PRR15_MOUSE
ID PRR15_MOUSE Reviewed; 122 AA.
AC Q9D1T5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Proline-rich protein 15;
GN Name=Prr15; Synonyms=G90;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=10333519; DOI=10.1016/s0378-1119(99)00120-1;
RA Krause R., Hemberger M., Himmelbauer H., Kalscheuer V., Fundele R.H.;
RT "Identification and characterization of G90, a novel mouse RNA that lacks
RT an extensive open reading frame.";
RL Gene 232:35-42(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12768423; DOI=10.1007/s00429-003-0330-9;
RA Meunier D., Peters T., Luttges A., Curfs J., Fundele R.;
RT "Preferential expression of the G90 gene in post-mitotic cells during mouse
RT embryonic development.";
RL Anat. Embryol. (Berl.) 207:109-117(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May have a role in proliferation and/or differentiation.
CC {ECO:0000269|PubMed:12768423}.
CC -!- TISSUE SPECIFICITY: Exhibits a cell type specific expression pattern
CC only in the small and large intestine and in the testis. Along the
CC intestinal tract expression is restricted to the non-proliferating
CC epithelial cells surrounding the villi and no expression is found in
CC the intestinal crypts, where proliferation occurs. In the testis, it is
CC detected only in post-mitotic secondary spermatocytes.
CC {ECO:0000269|PubMed:12768423}.
CC -!- DEVELOPMENTAL STAGE: Expressed in specific structures of the developing
CC head, namely the brain, inner and middle ear, olfactory epithelium,
CC vomeronasal organ, nasopharynx, oropharynx, papillae of the tongue and
CC oral cavity, pituitary gland and epiglottis.
CC {ECO:0000269|PubMed:12768423}.
CC -!- SIMILARITY: Belongs to the PRR15 family. {ECO:0000305}.
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DR EMBL; AJ132433; CAD45579.1; -; mRNA.
DR EMBL; AK021401; BAB32398.1; -; mRNA.
DR CCDS; CCDS20155.1; -.
DR RefSeq; NP_084300.1; NM_030024.2.
DR AlphaFoldDB; Q9D1T5; -.
DR BioGRID; 219086; 5.
DR STRING; 10090.ENSMUSP00000049549; -.
DR iPTMnet; Q9D1T5; -.
DR PhosphoSitePlus; Q9D1T5; -.
DR MaxQB; Q9D1T5; -.
DR PaxDb; Q9D1T5; -.
DR PRIDE; Q9D1T5; -.
DR ProteomicsDB; 291668; -.
DR Antibodypedia; 44229; 111 antibodies from 16 providers.
DR DNASU; 78004; -.
DR Ensembl; ENSMUST00000059138; ENSMUSP00000049549; ENSMUSG00000045725.
DR GeneID; 78004; -.
DR KEGG; mmu:78004; -.
DR UCSC; uc009bzu.1; mouse.
DR CTD; 222171; -.
DR MGI; MGI:1925254; Prr15.
DR VEuPathDB; HostDB:ENSMUSG00000045725; -.
DR eggNOG; ENOG502S7ST; Eukaryota.
DR GeneTree; ENSGT00940000154534; -.
DR HOGENOM; CLU_164864_0_0_1; -.
DR InParanoid; Q9D1T5; -.
DR OMA; SSPWWKS; -.
DR OrthoDB; 1534656at2759; -.
DR PhylomeDB; Q9D1T5; -.
DR TreeFam; TF333189; -.
DR BioGRID-ORCS; 78004; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D1T5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D1T5; protein.
DR Bgee; ENSMUSG00000045725; Expressed in vestibular epithelium and 154 other tissues.
DR ExpressionAtlas; Q9D1T5; baseline and differential.
DR Genevisible; Q9D1T5; MM.
DR InterPro; IPR028237; PRR15.
DR PANTHER; PTHR14581; PTHR14581; 1.
DR Pfam; PF15321; ATAD4; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..122
FT /note="Proline-rich protein 15"
FT /id="PRO_0000271110"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 122 AA; 13655 MW; EBB8130F62FF640B CRC64;
MADSGGSSPW WKSLTRKKSK EVTVGVQPQV RPETGQEPSP PHSDRTSSLP ENQHSNILGD
PGESLRSDKL CEEKTGNSRR NLKISRSGRF KEKRKMRATL LPEGDKSPEE ADFPDDPQED
KQ
