PRR13_HUMAN
ID PRR13_HUMAN Reviewed; 148 AA.
AC Q9NZ81; Q0V8U0; Q6FIG7; Q6MZP8; Q6NXQ6; Q6PKF9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Proline-rich protein 13;
DE AltName: Full=Taxane-resistance protein;
GN Name=PRR13; Synonyms=TXR1; ORFNames=BM-041;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND ALTERNATIVE SPLICING.
RX PubMed=16847352; DOI=10.1101/gad.1441306;
RA Lih C.-J., Wei W., Cohen S.N.;
RT "Txr1: a transcriptional regulator of thrombospondin-1 that modulates
RT cellular sensitivity to taxanes.";
RL Genes Dev. 20:2082-2095(2006).
CC -!- FUNCTION: Negatively regulates TSP1 expression at the level of
CC transcription. This down-regulation was shown to reduce taxane-induced
CC apoptosis. {ECO:0000269|PubMed:16847352}.
CC -!- INTERACTION:
CC Q9NZ81; Q96CW1: AP2M1; NbExp=3; IntAct=EBI-740924, EBI-297683;
CC Q9NZ81; Q9UQB8: BAIAP2; NbExp=3; IntAct=EBI-740924, EBI-525456;
CC Q9NZ81; Q8N7E2: CBLL2; NbExp=3; IntAct=EBI-740924, EBI-12196065;
CC Q9NZ81; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-740924, EBI-12139335;
CC Q9NZ81; Q15038: DAZAP2; NbExp=3; IntAct=EBI-740924, EBI-724310;
CC Q9NZ81; Q92997: DVL3; NbExp=3; IntAct=EBI-740924, EBI-739789;
CC Q9NZ81; Q01844: EWSR1; NbExp=3; IntAct=EBI-740924, EBI-739737;
CC Q9NZ81; Q8N9E0: FAM133A; NbExp=3; IntAct=EBI-740924, EBI-10268158;
CC Q9NZ81; Q96AE4-2: FUBP1; NbExp=3; IntAct=EBI-740924, EBI-12121668;
CC Q9NZ81; U3KQK0: H2BC15; NbExp=3; IntAct=EBI-740924, EBI-12142839;
CC Q9NZ81; A0A024RA76: hCG_1744368; NbExp=3; IntAct=EBI-740924, EBI-10180729;
CC Q9NZ81; Q14005-2: IL16; NbExp=3; IntAct=EBI-740924, EBI-17178971;
CC Q9NZ81; Q7Z7F0-4: KHDC4; NbExp=3; IntAct=EBI-740924, EBI-9089060;
CC Q9NZ81; Q53G59: KLHL12; NbExp=7; IntAct=EBI-740924, EBI-740929;
CC Q9NZ81; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-740924, EBI-10172150;
CC Q9NZ81; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-740924, EBI-10172290;
CC Q9NZ81; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-740924, EBI-10171774;
CC Q9NZ81; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-740924, EBI-11992140;
CC Q9NZ81; Q3LI72: KRTAP19-5; NbExp=5; IntAct=EBI-740924, EBI-1048945;
CC Q9NZ81; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-740924, EBI-10241353;
CC Q9NZ81; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-740924, EBI-18395721;
CC Q9NZ81; Q3LI64: KRTAP6-1; NbExp=5; IntAct=EBI-740924, EBI-12111050;
CC Q9NZ81; Q3LI66: KRTAP6-2; NbExp=6; IntAct=EBI-740924, EBI-11962084;
CC Q9NZ81; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-740924, EBI-18394498;
CC Q9NZ81; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-740924, EBI-10261141;
CC Q9NZ81; P17931: LGALS3; NbExp=4; IntAct=EBI-740924, EBI-1170392;
CC Q9NZ81; Q6NVH9: LGALS3; NbExp=3; IntAct=EBI-740924, EBI-10187804;
CC Q9NZ81; Q8TBB1: LNX1; NbExp=4; IntAct=EBI-740924, EBI-739832;
CC Q9NZ81; P35548: MSX2; NbExp=3; IntAct=EBI-740924, EBI-6447480;
CC Q9NZ81; P32242: OTX1; NbExp=3; IntAct=EBI-740924, EBI-740446;
CC Q9NZ81; P50542: PEX5; NbExp=3; IntAct=EBI-740924, EBI-597835;
CC Q9NZ81; O15162: PLSCR1; NbExp=3; IntAct=EBI-740924, EBI-740019;
CC Q9NZ81; P25788: PSMA3; NbExp=3; IntAct=EBI-740924, EBI-348380;
CC Q9NZ81; P61289: PSME3; NbExp=6; IntAct=EBI-740924, EBI-355546;
CC Q9NZ81; A0AV96: RBM47; NbExp=3; IntAct=EBI-740924, EBI-2823850;
CC Q9NZ81; O00560: SDCBP; NbExp=3; IntAct=EBI-740924, EBI-727004;
CC Q9NZ81; Q9H190: SDCBP2; NbExp=7; IntAct=EBI-740924, EBI-742426;
CC Q9NZ81; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-740924, EBI-12275818;
CC Q9NZ81; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-740924, EBI-10268630;
CC Q9NZ81; P30626: SRI; NbExp=3; IntAct=EBI-740924, EBI-750459;
CC Q9NZ81; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-740924, EBI-11064654;
CC Q9NZ81; O95379: TNFAIP8; NbExp=6; IntAct=EBI-740924, EBI-1049336;
CC Q9NZ81; Q15645: TRIP13; NbExp=3; IntAct=EBI-740924, EBI-358993;
CC Q9NZ81; Q08AM6: VAC14; NbExp=6; IntAct=EBI-740924, EBI-2107455;
CC Q9NZ81; Q8TBK6: ZCCHC10; NbExp=4; IntAct=EBI-740924, EBI-597063;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16847352}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NZ81-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NZ81-2; Sequence=VSP_024394;
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DR EMBL; AF217517; AAF67628.1; -; mRNA.
