PRR36_HUMAN
ID PRR36_HUMAN Reviewed; 1346 AA.
AC Q9H6K5; A0A087WZ52; Q9H3X1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Proline-rich protein 36 {ECO:0000312|HGNC:HGNC:26172};
GN Name=PRR36 {ECO:0000312|HGNC:HGNC:26172};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 679-1346 (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1109-1346 (ISOFORMS 1/2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H6K5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6K5-2; Sequence=VSP_057467;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC010336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK025837; BAB15254.1; ALT_INIT; mRNA.
DR EMBL; AL442075; CAC09441.1; -; mRNA.
DR CCDS; CCDS74276.1; -. [Q9H6K5-1]
DR RefSeq; NP_001177396.1; NM_001190467.1. [Q9H6K5-1]
DR AlphaFoldDB; Q9H6K5; -.
DR IntAct; Q9H6K5; 6.
DR MINT; Q9H6K5; -.
DR STRING; 9606.ENSP00000482374; -.
DR iPTMnet; Q9H6K5; -.
DR PhosphoSitePlus; Q9H6K5; -.
DR BioMuta; PRR36; -.
DR DMDM; 74718524; -.
DR EPD; Q9H6K5; -.
DR jPOST; Q9H6K5; -.
DR MassIVE; Q9H6K5; -.
DR MaxQB; Q9H6K5; -.
DR PaxDb; Q9H6K5; -.
DR PeptideAtlas; Q9H6K5; -.
DR PRIDE; Q9H6K5; -.
DR Antibodypedia; 70670; 3 antibodies from 3 providers.
DR Ensembl; ENST00000618550.5; ENSP00000482374.1; ENSG00000183248.12. [Q9H6K5-1]
DR GeneID; 80164; -.
DR KEGG; hsa:80164; -.
DR MANE-Select; ENST00000618550.5; ENSP00000482374.1; NM_001190467.2; NP_001177396.1.
DR UCSC; uc032hlq.2; human.
DR CTD; 80164; -.
DR GeneCards; PRR36; -.
DR HGNC; HGNC:26172; PRR36.
DR HPA; ENSG00000183248; Group enriched (brain, pituitary gland).
DR neXtProt; NX_Q9H6K5; -.
DR OpenTargets; ENSG00000183248; -.
DR VEuPathDB; HostDB:ENSG00000183248; -.
DR eggNOG; ENOG502S4AG; Eukaryota.
DR GeneTree; ENSGT00940000154382; -.
DR HOGENOM; CLU_286361_0_0_1; -.
DR OMA; MTTPPMQ; -.
DR OrthoDB; 675357at2759; -.
DR PathwayCommons; Q9H6K5; -.
DR SignaLink; Q9H6K5; -.
DR BioGRID-ORCS; 80164; 2 hits in 122 CRISPR screens.
DR ChiTaRS; PRR36; human.
DR GenomeRNAi; 80164; -.
DR Pharos; Q9H6K5; Tdark.
DR PRO; PR:Q9H6K5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H6K5; protein.
DR Bgee; ENSG00000183248; Expressed in cortical plate and 92 other tissues.
DR ExpressionAtlas; Q9H6K5; baseline and differential.
DR Genevisible; Q9H6K5; HS.
DR InterPro; IPR027907; DUF4596.
DR Pfam; PF15363; DUF4596; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..1346
FT /note="Proline-rich protein 36"
FT /id="PRO_0000329437"
FT REGION 1..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..508
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..586
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..662
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..750
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..772
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..870
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..1032
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1087
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1111
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1310
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:21406692"
FT VAR_SEQ 729..751
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_057467"
FT CONFLICT 1170
FT /note="L -> P (in Ref. 2; BAB15254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1346 AA; 132748 MW; 3021FAACA0F80262 CRC64;
MDNKRDKAKA GAAARTPAAR APGLLTPRPP GSPRPPPPVT PAALRVLGAA GAVGRKPLAE
RAGGIGGATI PESAPRAGPT RSAGTSSRNP ASRPPASGRG ERAPPAKNTS PGPVSSPGRA
SGTTRPGPLG QKGLRISAEE TVARGKATEA PKRSALSAGA RRDTSGPTPG TPSPAMARRS
RAAGTEVGLP RPAPSARPRP PTEGPRKSVS SASEHSTTEP SPAARRRPSA GGGLQRPASR
SLSSSATPLS SPARSGPSAR GTPRAPAHPS QPKPKGLQAL RPPQVTPPRK DAAPALGPLS
SSPLATPSPS GTKARPVPPP DNAATPLPAT LPPSPPVTPP PPAALQSQAP PTLPATPHSS
SLTCQLATPL PLAPPSPSAP PSLQTLPSPP ATPPSQVPPT QLIMSFPEAG VSSLATAAFV
ASVSPSVSSP LQSMPPTQAN PALPSLPTLL SPLATPPLSA MSPLQGPVSP ATSLGNSAFP
LAALPQPGLS ALTTPPPQAS PSPSPPSLQA TPHTLATLPL QDSPLLATLP LQASPSPLTT
VSLQDPPLVS PSLLASPPLQ APPHPQAPPS MTTPPMQAPP SLQTIPPIQV PHSLTSPSLQ
APPSPLALSS LQATTSLGSP TLQATHSFLT MSPRQTQASL ISPSRPASTP PDSPPLQAPL
SLPASPPLQT SLSPAVSPLS SPLTIHPLQA LSSLASHSPQ APLSSLIMPP LETQSSLAPP
SLQTPPASLT TPPLENLPSL APPPLQTASA PLTTPPLENL PSLAPPPLQT ASAPLTTPHL
ETPPCPAPCP LQAPPSPLTT PPPETPSSIA TPPPQAPPAL ASPPLQGLPS PPLSPLATPP
PQAPPALALP PLQAPPSPPA SPPLSPLATP SPQAPNALAV HLLQAPFSPP PSPPVQAPFS
PPASPPVSPS ATPPSQAPPS LAAPPLQVPP SPPASPPMSP SATPPPQAPP PLAAPPLQVP
PSPPASPPMS PSATPPPRVP PLLAAPPLQV PPSPPASLPM SPLAKPPPQA PPALATPPLQ
ALPSPPASFP GQAPFSPSAS LPMSPLATPP PQAPPVLAAP LLQVPPSPPA SPTLQAPRRP
PTPGPDTSVS GPRLTLALAP GPPPPPSRSP SSTLSGPDLA GHSSSATSTP EELRGYDSGP
EGGAAASPPP DAELAACHPA AWSRGPAPPL AFRGAPGAPL PWPPATGPGS ADGLCTIYET
EGPESATPAP GALDPGPSPG TSGGKAAAGA GAGASSRSPK QARLGELPLG ALQASVVQHL
LSRTLLLAAA EGAAGGSGGG PGGAEGGGVT GGARAALSDA ELGRWAELLS PLDESRASIT
SVTSFSPDDV ASPQGDWTVV EVETFH
