PRR35_HUMAN
ID PRR35_HUMAN Reviewed; 571 AA.
AC P0CG20; B8ZZ27; Q8N233; Q96AX3; Q96S23;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Proline-rich protein 35;
DE AltName: Full=Uncharacterized protein RJD1;
GN Name=PRR35; Synonyms=C16orf11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0CG20; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-11986293, EBI-12318443;
CC P0CG20; Q03154: ACY1; NbExp=3; IntAct=EBI-11986293, EBI-742064;
CC P0CG20; Q8NEU8: APPL2; NbExp=3; IntAct=EBI-11986293, EBI-741261;
CC P0CG20; Q96C12: ARMC5; NbExp=3; IntAct=EBI-11986293, EBI-6425121;
CC P0CG20; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-11986293, EBI-12809012;
CC P0CG20; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-11986293, EBI-742722;
CC P0CG20; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-11986293, EBI-517623;
CC P0CG20; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-11986293, EBI-953896;
CC P0CG20; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-11986293, EBI-718615;
CC P0CG20; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-11986293, EBI-11976299;
CC P0CG20; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11986293, EBI-3866279;
CC P0CG20; Q9NZN8: CNOT2; NbExp=3; IntAct=EBI-11986293, EBI-743033;
CC P0CG20; O43186: CRX; NbExp=3; IntAct=EBI-11986293, EBI-748171;
CC P0CG20; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11986293, EBI-3867333;
CC P0CG20; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-11986293, EBI-742102;
CC P0CG20; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-11986293, EBI-12193763;
CC P0CG20; Q13643: FHL3; NbExp=3; IntAct=EBI-11986293, EBI-741101;
CC P0CG20; O94915-2: FRYL; NbExp=3; IntAct=EBI-11986293, EBI-12023420;
CC P0CG20; O75420: GIGYF1; NbExp=3; IntAct=EBI-11986293, EBI-947774;
CC P0CG20; O75791: GRAP2; NbExp=3; IntAct=EBI-11986293, EBI-740418;
CC P0CG20; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-11986293, EBI-748420;
CC P0CG20; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-11986293, EBI-10961706;
CC P0CG20; P84074: HPCA; NbExp=3; IntAct=EBI-11986293, EBI-12197079;
CC P0CG20; Q16082: HSPB2; NbExp=3; IntAct=EBI-11986293, EBI-739395;
CC P0CG20; Q1MX18: INSC; NbExp=3; IntAct=EBI-11986293, EBI-12081118;
CC P0CG20; Q5TA45: INTS11; NbExp=3; IntAct=EBI-11986293, EBI-748258;
CC P0CG20; P14923: JUP; NbExp=3; IntAct=EBI-11986293, EBI-702484;
CC P0CG20; Q53HC5: KLHL26; NbExp=3; IntAct=EBI-11986293, EBI-724915;
CC P0CG20; Q15323: KRT31; NbExp=3; IntAct=EBI-11986293, EBI-948001;
CC P0CG20; O76011: KRT34; NbExp=5; IntAct=EBI-11986293, EBI-1047093;
CC P0CG20; Q92764: KRT35; NbExp=3; IntAct=EBI-11986293, EBI-1058674;
CC P0CG20; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11986293, EBI-10172290;
CC P0CG20; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11986293, EBI-10210845;
CC P0CG20; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11986293, EBI-3957672;
CC P0CG20; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-11986293, EBI-12111050;
CC P0CG20; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-11986293, EBI-11962084;
CC P0CG20; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-11986293, EBI-10261141;
CC P0CG20; Q14847-2: LASP1; NbExp=3; IntAct=EBI-11986293, EBI-9088686;
CC P0CG20; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-11986293, EBI-2341787;
CC P0CG20; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11986293, EBI-741037;
CC P0CG20; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-11986293, EBI-716006;
CC P0CG20; P59942: MCCD1; NbExp=3; IntAct=EBI-11986293, EBI-11987923;
CC P0CG20; Q13064: MKRN3; NbExp=3; IntAct=EBI-11986293, EBI-2340269;
CC P0CG20; Q4VC12: MSS51; NbExp=3; IntAct=EBI-11986293, EBI-11599933;
CC P0CG20; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11986293, EBI-11522433;
CC P0CG20; O15049: N4BP3; NbExp=3; IntAct=EBI-11986293, EBI-2512055;
CC P0CG20; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11986293, EBI-22310682;
CC P0CG20; O43482: OIP5; NbExp=3; IntAct=EBI-11986293, EBI-536879;
CC P0CG20; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11986293, EBI-12813389;
CC P0CG20; Q99471: PFDN5; NbExp=3; IntAct=EBI-11986293, EBI-357275;
CC P0CG20; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-11986293, EBI-2876622;
CC P0CG20; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-11986293, EBI-2557649;
CC P0CG20; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-11986293, EBI-1105153;
CC P0CG20; P86480: PRR20D; NbExp=3; IntAct=EBI-11986293, EBI-12754095;
CC P0CG20; O43586: PSTPIP1; NbExp=3; IntAct=EBI-11986293, EBI-1050964;
CC P0CG20; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-11986293, EBI-740343;
CC P0CG20; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11986293, EBI-6257312;
CC P0CG20; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-11986293, EBI-12275818;
CC P0CG20; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-11986293, EBI-11959123;
CC P0CG20; O60806: TBX19; NbExp=3; IntAct=EBI-11986293, EBI-12096770;
CC P0CG20; Q08117-2: TLE5; NbExp=5; IntAct=EBI-11986293, EBI-11741437;
CC P0CG20; P14373: TRIM27; NbExp=3; IntAct=EBI-11986293, EBI-719493;
CC P0CG20; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-11986293, EBI-2130429;
CC P0CG20; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-11986293, EBI-10259086;
CC P0CG20; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-11986293, EBI-948354;
CC P0CG20; Q14166: TTLL12; NbExp=3; IntAct=EBI-11986293, EBI-923010;
CC P0CG20; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-11986293, EBI-1380492;
CC P0CG20; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-11986293, EBI-11524408;
CC P0CG20; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11986293, EBI-11975223;
CC P0CG20; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11986293, EBI-12030590;
CC P0CG20; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11986293, EBI-625509;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE006464; AAK61234.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z97986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85802.1; -; Genomic_DNA.
