PRR29_HUMAN
ID PRR29_HUMAN Reviewed; 189 AA.
AC P0C7W0; B3KMP0; B4DZJ9; B4E2F8; E9PGL5; J3QKX4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Proline-rich protein 29;
GN Name=PRR29; Synonyms=C17orf72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), AND
RP VARIANT SER-24.
RC TISSUE=Embryo, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=P0C7W0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0C7W0-2; Sequence=VSP_045346;
CC Name=3;
CC IsoId=P0C7W0-3; Sequence=VSP_045344, VSP_045345;
CC Name=4;
CC IsoId=P0C7W0-4; Sequence=VSP_046997;
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DR EMBL; AK021786; BAG51052.1; -; mRNA.
DR EMBL; AK302960; BAG64111.1; -; mRNA.
DR EMBL; AK304254; BAG65120.1; -; mRNA.
DR EMBL; DB037384; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC005803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54157.1; -. [P0C7W0-2]
DR CCDS; CCDS54158.1; -. [P0C7W0-1]
DR CCDS; CCDS54159.1; -. [P0C7W0-3]
DR CCDS; CCDS58586.1; -. [P0C7W0-4]
DR RefSeq; NP_001157729.1; NM_001164257.1. [P0C7W0-1]
DR RefSeq; NP_001177958.1; NM_001191029.1. [P0C7W0-2]
DR RefSeq; NP_001177959.1; NM_001191030.1. [P0C7W0-4]
DR RefSeq; NP_001177960.1; NM_001191031.1. [P0C7W0-3]
DR AlphaFoldDB; P0C7W0; -.
DR STRING; 9606.ENSP00000396936; -.
DR BioMuta; PRR29; -.
DR MassIVE; P0C7W0; -.
DR PaxDb; P0C7W0; -.
DR PeptideAtlas; P0C7W0; -.
DR PRIDE; P0C7W0; -.
DR ProteomicsDB; 20341; -.
DR ProteomicsDB; 52380; -. [P0C7W0-1]
DR Antibodypedia; 52676; 1 antibodies from 1 providers.
DR DNASU; 92340; -.
DR Ensembl; ENST00000412177.6; ENSP00000400986.1; ENSG00000224383.8. [P0C7W0-1]
DR Ensembl; ENST00000425164.7; ENSP00000396936.3; ENSG00000224383.8. [P0C7W0-2]
DR Ensembl; ENST00000577953.5; ENSP00000463279.1; ENSG00000224383.8. [P0C7W0-3]
DR Ensembl; ENST00000579184.5; ENSP00000462097.1; ENSG00000224383.8. [P0C7W0-4]
DR GeneID; 92340; -.
DR KEGG; hsa:92340; -.
DR MANE-Select; ENST00000412177.6; ENSP00000400986.1; NM_001164257.2; NP_001157729.1.
DR UCSC; uc002jdt.5; human. [P0C7W0-1]
DR CTD; 92340; -.
DR GeneCards; PRR29; -.
DR HGNC; HGNC:25673; PRR29.
DR HPA; ENSG00000224383; Tissue enriched (fallopian).
DR neXtProt; NX_P0C7W0; -.
DR OpenTargets; ENSG00000224383; -.
DR PharmGKB; PA142672220; -.
DR VEuPathDB; HostDB:ENSG00000224383; -.
DR eggNOG; ENOG502S6FU; Eukaryota.
DR GeneTree; ENSGT00390000002000; -.
DR HOGENOM; CLU_2333053_0_0_1; -.
DR InParanoid; P0C7W0; -.
DR OMA; HYLPCPM; -.
DR OrthoDB; 1322603at2759; -.
DR PathwayCommons; P0C7W0; -.
DR BioGRID-ORCS; 92340; 5 hits in 1066 CRISPR screens.
DR ChiTaRS; PRR29; human.
DR GenomeRNAi; 92340; -.
DR Pharos; P0C7W0; Tdark.
DR PRO; PR:P0C7W0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P0C7W0; protein.
DR Bgee; ENSG00000224383; Expressed in right uterine tube and 149 other tissues.
DR ExpressionAtlas; P0C7W0; baseline and differential.
DR Genevisible; P0C7W0; HS.
DR InterPro; IPR027904; DUF4587.
DR InterPro; IPR038915; PRR29-like.
DR PANTHER; PTHR28604; PTHR28604; 1.
DR Pfam; PF15248; DUF4587; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..189
FT /note="Proline-rich protein 29"
FT /id="PRO_0000344468"
FT REGION 152..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 22..28
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046997"
FT VAR_SEQ 82..98
FT /note="VYLEVPQEEPEEEEEEM -> ESCAPTPTPQCHRDCGC (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045344"
FT VAR_SEQ 99..189
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045345"
FT VAR_SEQ 157..189
FT /note="VRAVPPPPPPSATGTVGADVPPASDYYDAESLL -> TTMMPRASYEDRPRP
FT WELHQLPALDTAPEPPPAPLLSTPRCPWLAVLLTPSTSARPSSPGEISPCPTPMSSWTG
FT RICAVV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045346"
FT VARIANT 24
FT /note="T -> S (in dbSNP:rs62070903)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_069055"
FT CONFLICT 145
FT /note="R -> S (in Ref. 1; BAG51052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 20715 MW; 1110D9410668AD7C CRC64;
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL MMLQNAQMHQ
LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV REKGPLVFHH HYLPYLMPSP
GALLPWPAPF FPTPACQPYL QDVPRIQHCP ASREREVRAV PPPPPPSATG TVGADVPPAS
DYYDAESLL
