PRR27_HUMAN
ID PRR27_HUMAN Reviewed; 219 AA.
AC Q6MZM9; A8MXP0; Q6MZR6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Proline-rich protein 27;
DE Flags: Precursor;
GN Name=PRR27; Synonyms=C4orf40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BX640924; CAE45962.1; -; mRNA.
DR EMBL; BX640997; CAE46000.1; -; mRNA.
DR EMBL; BX640892; CAH56124.1; -; mRNA.
DR EMBL; BX648724; CAH56126.1; -; mRNA.
DR EMBL; AC104811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS3535.1; -.
DR RefSeq; NP_999876.2; NM_214711.3.
DR AlphaFoldDB; Q6MZM9; -.
DR BioGRID; 134945; 17.
DR STRING; 9606.ENSP00000343172; -.
DR BioMuta; PRR27; -.
DR MassIVE; Q6MZM9; -.
DR PaxDb; Q6MZM9; -.
DR PeptideAtlas; Q6MZM9; -.
DR PRIDE; Q6MZM9; -.
DR ProteomicsDB; 66574; -.
DR Antibodypedia; 50084; 31 antibodies from 7 providers.
DR DNASU; 401137; -.
DR Ensembl; ENST00000344526.10; ENSP00000343172.5; ENSG00000187533.14.
DR Ensembl; ENST00000502294.5; ENSP00000426249.1; ENSG00000187533.14.
DR Ensembl; ENST00000634325.2; ENSP00000489399.1; ENSG00000282868.2.
DR Ensembl; ENST00000634530.1; ENSP00000489097.1; ENSG00000282868.2.
DR GeneID; 401137; -.
DR KEGG; hsa:401137; -.
DR MANE-Select; ENST00000344526.10; ENSP00000343172.5; NM_214711.4; NP_999876.2.
DR UCSC; uc003hfa.5; human.
DR CTD; 401137; -.
DR GeneCards; PRR27; -.
DR HGNC; HGNC:33193; PRR27.
DR HPA; ENSG00000187533; Tissue enriched (salivary).
DR neXtProt; NX_Q6MZM9; -.
DR OpenTargets; ENSG00000187533; -.
DR PharmGKB; PA162379834; -.
DR VEuPathDB; HostDB:ENSG00000187533; -.
DR eggNOG; ENOG502SCUZ; Eukaryota.
DR GeneTree; ENSGT00530000064615; -.
DR HOGENOM; CLU_111396_0_0_1; -.
DR InParanoid; Q6MZM9; -.
DR OMA; PPRDFPF; -.
DR OrthoDB; 1495985at2759; -.
DR PhylomeDB; Q6MZM9; -.
DR TreeFam; TF338159; -.
DR PathwayCommons; Q6MZM9; -.
DR BioGRID-ORCS; 401137; 7 hits in 1053 CRISPR screens.
DR ChiTaRS; PRR27; human.
DR GenomeRNAi; 401137; -.
DR Pharos; Q6MZM9; Tdark.
DR PRO; PR:Q6MZM9; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6MZM9; protein.
DR Bgee; ENSG00000187533; Expressed in saliva-secreting gland and 20 other tissues.
DR ExpressionAtlas; Q6MZM9; baseline and differential.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR InterPro; IPR033533; PRR27.
DR PANTHER; PTHR39415; PTHR39415; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..219
FT /note="Proline-rich protein 27"
FT /id="PRO_0000339182"
FT REGION 155..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 44
FT /note="I -> L (in dbSNP:rs1612460)"
FT /id="VAR_043927"
FT VARIANT 91
FT /note="R -> C (in dbSNP:rs1613461)"
FT /id="VAR_043928"
FT CONFLICT 44
FT /note="I -> V (in Ref. 1; CAE45962)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 22720 MW; 33972CAD0D806942 CRC64;
MKLLLWACIV CVAFARKRRF PFIGEDDNDD GHPLHPSLNI PYGIRNLPPP LYYRPVNTVP
SYPGNTYTDT GLPSYPWILT SPGFPYVYHI RGFPLATQLN VPPLPPRGFP FVPPSRFFSA
AAAPAAPPIA AEPAAAAPLT ATPVAAEPAA GAPVAAEPAA EAPVGAEPAA EAPVAAEPAA
EAPVGVEPAA EEPSPAEPAT AKPAAPEPHP SPSLEQANQ