DR EMBL; BC016613; AAH16613.1; -; mRNA.
DR CCDS; CCDS45365.1; -.
DR RefSeq; NP_660313.1; NM_145270.2.
DR RefSeq; XP_016878448.1; XM_017022959.1.
DR RefSeq; XP_016878449.1; XM_017022960.1.
DR AlphaFoldDB; P0CG20; -.
DR SMR; P0CG20; -.
DR BioGRID; 126978; 82.
DR IntAct; P0CG20; 71.
DR STRING; 9606.ENSP00000386499; -.
DR iPTMnet; P0CG20; -.
DR PhosphoSitePlus; P0CG20; -.
DR BioMuta; PRR35; -.
DR DMDM; 298351619; -.
DR jPOST; P0CG20; -.
DR MassIVE; P0CG20; -.
DR PaxDb; P0CG20; -.
DR PeptideAtlas; P0CG20; -.
DR PRIDE; P0CG20; -.
DR Antibodypedia; 68294; 5 antibodies from 5 providers.
DR DNASU; 146325; -.
DR Ensembl; ENST00000409413.4; ENSP00000386499.3; ENSG00000161992.6.
DR GeneID; 146325; -.
DR KEGG; hsa:146325; -.
DR MANE-Select; ENST00000409413.4; ENSP00000386499.3; NM_145270.3; NP_660313.1.
DR UCSC; uc002chk.4; human.
DR CTD; 146325; -.
DR DisGeNET; 146325; -.
DR GeneCards; PRR35; -.
DR HGNC; HGNC:14139; PRR35.
DR HPA; ENSG00000161992; Tissue enriched (brain).
DR neXtProt; NX_P0CG20; -.
DR OpenTargets; ENSG00000161992; -.
DR PharmGKB; PA25524; -.
DR VEuPathDB; HostDB:ENSG00000161992; -.
DR eggNOG; ENOG502QRT7; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_022992_0_0_1; -.
DR InParanoid; P0CG20; -.
DR OMA; SSHTTKC; -.
DR OrthoDB; 485654at2759; -.
DR PhylomeDB; P0CG20; -.
DR TreeFam; TF331381; -.
DR PathwayCommons; P0CG20; -.
DR SignaLink; P0CG20; -.
DR BioGRID-ORCS; 146325; 10 hits in 1049 CRISPR screens.
DR GenomeRNAi; 146325; -.
DR Pharos; P0CG20; Tdark.
DR PRO; PR:P0CG20; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P0CG20; protein.
DR Bgee; ENSG00000161992; Expressed in cerebellar hemisphere and 34 other tissues.
DR Genevisible; P0CG20; HS.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PTHR14678; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..571
FT /note="Proline-rich protein 35"
FT /id="PRO_0000326184"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 59354 MW; 7F15F84F05FF460E CRC64;
MSREAGSCRV GTGARARSRK PKKPHYIPRP WGKPYNYKCF QCPFTCLEKS HLYNHMKYSL
CKDSLSLLLD SPDWACRRGS TTPRPHAPTP DRPGESDPGR QPQGARPTGA APAPDLVVAD
IHSLHCGGGP KSRAKGSPGP PPPVARATRK GPGPSGLLPE SWKPGMGGDP RGVGAGDMAS
AGPEGSVPCY PPPAPGEFPE AHSLHLSLLG VNYPLSPGLF SYLGPSLAAA AHVPFLASAS
PLLPPATAFP AVQPPQRPTP APRLYYPLLL EHTLGLPAGK AALAKAPVSP RSPSGTPAPG
LLKVPVPGLG PWPRVTPRDP GQEGELERAA QSDPRRRLSL GSRLELPKAS PSLTRFCSRS
SLPTGSSVML WPEDGDPGGP ETPGPEGPLP LQPRGPVPGS PEHVGEDLTR ALGDYARVEQ
RLGQLGPAGG LAPRPLREQL GKIRLELLTI HQALEQAVRP PDAPLDLSVK RAPAKGPQAL
GEAWGRPELG PVLTGGTPEP PGMLGPAAPQ PFSGHTTKCE ADSSVPPPGL PLAAPDDPVI
PGSGWGTCVA TRSSQTPEAV CGLQSPQGAE V
