PRR15_HUMAN
ID PRR15_HUMAN Reviewed; 129 AA.
AC Q8IV56;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Proline-rich protein 15;
GN Name=PRR15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have a role in proliferation and/or differentiation.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IV56; G5E9A7: DMWD; NbExp=3; IntAct=EBI-8787485, EBI-10976677;
CC Q8IV56; D3DTS7: PMP22; NbExp=3; IntAct=EBI-8787485, EBI-25882629;
CC Q8IV56; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-8787485, EBI-5235340;
CC -!- SIMILARITY: Belongs to the PRR15 family. {ECO:0000305}.
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DR EMBL; BC029131; AAH29131.1; -; mRNA.
DR CCDS; CCDS5421.1; -.
DR RefSeq; NP_001316925.1; NM_001329996.1.
DR RefSeq; NP_001316926.1; NM_001329997.1.
DR RefSeq; NP_787083.1; NM_175887.2.
DR RefSeq; XP_011513500.1; XM_011515198.1.
DR RefSeq; XP_011513501.1; XM_011515199.1.
DR AlphaFoldDB; Q8IV56; -.
DR BioGRID; 128786; 11.
DR IntAct; Q8IV56; 4.
DR STRING; 9606.ENSP00000317836; -.
DR iPTMnet; Q8IV56; -.
DR PhosphoSitePlus; Q8IV56; -.
DR BioMuta; PRR15; -.
DR EPD; Q8IV56; -.
DR jPOST; Q8IV56; -.
DR MassIVE; Q8IV56; -.
DR MaxQB; Q8IV56; -.
DR PaxDb; Q8IV56; -.
DR PeptideAtlas; Q8IV56; -.
DR PRIDE; Q8IV56; -.
DR ProteomicsDB; 70664; -.
DR Antibodypedia; 44229; 111 antibodies from 16 providers.
DR DNASU; 222171; -.
DR Ensembl; ENST00000319694.3; ENSP00000317836.2; ENSG00000176532.4.
DR GeneID; 222171; -.
DR KEGG; hsa:222171; -.
DR MANE-Select; ENST00000319694.3; ENSP00000317836.2; NM_175887.3; NP_787083.1.
DR UCSC; uc003tac.1; human.
DR CTD; 222171; -.
DR DisGeNET; 222171; -.
DR GeneCards; PRR15; -.
DR HGNC; HGNC:22310; PRR15.
DR HPA; ENSG00000176532; Tissue enhanced (cervix, intestine, stomach).
DR MIM; 618344; gene.
DR neXtProt; NX_Q8IV56; -.
DR OpenTargets; ENSG00000176532; -.
DR PharmGKB; PA162400154; -.
DR VEuPathDB; HostDB:ENSG00000176532; -.
DR eggNOG; ENOG502S7ST; Eukaryota.
DR GeneTree; ENSGT00940000154534; -.
DR HOGENOM; CLU_164864_0_0_1; -.
DR InParanoid; Q8IV56; -.
DR OMA; SSPWWKS; -.
DR OrthoDB; 1534656at2759; -.
DR PhylomeDB; Q8IV56; -.
DR TreeFam; TF333189; -.
DR PathwayCommons; Q8IV56; -.
DR SignaLink; Q8IV56; -.
DR BioGRID-ORCS; 222171; 9 hits in 1063 CRISPR screens.
DR ChiTaRS; PRR15; human.
DR GenomeRNAi; 222171; -.
DR Pharos; Q8IV56; Tbio.
DR PRO; PR:Q8IV56; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IV56; protein.
DR Bgee; ENSG00000176532; Expressed in mucosa of transverse colon and 128 other tissues.
DR ExpressionAtlas; Q8IV56; baseline and differential.
DR Genevisible; Q8IV56; HS.
DR InterPro; IPR028237; PRR15.
DR PANTHER; PTHR14581; PTHR14581; 1.
DR Pfam; PF15321; ATAD4; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..129
FT /note="Proline-rich protein 15"
FT /id="PRO_0000271109"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 115
FT /note="P -> S (in dbSNP:rs10271996)"
FT /id="VAR_059710"
SQ SEQUENCE 129 AA; 13715 MW; 0B100677D003D64A CRC64;
MADSGDAGSS GPWWKSLTNS RKKSKEAAVG VPPPAQPAPG EPTPPAPPSP DWTSSSRENQ
HPNLLGGAGE PPKPDKLYGD KSGSSRRNLK ISRSGRFKEK RKVRATLLPE AGRSPEEAGF
PGDPHEDKQ
