PRR22_HUMAN
ID PRR22_HUMAN Reviewed; 422 AA.
AC Q8IZ63; E9PB31;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Proline-rich protein 22;
GN Name=PRR22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-153.
RC TISSUE=Embryonic stem cell;
RX PubMed=15146197; DOI=10.1038/nbt971;
RA Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y.,
RA Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J.,
RA Stanton L.W.;
RT "Transcriptome characterization elucidates signaling networks that control
RT human ES cell growth and differentiation.";
RL Nat. Biotechnol. 22:707-716(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-128.
RC TISSUE=Stomach;
RX PubMed=16341674; DOI=10.1007/s00335-005-0075-2;
RA Oh J.H., Yang J.O., Hahn Y., Kim M.R., Byun S.S., Jeon Y.J., Kim J.M.,
RA Song K.S., Noh S.M., Kim S., Yoo H.S., Kim Y.S., Kim N.S.;
RT "Transcriptome analysis of human gastric cancer.";
RL Mamm. Genome 16:942-954(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH08985.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=AAH23278.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=EAW69147.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471139; EAW69147.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC008985; AAH08985.1; ALT_SEQ; mRNA.
DR EMBL; BC023278; AAH23278.1; ALT_SEQ; mRNA.
DR EMBL; CN370733; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BQ082540; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45933.1; -.
DR RefSeq; NP_001127788.1; NM_001134316.1.
DR AlphaFoldDB; Q8IZ63; -.
DR BioGRID; 127854; 29.
DR IntAct; Q8IZ63; 4.
DR STRING; 9606.ENSP00000407653; -.
DR PhosphoSitePlus; Q8IZ63; -.
DR BioMuta; PRR22; -.
DR DMDM; 391358151; -.
DR jPOST; Q8IZ63; -.
DR MassIVE; Q8IZ63; -.
DR PaxDb; Q8IZ63; -.
DR PeptideAtlas; Q8IZ63; -.
DR PRIDE; Q8IZ63; -.
DR ProteomicsDB; 71281; -.
DR Antibodypedia; 49704; 50 antibodies from 13 providers.
DR DNASU; 163154; -.
DR Ensembl; ENST00000419421.3; ENSP00000407653.2; ENSG00000212123.4.
DR GeneID; 163154; -.
DR KEGG; hsa:163154; -.
DR MANE-Select; ENST00000419421.3; ENSP00000407653.2; NM_001134316.2; NP_001127788.1.
DR UCSC; uc010xiv.1; human.
DR CTD; 163154; -.
DR GeneCards; PRR22; -.
DR HGNC; HGNC:28354; PRR22.
DR HPA; ENSG00000212123; Tissue enriched (testis).
DR neXtProt; NX_Q8IZ63; -.
DR OpenTargets; ENSG00000212123; -.
DR PharmGKB; PA165394215; -.
DR VEuPathDB; HostDB:ENSG00000212123; -.
DR eggNOG; ENOG502SI56; Eukaryota.
DR GeneTree; ENSGT00390000016128; -.
DR HOGENOM; CLU_053707_0_0_1; -.
DR InParanoid; Q8IZ63; -.
DR OMA; RIEWTTP; -.
DR OrthoDB; 1583493at2759; -.
DR PhylomeDB; Q8IZ63; -.
DR TreeFam; TF350682; -.
DR PathwayCommons; Q8IZ63; -.
DR SignaLink; Q8IZ63; -.
DR BioGRID-ORCS; 163154; 35 hits in 1072 CRISPR screens.
DR GenomeRNAi; 163154; -.
DR Pharos; Q8IZ63; Tdark.
DR PRO; PR:Q8IZ63; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IZ63; protein.
DR Bgee; ENSG00000212123; Expressed in right testis and 90 other tissues.
DR ExpressionAtlas; Q8IZ63; baseline and differential.
DR Genevisible; Q8IZ63; HS.
DR InterPro; IPR031535; PRR22.
DR PANTHER; PTHR37871; PTHR37871; 1.
DR Pfam; PF15776; PRR22; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..422
FT /note="Proline-rich protein 22"
FT /id="PRO_0000332165"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 118
FT /note="P -> L (in dbSNP:rs3745640)"
FT /id="VAR_042962"
FT CONFLICT 120
FT /note="P -> L (in Ref. 4; BQ082540)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 43980 MW; 48169A0A2ABC7F85 CRC64;
MQHPKPFCAP AAPQEGFSPQ SLEGAEVLGN QPAPTCAEPP PAMGSLNLYH PPDPEKEVFP
APPAGFQMAP CGCFFDPRIY RIEWTTPDLG QSALYKLAAS SGGPAGVPSA PGSYLLEPQP
YLKAPGLPPY PHYQQAPGGP QFLLPYFPPE GPGPEALGFV GDAGPAAFVE LPLPPLEEGP
APLPPPPPKE NKPPPVLITL PAEPTLPPDA YSHLQGHLGH FPGPEPLAFP VKELQGSGAR
PGVPLYPPGL SELKVAEVKE GALLGAGKAK APKTARALAL PDKVLLEDAM KLFDCLPGAS
EPEGTLCEVP GPALPDSSGG NSADDIRSLC LPEELLSFDY SVPEILDTVS NVDYFFNFKA
LDEEQPPHPG PPATNTPAPI LSGKRKASTA KKGKPGRKAR QPAGPASATP PGPREDLGAT
PH
