PRR18_MOUSE
ID PRR18_MOUSE Reviewed; 307 AA.
AC Q6PAN7; Q8BR84; Q8CA32; Q8CBI5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Proline-rich protein 18;
GN Name=Prr18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-108; ARG-186 AND ARG-202, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PAN7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PAN7-2; Sequence=VSP_028816;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29250.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK035939; BAC29250.1; ALT_INIT; mRNA.
DR EMBL; AK039752; BAC30439.1; -; mRNA.
DR EMBL; AK045379; BAC32336.1; -; mRNA.
DR EMBL; BC060190; AAH60190.1; -; mRNA.
DR CCDS; CCDS28382.1; -. [Q6PAN7-1]
DR RefSeq; NP_848889.3; NM_178774.4. [Q6PAN7-1]
DR AlphaFoldDB; Q6PAN7; -.
DR STRING; 10090.ENSMUSP00000069019; -.
DR iPTMnet; Q6PAN7; -.
DR PhosphoSitePlus; Q6PAN7; -.
DR CPTAC; non-CPTAC-3493; -.
DR EPD; Q6PAN7; -.
DR PaxDb; Q6PAN7; -.
DR PeptideAtlas; Q6PAN7; -.
DR PRIDE; Q6PAN7; -.
DR ProteomicsDB; 291669; -. [Q6PAN7-1]
DR ProteomicsDB; 291670; -. [Q6PAN7-2]
DR Antibodypedia; 46754; 99 antibodies from 16 providers.
DR DNASU; 320111; -.
DR Ensembl; ENSMUST00000069742; ENSMUSP00000069019; ENSMUSG00000055945. [Q6PAN7-1]
DR Ensembl; ENSMUST00000163887; ENSMUSP00000127393; ENSMUSG00000055945. [Q6PAN7-1]
DR GeneID; 320111; -.
DR KEGG; mmu:320111; -.
DR UCSC; uc008ajo.1; mouse. [Q6PAN7-1]
DR CTD; 285800; -.
DR MGI; MGI:2443403; Prr18.
DR VEuPathDB; HostDB:ENSMUSG00000055945; -.
DR eggNOG; ENOG502RXBM; Eukaryota.
DR GeneTree; ENSGT00390000002164; -.
DR HOGENOM; CLU_906020_0_0_1; -.
DR InParanoid; Q6PAN7; -.
DR OMA; SCESLCP; -.
DR OrthoDB; 1318168at2759; -.
DR PhylomeDB; Q6PAN7; -.
DR TreeFam; TF337179; -.
DR BioGRID-ORCS; 320111; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Prr18; mouse.
DR PRO; PR:Q6PAN7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6PAN7; protein.
DR Bgee; ENSMUSG00000055945; Expressed in lumbar subsegment of spinal cord and 102 other tissues.
DR ExpressionAtlas; Q6PAN7; baseline and differential.
DR Genevisible; Q6PAN7; MM.
DR InterPro; IPR031369; PRR18.
DR Pfam; PF15671; PRR18; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..307
FT /note="Proline-rich protein 18"
FT /id="PRO_0000307748"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 70
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 108
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 186
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 202
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 1..64
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028816"
FT CONFLICT 143
FT /note="P -> L (in Ref. 1; BAC32336)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="T -> I (in Ref. 1; BAC29250)"
FT /evidence="ECO:0000305"
FT CONFLICT 242..244
FT /note="SLR -> RLG (in Ref. 1; BAC32336)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="S -> T (in Ref. 1; BAC32336)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 32214 MW; D975655BE01CBFEC CRC64;
MLRLLGRVMS FLPMPPPPPP PPPPPRTPGG PAARQLSRRP CAPPAPSPPA ASAAGGEKKR
RPPEMLLSSS WPSATLKRPP VRRGPGLGSG TPQPATSARV PPQPSPGRGG TSTTCSAPRR
VACSHIPAGS TASGTSAGAG AGPDDATRFS LNLTPEAILV IQRRHLEKQL LARPRRPFPT
PSADPRLPLV PCPRTRASTL RRGGPTSVPN APLAVAVSSR PPRASLLPGG LQATLPSPCP
SSLRPVLKVS LLNEKHKYDD EEYEEEVEVV DEGLVRKCTE WLRGVESAAA ARGRTGHLDS
LPHLSTL
