PRR18_HUMAN
ID PRR18_HUMAN Reviewed; 295 AA.
AC Q8N4B5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Proline-rich protein 18;
GN Name=PRR18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-136.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AL121956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034775; AAH34775.1; -; mRNA.
DR CCDS; CCDS5291.1; -.
DR RefSeq; NP_787118.2; NM_175922.3.
DR AlphaFoldDB; Q8N4B5; -.
DR STRING; 9606.ENSP00000319590; -.
DR iPTMnet; Q8N4B5; -.
DR PhosphoSitePlus; Q8N4B5; -.
DR BioMuta; PRR18; -.
DR DMDM; 296452871; -.
DR MassIVE; Q8N4B5; -.
DR PaxDb; Q8N4B5; -.
DR PeptideAtlas; Q8N4B5; -.
DR PRIDE; Q8N4B5; -.
DR ProteomicsDB; 71905; -.
DR Antibodypedia; 46754; 99 antibodies from 16 providers.
DR DNASU; 285800; -.
DR Ensembl; ENST00000322583.5; ENSP00000319590.3; ENSG00000176381.6.
DR GeneID; 285800; -.
DR KEGG; hsa:285800; -.
DR MANE-Select; ENST00000322583.5; ENSP00000319590.3; NM_175922.4; NP_787118.2.
DR UCSC; uc003quw.2; human.
DR CTD; 285800; -.
DR GeneCards; PRR18; -.
DR HGNC; HGNC:28574; PRR18.
DR HPA; ENSG00000176381; Tissue enriched (brain).
DR neXtProt; NX_Q8N4B5; -.
DR OpenTargets; ENSG00000176381; -.
DR PharmGKB; PA162400157; -.
DR VEuPathDB; HostDB:ENSG00000176381; -.
DR eggNOG; ENOG502RXBM; Eukaryota.
DR GeneTree; ENSGT00390000002164; -.
DR HOGENOM; CLU_906020_0_0_1; -.
DR InParanoid; Q8N4B5; -.
DR OMA; SCESLCP; -.
DR OrthoDB; 1318168at2759; -.
DR PhylomeDB; Q8N4B5; -.
DR TreeFam; TF337179; -.
DR PathwayCommons; Q8N4B5; -.
DR SignaLink; Q8N4B5; -.
DR BioGRID-ORCS; 285800; 11 hits in 1065 CRISPR screens.
DR GenomeRNAi; 285800; -.
DR Pharos; Q8N4B5; Tdark.
DR PRO; PR:Q8N4B5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8N4B5; protein.
DR Bgee; ENSG00000176381; Expressed in endothelial cell and 84 other tissues.
DR ExpressionAtlas; Q8N4B5; baseline and differential.
DR Genevisible; Q8N4B5; HS.
DR InterPro; IPR031369; PRR18.
DR Pfam; PF15671; PRR18; 1.
PE 2: Evidence at transcript level;
KW Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..295
FT /note="Proline-rich protein 18"
FT /id="PRO_0000307747"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAN7"
FT MOD_RES 83
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAN7"
FT MOD_RES 172
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAN7"
FT MOD_RES 188
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAN7"
FT VARIANT 136
FT /note="C -> S (in dbSNP:rs7757150)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036642"
SQ SEQUENCE 295 AA; 30926 MW; ADEF56F19812FE94 CRC64;
MPFPPMPPPP APAPGAQAAR QLPRRPCAAG DKKKRPPQRP EGLLSSSWPS ATLKRPPARR
GPGLDRTQPP APPGVSPQAL PSRARAPATC APPRPAGSGH SPARTTYAAT SAGTGTTAAG
TSSGAGPCPD SAARFCLNLT PEAVLVIQKR HLEKQLLARP RRPFPSPSAE PRRLLAPCLP
ARAAGPRRGG PASDPDAPPT AGQGRRAPPP GAQLLHGGLQ VPQLSPRPGA LRPMLKVSLL
NERHRYDDVE YEEEPEAVDE GLVRKCTEWL RGVESAAAAR GRAGALDSRR HLSTL
