PRRC1_HUMAN
ID PRRC1_HUMAN Reviewed; 445 AA.
AC Q96M27; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein PRRC1;
DE AltName: Full=Proline-rich and coiled-coil-containing protein 1;
GN Name=PRRC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), SUBCELLULAR LOCATION,
RP AND TISSUE SPECIFICITY.
RC TISSUE=Heart, Liver, and Peripheral blood;
RX PubMed=15541471; DOI=10.1016/j.leukres.2004.04.019;
RA Kamakari S., Roussou A., Jefferson A., Ragoussis I., Anagnou N.P.;
RT "Structural analysis and expression profile of a novel gene on chromosome
RT 5q23 encoding a Golgi-associated protein with six splice variants, and
RT involved within the 5q deletion of a Ph(-) CML patient.";
RL Leuk. Res. 29:17-31(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
RC TISSUE=Skeletal muscle, and Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-408, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q96M27; P42858: HTT; NbExp=7; IntAct=EBI-2560879, EBI-466029;
CC Q96M27; Q13526: PIN1; NbExp=3; IntAct=EBI-2560879, EBI-714158;
CC Q96M27; Q15437: SEC23B; NbExp=3; IntAct=EBI-2560879, EBI-742673;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15541471}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q96M27-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96M27-2; Sequence=VSP_028724;
CC Name=3;
CC IsoId=Q96M27-3; Sequence=VSP_028725;
CC Name=4;
CC IsoId=Q96M27-4; Sequence=VSP_028720, VSP_028721;
CC Name=5;
CC IsoId=Q96M27-5; Sequence=VSP_028722, VSP_028723;
CC -!- TISSUE SPECIFICITY: Isoform 4 is specifically expressed in liver.
CC Ubiquitously expressed with higher expression in kidney, liver and
CC placenta. {ECO:0000269|PubMed:15541471}.
CC -!- MISCELLANEOUS: [Isoform 2]: Non-canonical splice sites for exon 9 and
CC exon 10. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PRRC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17066.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC03467.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ427339; CAD22113.1; -; mRNA.
DR EMBL; AJ441110; CAD29585.2; -; mRNA.
DR EMBL; AJ496322; CAD42881.1; -; mRNA.
DR EMBL; AJ515158; CAD56470.1; -; mRNA.
DR EMBL; AJ515428; CAD56438.1; -; mRNA.
DR EMBL; AJ515429; CAD56439.1; -; mRNA.
DR EMBL; AK090486; BAC03467.1; ALT_FRAME; mRNA.
DR EMBL; AK057437; BAB71487.1; -; mRNA.
DR EMBL; AL831963; CAD38605.1; -; mRNA.
DR EMBL; AL832600; CAH10384.1; ALT_TERM; mRNA.
DR EMBL; CH471062; EAW62402.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62405.1; -; Genomic_DNA.
DR EMBL; BC017066; AAH17066.1; ALT_INIT; mRNA.
DR CCDS; CCDS4143.1; -. [Q96M27-1]
DR CCDS; CCDS68943.1; -. [Q96M27-3]
DR RefSeq; NP_001273737.1; NM_001286808.1. [Q96M27-3]
DR RefSeq; NP_570721.1; NM_130809.4. [Q96M27-1]
DR RefSeq; XP_006714592.1; XM_006714529.3. [Q96M27-1]
DR AlphaFoldDB; Q96M27; -.
DR SMR; Q96M27; -.
DR BioGRID; 126367; 56.
DR IntAct; Q96M27; 16.
DR MINT; Q96M27; -.
DR STRING; 9606.ENSP00000421965; -.
DR GlyGen; Q96M27; 26 sites, 2 O-linked glycans (26 sites).
DR iPTMnet; Q96M27; -.
DR MetOSite; Q96M27; -.
DR PhosphoSitePlus; Q96M27; -.
DR BioMuta; PRRC1; -.
DR DMDM; 74732288; -.
DR EPD; Q96M27; -.
DR jPOST; Q96M27; -.
DR MassIVE; Q96M27; -.
DR MaxQB; Q96M27; -.
DR PaxDb; Q96M27; -.
DR PeptideAtlas; Q96M27; -.
DR PRIDE; Q96M27; -.
DR ProteomicsDB; 77284; -. [Q96M27-1]
DR ProteomicsDB; 77285; -. [Q96M27-2]
DR ProteomicsDB; 77286; -. [Q96M27-3]
DR ProteomicsDB; 77287; -. [Q96M27-4]
DR ProteomicsDB; 77288; -. [Q96M27-5]
DR Antibodypedia; 45054; 70 antibodies from 17 providers.
DR DNASU; 133619; -.
