9"
FT MOD_RES 299
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96HE9"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96HE9"
FT MOD_RES 354
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96HE9"
FT CONFLICT 206..208
FT /note="PLA -> TLP (in Ref. 1; BAE20577)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="R -> T (in Ref. 1; BAE20577)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 368 AA; 40949 MW; 2C1A6A347E6D50CE CRC64;
MPKYKQRRRK LKAKAKRMSK KKEAAVVSPK LLTPSPPLPE PERVVTSAAD IPQSRNWLRP
SWNLRFPNIK DAINLWTNRA WCIYSCCQTC VAQSLEVLKD ALFPSRVYHR ELHSLKQQLC
VLKRELCKLR ENLKSISENS SCSSCCHKCC PSDKLTTVPA CAPTTNGESQ TVLSSTQPQP
ANHPPSPPPL PPPPPPPPPL PPPPPPLAPL LLRKSGTTKA LQVEPLKKDG PMHITVKDLL
NVKLKKTQSV DERKKLVPSP PEERTPLVTV SDLQHVTLKP NSRVSATRIK NVLITPGKSQ
IDLRKLLRKV QVERSPGGTP LNNKENMDTG TGLTPVMTRA LRRKFQLAHP QSPTQSLPLS
TSSFDEQN
