PRRC1_MOUSE
ID PRRC1_MOUSE Reviewed; 443 AA.
AC Q3UPH1; Q91YT1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein PRRC1;
DE AltName: Full=Proline-rich and coiled-coil-containing protein 1;
GN Name=Prrc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PRRC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH14817.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK143537; BAE25424.1; -; mRNA.
DR EMBL; BC014817; AAH14817.1; ALT_INIT; mRNA.
DR CCDS; CCDS37825.1; -.
DR RefSeq; NP_082723.2; NM_028447.3.
DR RefSeq; XP_006526350.1; XM_006526287.3.
DR RefSeq; XP_006526351.1; XM_006526288.2.
DR RefSeq; XP_006526352.1; XM_006526289.2.
DR AlphaFoldDB; Q3UPH1; -.
DR SMR; Q3UPH1; -.
DR BioGRID; 215793; 4.
DR STRING; 10090.ENSMUSP00000025490; -.
DR iPTMnet; Q3UPH1; -.
DR PhosphoSitePlus; Q3UPH1; -.
DR EPD; Q3UPH1; -.
DR jPOST; Q3UPH1; -.
DR MaxQB; Q3UPH1; -.
DR PaxDb; Q3UPH1; -.
DR PeptideAtlas; Q3UPH1; -.
DR PRIDE; Q3UPH1; -.
DR ProteomicsDB; 291801; -.
DR Antibodypedia; 45054; 70 antibodies from 17 providers.
DR DNASU; 73137; -.
DR Ensembl; ENSMUST00000025490; ENSMUSP00000025490; ENSMUSG00000024594.
DR GeneID; 73137; -.
DR KEGG; mmu:73137; -.
DR UCSC; uc008ezb.2; mouse.
DR CTD; 133619; -.
DR MGI; MGI:1916106; Prrc1.
DR VEuPathDB; HostDB:ENSMUSG00000024594; -.
DR eggNOG; ENOG502QUZV; Eukaryota.
DR GeneTree; ENSGT00390000003837; -.
DR HOGENOM; CLU_041959_0_0_1; -.
DR InParanoid; Q3UPH1; -.
DR OMA; VTRTDWH; -.
DR OrthoDB; 930508at2759; -.
DR PhylomeDB; Q3UPH1; -.
DR TreeFam; TF343676; -.
DR BioGRID-ORCS; 73137; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Prrc1; mouse.
DR PRO; PR:Q3UPH1; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q3UPH1; protein.
DR Bgee; ENSMUSG00000024594; Expressed in ureter and 251 other tissues.
DR ExpressionAtlas; Q3UPH1; baseline and differential.
DR Genevisible; Q3UPH1; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IBA:GO_Central.
DR GO; GO:0034199; P:activation of protein kinase A activity; IBA:GO_Central.
DR Gene3D; 3.90.950.10; -; 1.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR026533; NTPase/PRRC1.
DR InterPro; IPR026534; PRRC1.
DR PANTHER; PTHR23276; PTHR23276; 1.
DR Pfam; PF01931; NTPase_I-T; 1.
DR SUPFAM; SSF52972; SSF52972; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Phosphoprotein; Reference proteome.
FT CHAIN 1..443
FT /note="Protein PRRC1"
FT /id="PRO_0000307339"
FT REGION 1..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..77
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 406
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96M27"
SQ SEQUENCE 443 AA; 46298 MW; 79BFE7A17DD6F471 CRC64;
MMEESGIETT PPGTPPLHPA GLAAVPSTEA HSAATSSFSS PNVSGMESLP PHVYSTPQPS
LPPVQPSAPP PFVSMSPAPS VPLSGTSVPP SVSPSPATAF SGPPMSHFPP ATSASGALLS
APPSGPPISG FSVGTTYDIT RGHAGRAPQT PLMPSFSAPP VTGILPAPIT QQASMTSLAQ
GPGTTSAITF PEEQEDPRIN RGQDDAPAGG IWGFIKGVAG NPMVKSVLDK TKHSVESMIT
TLDPGMAPYI KSGGELDIVV TSNKEVKVAA VRDAFQEVFG LAVVVGEAGQ SNIAPQPVGY
AAGLKGAQER IDSLRRSGAI HEKQTAVSVE NFIAELLPDK WFDIGCLVVE DPVHGIRLEA
FTQATPVPLE FVQQAQSLTP QDYNLRWSGL LVTVGEVLEK SLLNVSRTDW HLAFTGMSRR
QMIYSAAKAV AGMYKQRLPP RPM
