ID   PRR25_HUMAN             Reviewed;         402 AA.
AC   Q96S07;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Proline-rich protein 25;
GN   Name=PRR25; ORFNames=gs64;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA   Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA   Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT   "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT   the short arm of human chromosome 16.";
RL   Hum. Mol. Genet. 10:339-352(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
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DR   EMBL; AE006465; AAK61258.1; -; Genomic_DNA.
DR   EMBL; AL023882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL031033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001013660.1; NM_001013638.1.
DR   AlphaFoldDB; Q96S07; -.
DR   BioGRID; 132599; 16.
DR   STRING; 9606.ENSP00000301698; -.
DR   iPTMnet; Q96S07; -.
DR   PhosphoSitePlus; Q96S07; -.
DR   BioMuta; PRR25; -.
DR   DMDM; 74717263; -.
DR   PaxDb; Q96S07; -.
DR   PeptideAtlas; Q96S07; -.
DR   PRIDE; Q96S07; -.
DR   ProteomicsDB; 78051; -.
DR   DNASU; 388199; -.
DR   GeneID; 388199; -.
DR   KEGG; hsa:388199; -.
DR   UCSC; uc010uut.2; human.
DR   CTD; 388199; -.
DR   GeneCards; PRR25; -.
DR   HGNC; HGNC:37230; PRR25.
DR   neXtProt; NX_Q96S07; -.
DR   PharmGKB; PA165450599; -.
DR   eggNOG; ENOG502TENU; Eukaryota.
DR   HOGENOM; CLU_698216_0_0_1; -.
DR   InParanoid; Q96S07; -.
DR   OrthoDB; 637347at2759; -.
DR   PhylomeDB; Q96S07; -.
DR   TreeFam; TF341855; -.
DR   PathwayCommons; Q96S07; -.
DR   SignaLink; Q96S07; -.
DR   BioGRID-ORCS; 388199; 10 hits in 1056 CRISPR screens.
DR   GenomeRNAi; 388199; -.
DR   Pharos; Q96S07; Tdark.
DR   PRO; PR:Q96S07; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q96S07; protein.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Proline-rich protein 25"
FT                   /id="PRO_0000394497"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..368
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         92
FT                   /note="T -> S (in dbSNP:rs1005190)"
FT                   /id="VAR_063210"
FT   VARIANT         249
FT                   /note="P -> L (in dbSNP:rs13337837)"
FT                   /id="VAR_063211"
SQ   SEQUENCE   402 AA;  40998 MW;  C7CCE92B17024D61 CRC64;
     MARTDQKPPC RGGCWGQPGH PNTGGAAAHP TYHPMGHRPR TCILLRGDQT TGGQAPSREI
     SLGPWAAGTH FLAISTTPWG RKTPACISEL PTSSGTAQPL ANAVCEVQTV PGPGLRPQGT
     PAMRAPSHKG TPPTPNPWGP EQPQNRHKHP KKGVTGGPSP PPPAASRYGQ TPGREPRVQA
     PGLGPCGRPA SGRLLSLHLE KGDGKGTRQR IPLTDAAVGG DRTDIPSAIA AGPARTPDRH
     GLPIPGSTPT PMVGSGRLGA PVGRSGGGAS ARSSRPSCAN VLLRADASLG TVLSVLWTGQ
     LSRGWALLPP GDAGRHLETS VISAGVAAGI WLVEPGEAAQ DPATRRTAPP RRTASPEPPA
     PGAPLPACPG RIPGAARFGP RSCPLGSPAV LAVTTGWSHR SV