PRR13_MOUSE
ID PRR13_MOUSE Reviewed; 137 AA.
AC Q9CQJ5; Q3U3U4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Proline-rich protein 13;
GN Name=Prr13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Kidney, Small intestine, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negatively regulates TSP1 expression at the level of
CC transcription. This down-regulation was shown to reduce taxane-induced
CC apoptosis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK002430; BAB22096.1; -; mRNA.
DR EMBL; AK003850; BAB23035.1; -; mRNA.
DR EMBL; AK008611; BAB25776.1; -; mRNA.
DR EMBL; AK008894; BAB25957.1; -; mRNA.
DR EMBL; AK154583; BAE32691.1; -; mRNA.
DR EMBL; BC016234; AAH16234.1; -; mRNA.
DR CCDS; CCDS27883.1; -.
DR RefSeq; NP_001164382.1; NM_001170911.1.
DR RefSeq; NP_079661.1; NM_025385.3.
DR AlphaFoldDB; Q9CQJ5; -.
DR SMR; Q9CQJ5; -.
DR STRING; 10090.ENSMUSP00000023810; -.
DR PhosphoSitePlus; Q9CQJ5; -.
DR PaxDb; Q9CQJ5; -.
DR PRIDE; Q9CQJ5; -.
DR DNASU; 66151; -.
DR Ensembl; ENSMUST00000023810; ENSMUSP00000023810; ENSMUSG00000023048.
DR Ensembl; ENSMUST00000164688; ENSMUSP00000130498; ENSMUSG00000023048.
DR Ensembl; ENSMUST00000164957; ENSMUSP00000125784; ENSMUSG00000023048.
DR Ensembl; ENSMUST00000171245; ENSMUSP00000132636; ENSMUSG00000023048.
DR GeneID; 66151; -.
DR KEGG; mmu:66151; -.
DR UCSC; uc007xvr.2; mouse.
DR CTD; 54458; -.
DR MGI; MGI:1913401; Prr13.
DR VEuPathDB; HostDB:ENSMUSG00000023048; -.
DR eggNOG; ENOG502R4RR; Eukaryota.
DR GeneTree; ENSGT00730000113467; -.
DR HOGENOM; CLU_140437_0_0_1; -.
DR InParanoid; Q9CQJ5; -.
DR OMA; VNPACPP; -.
DR BioGRID-ORCS; 66151; 8 hits in 72 CRISPR screens.
DR ChiTaRS; Prr13; mouse.
DR PRO; PR:Q9CQJ5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9CQJ5; protein.
DR Bgee; ENSMUSG00000023048; Expressed in granulocyte and 254 other tissues.
DR ExpressionAtlas; Q9CQJ5; baseline and differential.
DR Genevisible; Q9CQJ5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..137
FT /note="Proline-rich protein 13"
FT /id="PRO_0000243947"
FT REGION 26..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..125
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 134
FT /note="S -> SS (in Ref. 1; BAE32691)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 137 AA; 14208 MW; 84B77307B64B895E CRC64;
MWNPNAGPNP YPPQVVCPGG SNPACPPPLN PAFPPGPCPP GIPQGNPAFP PCRPPYPVPQ
PGCPGYQPSG PYPPPYPPPA PGMCPVNPPA PGMVGPGIVI DKKTRKKMKK AHKKSHKHHK
HGKHSSSSSS SSSSDSD
