PRR19_HUMAN
ID PRR19_HUMAN Reviewed; 356 AA.
AC A6NJB7; A8K663; B3KW48; Q6P584;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Proline-rich protein 19 {ECO:0000305};
GN Name=PRR19 {ECO:0000312|HGNC:HGNC:33728};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Promotes meiotic crossing over formation through its
CC interaction with CNTD1 by participating in the crossover
CC differentiation step of crossover-specific recombination intermediates.
CC {ECO:0000250|UniProtKB:B2RW88}.
CC -!- SUBUNIT: Interacts with CNTD1. {ECO:0000250|UniProtKB:B2RW88}.
CC -!- INTERACTION:
CC A6NJB7; Q15323: KRT31; NbExp=3; IntAct=EBI-10174045, EBI-948001;
CC A6NJB7; P50222: MEOX2; NbExp=3; IntAct=EBI-10174045, EBI-748397;
CC A6NJB7-2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11998870, EBI-10173507;
CC A6NJB7-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11998870, EBI-3867333;
CC A6NJB7-2; Q15323: KRT31; NbExp=3; IntAct=EBI-11998870, EBI-948001;
CC A6NJB7-2; O76011: KRT34; NbExp=6; IntAct=EBI-11998870, EBI-1047093;
CC A6NJB7-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11998870, EBI-10171774;
CC A6NJB7-2; O75340: PDCD6; NbExp=3; IntAct=EBI-11998870, EBI-352915;
CC A6NJB7-2; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11998870, EBI-492476;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2RW88}.
CC Chromosome {ECO:0000250|UniProtKB:B2RW88}. Note=Co-localized at
CC crossover sites with CNTD1. Localizes on synapsed chromosome only in
CC mid/late pachytene spermatocytes. {ECO:0000250|UniProtKB:B2RW88}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NJB7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NJB7-2; Sequence=VSP_033371;
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DR EMBL; AK124116; BAG54010.1; -; mRNA.
DR EMBL; AK291528; BAF84217.1; -; mRNA.
DR EMBL; AC006486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063021; AAH63021.1; -; mRNA.
DR CCDS; CCDS33036.1; -. [A6NJB7-1]
DR RefSeq; NP_954979.2; NM_199285.2. [A6NJB7-1]
DR RefSeq; XP_005258837.1; XM_005258780.3. [A6NJB7-1]
DR RefSeq; XP_006723217.1; XM_006723154.3. [A6NJB7-1]
DR RefSeq; XP_011525089.1; XM_011526787.1. [A6NJB7-1]
DR RefSeq; XP_011525090.1; XM_011526788.1. [A6NJB7-1]
DR RefSeq; XP_011525091.1; XM_011526789.2. [A6NJB7-1]
DR RefSeq; XP_011525092.1; XM_011526790.2. [A6NJB7-1]
DR AlphaFoldDB; A6NJB7; -.
DR SMR; A6NJB7; -.
DR BioGRID; 129830; 10.
DR IntAct; A6NJB7; 8.
DR STRING; 9606.ENSP00000445247; -.
DR iPTMnet; A6NJB7; -.
DR PhosphoSitePlus; A6NJB7; -.
DR BioMuta; PRR19; -.
DR EPD; A6NJB7; -.
DR MassIVE; A6NJB7; -.
DR PaxDb; A6NJB7; -.
DR PeptideAtlas; A6NJB7; -.
DR PRIDE; A6NJB7; -.
DR Antibodypedia; 45328; 97 antibodies from 15 providers.
DR DNASU; 284338; -.
DR Ensembl; ENST00000341747.8; ENSP00000342709.3; ENSG00000188368.11. [A6NJB7-1]
DR Ensembl; ENST00000499536.2; ENSP00000445247.1; ENSG00000188368.11. [A6NJB7-1]
DR Ensembl; ENST00000595750.2; ENSP00000469298.2; ENSG00000188368.11. [A6NJB7-1]
DR Ensembl; ENST00000598490.1; ENSP00000472962.1; ENSG00000188368.11. [A6NJB7-2]
DR GeneID; 284338; -.
DR KEGG; hsa:284338; -.
DR MANE-Select; ENST00000341747.8; ENSP00000342709.3; NM_199285.3; NP_954979.2.
DR UCSC; uc002oth.2; human. [A6NJB7-1]
DR CTD; 284338; -.
DR GeneCards; PRR19; -.
DR HGNC; HGNC:33728; PRR19.
DR HPA; ENSG00000188368; Tissue enriched (testis).
DR neXtProt; NX_A6NJB7; -.
DR OpenTargets; ENSG00000188368; -.
DR PharmGKB; PA162400164; -.
DR VEuPathDB; HostDB:ENSG00000188368; -.
DR eggNOG; ENOG502T05H; Eukaryota.
DR GeneTree; ENSGT00390000010703; -.
DR HOGENOM; CLU_073234_0_0_1; -.
DR InParanoid; A6NJB7; -.
DR OMA; PFQRPEK; -.
DR OrthoDB; 1194731at2759; -.
DR PhylomeDB; A6NJB7; -.
DR TreeFam; TF341908; -.
DR PathwayCommons; A6NJB7; -.
DR SignaLink; A6NJB7; -.
DR BioGRID-ORCS; 284338; 18 hits in 1073 CRISPR screens.
DR ChiTaRS; PRR19; human.
DR GenomeRNAi; 284338; -.
DR Pharos; A6NJB7; Tdark.
DR PRO; PR:A6NJB7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NJB7; protein.
DR Bgee; ENSG00000188368; Expressed in left testis and 127 other tissues.
DR ExpressionAtlas; A6NJB7; baseline and differential.
DR Genevisible; A6NJB7; HS.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR029355; Pro-rich_19.
DR PANTHER; PTHR37346; PTHR37346; 1.
DR Pfam; PF15455; Pro-rich_19; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..356
FT /note="Proline-rich protein 19"
FT /id="PRO_0000332273"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 202..356
FT /note="AKPGVSERKMTPFWINSPDQVPEQERQRKQQGTKEFTFPMPYTSSMPTAHRG
FT SLAPPRGPWPPYFPSLSSPSGTAWGPPTAFDLLKSIWLVATPPPPRPWGVGLPQPLPQP
FT SSPLLPRTSVLDWSPSPPSPLPSLSWVVAQSSPEAWSFPPMRLY -> ERPSCPCTPLS
FT FVGSSSASLYASFLCARGQAWGL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033371"
FT CONFLICT 99
FT /note="S -> N (in Ref. 1; BAF84217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 356 AA; 38716 MW; D14B1F45D366FD15 CRC64;
MDTQGPVSQP FQQPEKPGRV RRRKTRRERN KALVGSRRPL AHHDPPVAIR DPPVVPTASK
LVVITQGRLS REHRGLFNHE VKSLDVARLL SSGTLVPGSP TLPAKPSPSP GRAQEPAPRS
RDKENQVPGG SGPGPPSSPE LSGVGQLLAE LQCQLSLPQA FPRRNLIQDA RDAIVHTLQA
CHGCVPDLAL VLRGCQPPLP GAKPGVSERK MTPFWINSPD QVPEQERQRK QQGTKEFTFP
MPYTSSMPTA HRGSLAPPRG PWPPYFPSLS SPSGTAWGPP TAFDLLKSIW LVATPPPPRP
WGVGLPQPLP QPSSPLLPRT SVLDWSPSPP SPLPSLSWVV AQSSPEAWSF PPMRLY
