PRR19_MOUSE
ID PRR19_MOUSE Reviewed; 366 AA.
AC B2RW88;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Proline-rich protein 19 {ECO:0000305};
GN Name=Prr19 {ECO:0000312|MGI:MGI:3648539};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUBCELLULAR LOCATION, FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH
RP CNTD1, AND TISSUE SPECIFICITY.
RX PubMed=32555348; DOI=10.1038/s41467-020-16885-3;
RA Bondarieva A., Raveendran K., Telychko V., Rao H.B.D.P., Ravindranathan R.,
RA Zorzompokou C., Finsterbusch F., Dereli I., Papanikos F., Traenkner D.,
RA Schleiffer A., Fei J.F., Klimova A., Ito M., Kulkarni D.S., Roeder I.,
RA Hunter N., Toth A.;
RT "Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote
RT meiotic crossing over in mouse.";
RL Nat. Commun. 11:3101-3101(2020).
CC -!- FUNCTION: Promotes meiotic crossing over formation through its
CC interaction with CNTD1 by participating in the crossover
CC differentiation step of crossover-specific recombination intermediates.
CC {ECO:0000269|PubMed:32555348}.
CC -!- SUBUNIT: Interacts with CNTD1. {ECO:0000269|PubMed:32555348}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32555348}. Chromosome
CC {ECO:0000269|PubMed:32555348}. Note=Co-localized at crossover sites
CC with CNTD1 (PubMed:32555348). Localizes on synapsed chromosome only in
CC mid/late pachytene spermatocytes (PubMed:32555348).
CC {ECO:0000269|PubMed:32555348}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in gonads.
CC {ECO:0000269|PubMed:32555348}.
CC -!- DISRUPTION PHENOTYPE: Mice are unfertile in both sexes. Testis weight
CC is significantly lower. Mice males show a depletion of late prophase
CC spermatocytes. are depleted of post-meiotic cells and their weight is
CC significantly lower. {ECO:0000269|PubMed:32555348}.
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DR EMBL; BC147639; AAI47640.1; -; mRNA.
DR EMBL; BC147641; AAI47642.1; -; mRNA.
DR EMBL; BC147701; AAI47702.1; -; mRNA.
DR EMBL; BC147708; AAI47709.1; -; mRNA.
DR CCDS; CCDS52147.1; -.
DR RefSeq; NP_001074763.1; NM_001081294.1.
DR RefSeq; XP_006540325.1; XM_006540262.1.
DR RefSeq; XP_017177922.1; XM_017322433.1.
DR AlphaFoldDB; B2RW88; -.
DR SMR; B2RW88; -.
DR STRING; 10090.ENSMUSP00000104047; -.
DR PhosphoSitePlus; B2RW88; -.
DR PaxDb; B2RW88; -.
DR PRIDE; B2RW88; -.
DR ProteomicsDB; 332988; -.
DR Antibodypedia; 45328; 97 antibodies from 15 providers.
DR Ensembl; ENSMUST00000080288; ENSMUSP00000104047; ENSMUSG00000058741.
DR GeneID; 623131; -.
DR KEGG; mmu:623131; -.
DR UCSC; uc009fsh.1; mouse.
DR CTD; 284338; -.
DR MGI; MGI:3648539; Prr19.
DR VEuPathDB; HostDB:ENSMUSG00000058741; -.
DR eggNOG; ENOG502T05H; Eukaryota.
DR GeneTree; ENSGT00390000010703; -.
DR HOGENOM; CLU_073234_0_0_1; -.
DR InParanoid; B2RW88; -.
DR OMA; PFQRPEK; -.
DR OrthoDB; 1194731at2759; -.
DR PhylomeDB; B2RW88; -.
DR TreeFam; TF341908; -.
DR BioGRID-ORCS; 623131; 3 hits in 73 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; B2RW88; protein.
DR Bgee; ENSMUSG00000058741; Expressed in testis and 23 other tissues.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR029355; Pro-rich_19.
DR PANTHER; PTHR37346; PTHR37346; 1.
DR Pfam; PF15455; Pro-rich_19; 1.
PE 1: Evidence at protein level;
KW Chromosome; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..366
FT /note="Proline-rich protein 19"
FT /id="PRO_0000454452"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40149 MW; 35C3857E50EDF879 CRC64;
MDPRGPVPQP FQQLQKPGRI RRRKTRRERN KALVSSHRPL ARQDPPISSR DPCVILQDPV
ASAAPKLVVI TQGRLSREHR GLFNHEVKSL DVARLLNRGA LESHTPQLPT KPSCSPVGVQ
EPDLQSKGKE NKVPGGSGPG PPNSPDLPVL GQLLEELQYQ LIVPQAFPRR NLVQESRDTI
IRTLQGCHGC VPDLALVLRG CQLPLPEAKP RVPERQRMAS SCMEVPEHAP REGKQRTQQA
TKGCDFAIPH TCNSTTPAHR GSQVQPPGHQ LPFLSSASSP SGAAWGPPTA FDMLKSIWLI
ATPPPPPPQP WDVRPPQPLP QPPSPLLPRT SALDWSPNPP APLPSLSWVV TQSSPEAWSF
PPMRLY
