PRR3_HUMAN
ID PRR3_HUMAN Reviewed; 188 AA.
AC P79522; A1A4H4; Q5RJB5; Q5STN6;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Proline-rich protein 3;
DE AltName: Full=MHC class I region proline-rich protein CAT56;
GN Name=PRR3; Synonyms=CAT56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wei H., Weissman S.M.;
RT "Human proline rich sequence (CAT 56) from the MHC class I region.";
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-61.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P79522; Q9NRW3: APOBEC3C; NbExp=3; IntAct=EBI-2803328, EBI-1044593;
CC P79522; Q9Y294: ASF1A; NbExp=6; IntAct=EBI-2803328, EBI-749553;
CC P79522; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-2803328, EBI-2808286;
CC P79522; Q92989: CLP1; NbExp=3; IntAct=EBI-2803328, EBI-2559831;
CC P79522; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-2803328, EBI-10226858;
CC P79522; P61978: HNRNPK; NbExp=7; IntAct=EBI-2803328, EBI-304185;
CC P79522; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-2803328, EBI-7060731;
CC P79522; P54652: HSPA2; NbExp=3; IntAct=EBI-2803328, EBI-356991;
CC P79522; Q5VWX1: KHDRBS2; NbExp=6; IntAct=EBI-2803328, EBI-742808;
CC P79522; O75525: KHDRBS3; NbExp=3; IntAct=EBI-2803328, EBI-722504;
CC P79522; Q13351: KLF1; NbExp=3; IntAct=EBI-2803328, EBI-8284732;
CC P79522; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-2803328, EBI-11962084;
CC P79522; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-2803328, EBI-2858213;
CC P79522; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-2803328, EBI-398874;
CC P79522; P25788: PSMA3; NbExp=3; IntAct=EBI-2803328, EBI-348380;
CC P79522; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-2803328, EBI-744023;
CC P79522; P98179: RBM3; NbExp=3; IntAct=EBI-2803328, EBI-2949699;
CC P79522; P38159: RBMX; NbExp=6; IntAct=EBI-2803328, EBI-743526;
CC P79522; P0DJD3: RBMY1A1; NbExp=3; IntAct=EBI-2803328, EBI-8638511;
CC P79522; P0DJD3-2: RBMY1A1; NbExp=3; IntAct=EBI-2803328, EBI-11994018;
CC P79522; Q15415: RBMY1J; NbExp=7; IntAct=EBI-2803328, EBI-8642021;
CC P79522; P49591: SARS1; NbExp=3; IntAct=EBI-2803328, EBI-1053431;
CC P79522; Q08117: TLE5; NbExp=3; IntAct=EBI-2803328, EBI-717810;
CC P79522; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2803328, EBI-11741437;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P79522-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P79522-2; Sequence=VSP_012818;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB40147.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U63336; AAB40147.1; ALT_INIT; mRNA.
DR EMBL; AL662825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX000357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR847863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126457; AAI26458.1; -; mRNA.
DR CCDS; CCDS43440.1; -. [P79522-1]
DR CCDS; CCDS43441.1; -. [P79522-2]
DR RefSeq; NP_079539.2; NM_025263.3. [P79522-1]
DR AlphaFoldDB; P79522; -.
DR BioGRID; 123286; 258.
DR IntAct; P79522; 40.
DR STRING; 9606.ENSP00000365744; -.
DR iPTMnet; P79522; -.
DR MetOSite; P79522; -.
DR PhosphoSitePlus; P79522; -.
DR BioMuta; PRR3; -.
DR DMDM; 59798092; -.
DR EPD; P79522; -.
DR jPOST; P79522; -.
DR MassIVE; P79522; -.
DR MaxQB; P79522; -.
DR PaxDb; P79522; -.
DR PeptideAtlas; P79522; -.
DR PRIDE; P79522; -.
DR ProteomicsDB; 57662; -. [P79522-1]
DR ProteomicsDB; 57663; -. [P79522-2]
DR Antibodypedia; 67374; 34 antibodies from 9 providers.
