ID   PRR30_HUMAN             Reviewed;         412 AA.
AC   Q53SZ7; Q86UE2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Proline-rich protein 30;
GN   Name=PRR30; Synonyms=C2orf53;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-194.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q53SZ7; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12360827, EBI-3867333;
CC       Q53SZ7; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-12360827, EBI-11962084;
CC       Q53SZ7; Q96LM6: TEX37; NbExp=3; IntAct=EBI-12360827, EBI-743976;
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DR   EMBL; AC013403; AAX93171.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00625.1; -; Genomic_DNA.
DR   EMBL; BC045671; AAH45671.1; -; mRNA.
DR   CCDS; CCDS1739.1; -.
DR   RefSeq; NP_848648.2; NM_178553.3.
DR   AlphaFoldDB; Q53SZ7; -.
DR   BioGRID; 130932; 25.
DR   IntAct; Q53SZ7; 3.
DR   STRING; 9606.ENSP00000335017; -.
DR   GlyGen; Q53SZ7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q53SZ7; -.
DR   PhosphoSitePlus; Q53SZ7; -.
DR   BioMuta; PRR30; -.
DR   jPOST; Q53SZ7; -.
DR   MassIVE; Q53SZ7; -.
DR   PaxDb; Q53SZ7; -.
DR   PeptideAtlas; Q53SZ7; -.
DR   PRIDE; Q53SZ7; -.
DR   ProteomicsDB; 62541; -.
DR   Antibodypedia; 55555; 56 antibodies from 15 providers.
DR   DNASU; 339779; -.
DR   Ensembl; ENST00000335524.7; ENSP00000335017.3; ENSG00000186143.11.
DR   GeneID; 339779; -.
DR   KEGG; hsa:339779; -.
DR   MANE-Select; ENST00000335524.7; ENSP00000335017.3; NM_178553.4; NP_848648.2.
DR   UCSC; uc002rjb.3; human.
DR   CTD; 339779; -.
DR   GeneCards; PRR30; -.
DR   HGNC; HGNC:28677; PRR30.
DR   HPA; ENSG00000186143; Tissue enriched (testis).
DR   neXtProt; NX_Q53SZ7; -.
DR   OpenTargets; ENSG00000186143; -.
DR   PharmGKB; PA162379215; -.
DR   VEuPathDB; HostDB:ENSG00000186143; -.
DR   eggNOG; ENOG502SSVJ; Eukaryota.
DR   GeneTree; ENSGT00390000005754; -.
DR   HOGENOM; CLU_056385_0_0_1; -.
DR   InParanoid; Q53SZ7; -.
DR   OMA; HRRIAHD; -.
DR   OrthoDB; 990675at2759; -.
DR   PhylomeDB; Q53SZ7; -.
DR   TreeFam; TF338772; -.
DR   PathwayCommons; Q53SZ7; -.
DR   SignaLink; Q53SZ7; -.
DR   BioGRID-ORCS; 339779; 17 hits in 1046 CRISPR screens.
DR   GenomeRNAi; 339779; -.
DR   Pharos; Q53SZ7; Tdark.
DR   PRO; PR:Q53SZ7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q53SZ7; protein.
DR   Bgee; ENSG00000186143; Expressed in left testis and 42 other tissues.
DR   ExpressionAtlas; Q53SZ7; baseline and differential.
DR   Genevisible; Q53SZ7; HS.
DR   InterPro; IPR031461; DUF4679.
DR   PANTHER; PTHR22235; PTHR22235; 1.
DR   Pfam; PF15728; DUF4679; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..412
FT                   /note="Proline-rich protein 30"
FT                   /id="PRO_0000312276"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         194
FT                   /note="R -> G (in dbSNP:rs17855664)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037469"
FT   VARIANT         222
FT                   /note="R -> C (in dbSNP:rs3739097)"
FT                   /id="VAR_037470"
SQ   SEQUENCE   412 AA;  44690 MW;  FFCB65B95D5461B6 CRC64;
     MLPQNKDQVL PQTSVLPGRP TWGFSQLVDS SPHNLQPLSP HQGLPPSQPP FSSTQSRRPS
     SPPPASPSPG FQFGSCDSNS DFAPHPYSPS LPSSPTFFHQ NYLSLPRPRA SSPSNHWLYP
     SPPLTPSFSP SQPQNSSLPH SPCQSPSHPE ELHSSTLTSP GPSPPSHRLH SNRQTWRWHQ
     YRDTGSGSPG VVERCVPSEK DPAQFRDPGA LAQALVVQLG HRRIAHDLRL LLLQHLWLGR
     TGQAPVVEYP ICLVCLRPRS PSCPLPRYRT GPRLLAFPQL LPCVQGQESG PLRIGIGFGL
     RLPQGQARAL HLLPEKRPKE AGPQGKATQA CGHQLPASQP PAAQARADPV PGTPSQTRSF
     RSAGLQSPNS PRCFSGPPPR APKQVTTSLK PRPCPGPKRP VSLELILQKS SV