DR Ensembl; ENST00000296666.13; ENSP00000296666.9; ENSG00000164244.21. [Q96M27-1]
DR Ensembl; ENST00000442138.6; ENSP00000392873.2; ENSG00000164244.21. [Q96M27-5]
DR Ensembl; ENST00000512635.2; ENSP00000421965.2; ENSG00000164244.21. [Q96M27-3]
DR GeneID; 133619; -.
DR KEGG; hsa:133619; -.
DR MANE-Select; ENST00000296666.13; ENSP00000296666.9; NM_130809.5; NP_570721.1.
DR UCSC; uc003kuj.6; human. [Q96M27-1]
DR CTD; 133619; -.
DR DisGeNET; 133619; -.
DR GeneCards; PRRC1; -.
DR HGNC; HGNC:28164; PRRC1.
DR HPA; ENSG00000164244; Low tissue specificity.
DR neXtProt; NX_Q96M27; -.
DR OpenTargets; ENSG00000164244; -.
DR PharmGKB; PA162400175; -.
DR VEuPathDB; HostDB:ENSG00000164244; -.
DR eggNOG; ENOG502QUZV; Eukaryota.
DR GeneTree; ENSGT00390000003837; -.
DR HOGENOM; CLU_041959_0_0_1; -.
DR InParanoid; Q96M27; -.
DR OMA; VTRTDWH; -.
DR OrthoDB; 930508at2759; -.
DR PhylomeDB; Q96M27; -.
DR TreeFam; TF343676; -.
DR PathwayCommons; Q96M27; -.
DR SignaLink; Q96M27; -.
DR BioGRID-ORCS; 133619; 25 hits in 1078 CRISPR screens.
DR ChiTaRS; PRRC1; human.
DR GenomeRNAi; 133619; -.
DR Pharos; Q96M27; Tdark.
DR PRO; PR:Q96M27; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96M27; protein.
DR Bgee; ENSG00000164244; Expressed in tibia and 193 other tissues.
DR Genevisible; Q96M27; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IBA:GO_Central.
DR GO; GO:0034199; P:activation of protein kinase A activity; IBA:GO_Central.
DR Gene3D; 3.90.950.10; -; 1.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR026533; NTPase/PRRC1.
DR InterPro; IPR026534; PRRC1.
DR PANTHER; PTHR23276; PTHR23276; 1.
DR Pfam; PF01931; NTPase_I-T; 1.
DR SUPFAM; SSF52972; SSF52972; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Phosphoprotein; Reference proteome.
FT CHAIN 1..445
FT /note="Protein PRRC1"
FT /id="PRO_0000307338"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 209
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 311
FT /note="E -> A (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15541471"
FT /id="VSP_028720"
FT VAR_SEQ 312..445
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15541471"
FT /id="VSP_028721"
FT VAR_SEQ 377
FT /note="A -> VGFLLCFFIMLQRNLHYCFQNKNLFGFFVRNMFLILFQSFFF (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028722"
FT VAR_SEQ 378..445
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028723"
FT VAR_SEQ 433..445
FT /note="AGMYKQRLPPRTV -> ENPQRAVAVHGLVEARNFPAPGDLVSLLLGTV
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15541471"
FT /id="VSP_028724"
FT VAR_SEQ 434..445
FT /note="GMYKQRLPPRTV -> DDYFPRIPKEQWQSMAWLKLEIFLPLVTW (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15541471"
FT /id="VSP_028725"
FT CONFLICT 70
FT /note="A -> T (in Ref. 4; CAH10384)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="L -> S (in Ref. 4; CAH10384)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 46701 MW; 68FFE2C1992A2361 CRC64;
MMEESGIETT PPGTPPPNPA GLAATAMSST PVPLAATSSF SSPNVSSMES FPPLAYSTPQ
PPLPPVRPSA PLPFVPPPAV PSVPPLVTSM PPPVSPSTAA AFGNPPVSHF PPSTSAPNTL
LPAPPSGPPI SGFSVGSTYD ITRGHAGRAP QTPLMPSFSA PSGTGLLPTP ITQQASLTSL
AQGTGTTSAI TFPEEQEDPR ITRGQDEASA GGIWGFIKGV AGNPMVKSVL DKTKHSVESM
ITTLDPGMAP YIKSGGELDI VVTSNKEVKV AAVRDAFQEV FGLAVVVGEA GQSNIAPQPV
GYAAGLKGAQ ERIDSLRRTG VIHEKQTAVS VENFIAELLP DKWFDIGCLV VEDPVHGIHL
ETFTQATPVP LEFVQQAQSL TPQDYNLRWS GLLVTVGEVL EKSLLNVSRT DWHMAFTGMS
RRQMIYSAAR AIAGMYKQRL PPRTV
