ID   PRRA_MYCLE              Reviewed;         233 AA.
AC   Q50136;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Transcriptional regulatory protein PrrA;
GN   Name=prrA; OrderedLocusNames=ML2123; ORFNames=MLCB57.61c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59.
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system PrrB/PrrA that
CC       is involved specifically in early intracellular multiplication of
CC       Mycobacterium and is essential for its viability. Upon phosphorylation
CC       by PrrB, functions as a transcription regulator by direct binding to
CC       promoter regions of target genes to positively regulate their
CC       expression. Autoregulates its own expression.
CC       {ECO:0000250|UniProtKB:P9WGM1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PrrB at Asp-58. {ECO:0000250|UniProtKB:P9WGM1}.
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DR   EMBL; Z99494; CAB16701.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31078.1; -; Genomic_DNA.
DR   EMBL; U15184; AAA63079.1; -; Genomic_DNA.
DR   PIR; T45359; T45359.
DR   RefSeq; NP_302402.1; NC_002677.1.
DR   RefSeq; WP_010908722.1; NC_002677.1.
DR   AlphaFoldDB; Q50136; -.
DR   SMR; Q50136; -.
DR   STRING; 272631.ML2123; -.
DR   EnsemblBacteria; CAC31078; CAC31078; CAC31078.
DR   KEGG; mle:ML2123; -.
DR   PATRIC; fig|272631.5.peg.4009; -.
DR   Leproma; ML2123; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_11; -.
DR   OMA; KYLMSHP; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..233
FT                   /note="Transcriptional regulatory protein PrrA"
FT                   /id="PRO_0000081326"
FT   DOMAIN          9..123
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        134..232
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         58
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   233 AA;  25110 MW;  A04D774E8537B6F1 CRC64;
     MDTGVSSPRV LVVDDDSDVL ASLERGLRLS GFEVSTAIDG AEALRNATET RPDAIVLDIN
     MPVLDGVSVV TALRAMDNDV PVCVLSARSS VDDRVAGLEA GADDYLVKPF VLAELVARVK
     ALLRRRGATA TSSSETIAVG PLEVDIPGRR ARVNGVDVDL TKREFDLLAV LAEHKTTVLS
     RAQLLELVWG YDFAADTNVV DVFIGYLRRK LEANSGPRLL HTVRGVGFVL RMQ