PRR34_HUMAN
ID PRR34_HUMAN Reviewed; 138 AA.
AC Q9NV39; B0QZ24;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Proline-rich protein 34;
GN Name=PRR34; Synonyms=C22orf26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovarian carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q9NV39; O95817: BAG3; NbExp=3; IntAct=EBI-11959565, EBI-747185;
CC Q9NV39; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-11959565, EBI-11524452;
CC Q9NV39; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-11959565, EBI-11983447;
CC Q9NV39; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11959565, EBI-3867333;
CC Q9NV39; Q15038: DAZAP2; NbExp=3; IntAct=EBI-11959565, EBI-724310;
CC Q9NV39; Q86UW9: DTX2; NbExp=3; IntAct=EBI-11959565, EBI-740376;
CC Q9NV39; P52597: HNRNPF; NbExp=3; IntAct=EBI-11959565, EBI-352986;
CC Q9NV39; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-11959565, EBI-8638439;
CC Q9NV39; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-11959565, EBI-751260;
CC Q9NV39; Q99750: MDFI; NbExp=3; IntAct=EBI-11959565, EBI-724076;
CC Q9NV39; P86480: PRR20D; NbExp=6; IntAct=EBI-11959565, EBI-12754095;
CC Q9NV39; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-11959565, EBI-372094;
CC Q9NV39; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-11959565, EBI-742740;
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DR EMBL; AK001807; BAA91920.1; -; mRNA.
DR EMBL; AL121672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73396.1; -; Genomic_DNA.
DR RefSeq; NP_060750.1; NM_018280.2.
DR AlphaFoldDB; Q9NV39; -.
DR BioGRID; 120556; 22.
DR IntAct; Q9NV39; 13.
DR STRING; 9606.ENSP00000379329; -.
DR BioMuta; PRR34; -.
DR PaxDb; Q9NV39; -.
DR PRIDE; Q9NV39; -.
DR DNASU; 55267; -.
DR UCSC; uc003bgq.2; human.
DR GeneCards; PRR34; -.
DR HGNC; HGNC:25606; PRR34.
DR neXtProt; NX_Q9NV39; -.
DR PharmGKB; PA145149369; -.
DR eggNOG; ENOG502TDME; Eukaryota.
DR HOGENOM; CLU_1975572_0_0_1; -.
DR InParanoid; Q9NV39; -.
DR OrthoDB; 1584340at2759; -.
DR PhylomeDB; Q9NV39; -.
DR TreeFam; TF341481; -.
DR PathwayCommons; Q9NV39; -.
DR SignaLink; Q9NV39; -.
DR BioGRID-ORCS; 55267; 10 hits in 1065 CRISPR screens.
DR GenomeRNAi; 55267; -.
DR Pharos; Q9NV39; Tdark.
DR PRO; PR:Q9NV39; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9NV39; protein.
DR Genevisible; Q9NV39; HS.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..138
FT /note="Proline-rich protein 34"
FT /id="PRO_0000271108"
FT REGION 22..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 28
FT /note="P -> L (in dbSNP:rs12159707)"
FT /id="VAR_061635"
FT VARIANT 137
FT /note="Q -> R (in dbSNP:rs59929908)"
FT /id="VAR_061636"
SQ SEQUENCE 138 AA; 14718 MW; B1737A3C8DCFDDCD CRC64;
MPASATAAWH CPPLCLPPLP ASAPTSPPNP ATRPAPGPGR RARCPQSAHP APTRGALTFW
APGSWPRVLL VPRSPGPVLR APRLPHPAAR ARRRAWHGAR LPGSPARAGR TFQRGLVSNS
WAHAIFLPRP PNVLELQV
