ID   PRRP_BOVIN              Reviewed;          98 AA.
AC   P81264;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Prolactin-releasing peptide;
DE            Short=PrRP;
DE   AltName: Full=Prolactin-releasing hormone;
DE   Contains:
DE     RecName: Full=Prolactin-releasing peptide PrRP31;
DE   Contains:
DE     RecName: Full=Prolactin-releasing peptide PrRP20;
DE   Flags: Precursor;
GN   Name=PRLH; Synonyms=PRH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-52, AND AMIDATION AT
RP   PHE-53.
RC   TISSUE=Brain;
RX   PubMed=9607765; DOI=10.1038/30515;
RA   Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S.,
RA   Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T.,
RA   Nishimura O., Onda H., Fujino M.;
RT   "A prolactin-releasing peptide in the brain.";
RL   Nature 393:272-276(1998).
CC   -!- FUNCTION: Stimulates prolactin (PRL) release and regulates the
CC       expression of prolactin through its receptor GPR10. May stimulate
CC       lactotrophs directly to secrete PRL.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Medulla oblongata and hypothalamus.
CC   -!- PTM: Amidation of C-terminus is required for receptor interaction.
CC       {ECO:0000269|PubMed:9607765}.
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DR   EMBL; AB015417; BAA29025.1; -; mRNA.
DR   RefSeq; NP_777215.1; NM_174790.1.
DR   AlphaFoldDB; P81264; -.
DR   STRING; 9913.ENSBTAP00000023421; -.
DR   PaxDb; P81264; -.
DR   GeneID; 286856; -.
DR   KEGG; bta:286856; -.
DR   CTD; 51052; -.
DR   eggNOG; ENOG502S7XA; Eukaryota.
DR   InParanoid; P81264; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026194; PrRP.
DR   PANTHER; PTHR17206; PTHR17206; 1.
DR   Pfam; PF15172; Prolactin_RP; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:9607765"
FT   PEPTIDE         23..53
FT                   /note="Prolactin-releasing peptide PrRP31"
FT                   /id="PRO_0000022141"
FT   PEPTIDE         34..53
FT                   /note="Prolactin-releasing peptide PrRP20"
FT                   /id="PRO_0000022142"
FT   PROPEP          58..98
FT                   /id="PRO_0000022143"
FT   REGION          52..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9607765"
SQ   SEQUENCE   98 AA;  10544 MW;  08AC35A13B0FA908 CRC64;
     MKAVGAWLLC LLLLGLALQG AASRAHQHSM EIRTPDINPA WYAGRGIRPV GRFGRRRAAP
     GDGPRPGPRR VPACFRLEGG AEPSRALPGR LTAQLVQE