DR DNASU; 80742; -.
DR Ensembl; ENST00000376557.3; ENSP00000365740.3; ENSG00000204576.12. [P79522-2]
DR Ensembl; ENST00000376560.8; ENSP00000365744.4; ENSG00000204576.12. [P79522-1]
DR Ensembl; ENST00000383592.8; ENSP00000373086.4; ENSG00000206491.12. [P79522-1]
DR Ensembl; ENST00000418065.2; ENSP00000404669.2; ENSG00000206491.12. [P79522-2]
DR Ensembl; ENST00000422140.2; ENSP00000411802.2; ENSG00000228186.10. [P79522-2]
DR Ensembl; ENST00000422639.2; ENSP00000401499.2; ENSG00000229202.10. [P79522-2]
DR Ensembl; ENST00000427729.6; ENSP00000402596.2; ENSG00000223766.10. [P79522-1]
DR Ensembl; ENST00000432371.6; ENSP00000396416.2; ENSG00000228186.10. [P79522-1]
DR Ensembl; ENST00000436805.2; ENSP00000406321.2; ENSG00000233564.10. [P79522-2]
DR Ensembl; ENST00000442290.2; ENSP00000401612.2; ENSG00000223887.10. [P79522-2]
DR Ensembl; ENST00000444972.2; ENSP00000393410.2; ENSG00000223766.10. [P79522-2]
DR Ensembl; ENST00000449754.6; ENSP00000398352.2; ENSG00000233564.10. [P79522-1]
DR Ensembl; ENST00000453232.6; ENSP00000415432.2; ENSG00000229202.10. [P79522-1]
DR Ensembl; ENST00000454399.6; ENSP00000392826.2; ENSG00000223887.10. [P79522-1]
DR GeneID; 80742; -.
DR KEGG; hsa:80742; -.
DR MANE-Select; ENST00000376560.8; ENSP00000365744.4; NM_025263.4; NP_079539.2.
DR UCSC; uc003nqj.3; human. [P79522-1]
DR CTD; 80742; -.
DR DisGeNET; 80742; -.
DR GeneCards; PRR3; -.
DR HGNC; HGNC:21149; PRR3.
DR HPA; ENSG00000204576; Low tissue specificity.
DR neXtProt; NX_P79522; -.
DR OpenTargets; ENSG00000204576; -.
DR PharmGKB; PA134950097; -.
DR VEuPathDB; HostDB:ENSG00000204576; -.
DR eggNOG; ENOG502TAPB; Eukaryota.
DR GeneTree; ENSGT00940000161804; -.
DR HOGENOM; CLU_112270_0_0_1; -.
DR InParanoid; P79522; -.
DR OMA; ESPIGPP; -.
DR PhylomeDB; P79522; -.
DR TreeFam; TF337284; -.
DR PathwayCommons; P79522; -.
DR SignaLink; P79522; -.
DR BioGRID-ORCS; 80742; 21 hits in 1075 CRISPR screens.
DR ChiTaRS; PRR3; human.
DR GenomeRNAi; 80742; -.
DR Pharos; P79522; Tdark.
DR PRO; PR:P79522; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P79522; protein.
DR Bgee; ENSG00000204576; Expressed in cortical plate and 96 other tissues.
DR ExpressionAtlas; P79522; baseline and differential.
DR Genevisible; P79522; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR042805; PRR3.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR47398; PTHR47398; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..188
FT /note="Proline-rich protein 3"
FT /id="PRO_0000213889"
FT ZN_FING 155..183
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 36..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_012818"
FT VARIANT 61
FT /note="G -> S (in dbSNP:rs3888778)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052963"
SQ SEQUENCE 188 AA; 20640 MW; 1EFDAFB4FFBBE153 CRC64;
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK PGDPKSALHR
GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG WWGVNAEPPF PGPGHGGPTR
GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH
PGVNGPPL