DR EMBL; CR533459; CAG38490.1; -; mRNA.
DR EMBL; BX640962; CAE45980.1; -; mRNA.
DR EMBL; CH471054; EAW96703.1; -; Genomic_DNA.
DR EMBL; BC014257; AAH14257.1; -; mRNA.
DR EMBL; BC016064; AAH16064.1; -; mRNA.
DR EMBL; BC066943; AAH66943.1; -; mRNA.
DR EMBL; BK005847; DAA05782.1; -; mRNA.
DR CCDS; CCDS31811.1; -. [Q9NZ81-2]
DR CCDS; CCDS44899.1; -. [Q9NZ81-1]
DR RefSeq; NP_001005354.1; NM_001005354.2. [Q9NZ81-2]
DR RefSeq; NP_060927.1; NM_018457.3. [Q9NZ81-1]
DR AlphaFoldDB; Q9NZ81; -.
DR SMR; Q9NZ81; -.
DR BioGRID; 119965; 55.
DR IntAct; Q9NZ81; 51.
DR MINT; Q9NZ81; -.
DR STRING; 9606.ENSP00000412064; -.
DR iPTMnet; Q9NZ81; -.
DR PhosphoSitePlus; Q9NZ81; -.
DR BioMuta; PRR13; -.
DR DMDM; 74734721; -.
DR MassIVE; Q9NZ81; -.
DR PaxDb; Q9NZ81; -.
DR PeptideAtlas; Q9NZ81; -.
DR PRIDE; Q9NZ81; -.
DR Antibodypedia; 43374; 55 antibodies from 16 providers.
DR DNASU; 54458; -.
DR Ensembl; ENST00000379786.8; ENSP00000369112.4; ENSG00000205352.11. [Q9NZ81-2]
DR Ensembl; ENST00000429243.7; ENSP00000412064.2; ENSG00000205352.11. [Q9NZ81-1]
DR Ensembl; ENST00000549135.1; ENSP00000447777.1; ENSG00000205352.11. [Q9NZ81-1]
DR Ensembl; ENST00000549581.5; ENSP00000448153.1; ENSG00000205352.11. [Q9NZ81-2]
DR Ensembl; ENST00000549924.5; ENSP00000448761.1; ENSG00000205352.11. [Q9NZ81-1]
DR GeneID; 54458; -.
DR KEGG; hsa:54458; -.
DR MANE-Select; ENST00000429243.7; ENSP00000412064.2; NM_018457.4; NP_060927.1.
DR UCSC; uc001scy.5; human. [Q9NZ81-1]
DR CTD; 54458; -.
DR DisGeNET; 54458; -.
DR GeneCards; PRR13; -.
DR HGNC; HGNC:24528; PRR13.
DR HPA; ENSG00000205352; Low tissue specificity.
DR MIM; 610459; gene.
DR neXtProt; NX_Q9NZ81; -.
DR OpenTargets; ENSG00000205352; -.
DR PharmGKB; PA143485583; -.
DR VEuPathDB; HostDB:ENSG00000205352; -.
DR eggNOG; ENOG502R4RR; Eukaryota.
DR GeneTree; ENSGT00730000111608; -.
DR HOGENOM; CLU_2432475_0_0_1; -.
DR InParanoid; Q9NZ81; -.
DR OMA; VNPACPP; -.
DR PathwayCommons; Q9NZ81; -.
DR SignaLink; Q9NZ81; -.
DR BioGRID-ORCS; 54458; 238 hits in 1074 CRISPR screens.
DR ChiTaRS; PRR13; human.
DR GenomeRNAi; 54458; -.
DR Pharos; Q9NZ81; Tbio.
DR PRO; PR:Q9NZ81; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NZ81; protein.
DR Bgee; ENSG00000205352; Expressed in mucosa of transverse colon and 96 other tissues.
DR ExpressionAtlas; Q9NZ81; baseline and differential.
DR Genevisible; Q9NZ81; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..148
FT /note="Proline-rich protein 13"
FT /id="PRO_0000243946"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 7..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_024394"
FT CONFLICT 56
FT /note="P -> S (in Ref. 2; CAG38490)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="P -> L (in Ref. 5; AAH66943)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="S -> P (in Ref. 3; CAE45980)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 15385 MW; 56BFEE6A15935A2E CRC64;
MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG NPAFPPGGPP
HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG PAVIVDKKMQ KKMKKAHKKM
HKHQKHHKYH KHGKHSSSSS SSSSSDSD
