PRRP_HUMAN
ID PRRP_HUMAN Reviewed; 87 AA.
AC P81277;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Prolactin-releasing peptide;
DE Short=PrRP;
DE AltName: Full=Prolactin-releasing hormone;
DE Contains:
DE RecName: Full=Prolactin-releasing peptide PrRP31;
DE Contains:
DE RecName: Full=Prolactin-releasing peptide PrRP20;
DE Flags: Precursor;
GN Name=PRLH; Synonyms=PRH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9607765; DOI=10.1038/30515;
RA Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S.,
RA Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T.,
RA Nishimura O., Onda H., Fujino M.;
RT "A prolactin-releasing peptide in the brain.";
RL Nature 393:272-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=10498338; DOI=10.1016/s0167-0115(99)00028-2;
RA Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S.,
RA Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H., Sumino Y.,
RA Fujino M.;
RT "Tissue distribution of prolactin-releasing peptide (PrRP) and its
RT receptor.";
RL Regul. Pept. 83:1-10(1999).
CC -!- FUNCTION: Stimulates prolactin (PRL) release and regulates the
CC expression of prolactin through its receptor GPR10. May stimulate
CC lactotrophs directly to secrete PRL.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Medulla oblongata and hypothalamus.
CC {ECO:0000269|PubMed:10498338}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB015419; BAA29027.1; -; mRNA.
DR EMBL; BC069081; AAH69081.1; -; mRNA.
DR EMBL; BC069284; AAH69284.1; -; mRNA.
DR CCDS; CCDS2519.1; -.
DR RefSeq; NP_056977.1; NM_015893.1.
DR AlphaFoldDB; P81277; -.
DR STRING; 9606.ENSP00000165524; -.
DR iPTMnet; P81277; -.
DR PhosphoSitePlus; P81277; -.
DR BioMuta; PRLH; -.
DR DMDM; 8134649; -.
DR PaxDb; P81277; -.
DR PRIDE; P81277; -.
DR Antibodypedia; 2231; 51 antibodies from 14 providers.
DR DNASU; 51052; -.
DR Ensembl; ENST00000165524.1; ENSP00000165524.1; ENSG00000071677.1.
DR GeneID; 51052; -.
DR KEGG; hsa:51052; -.
DR MANE-Select; ENST00000165524.1; ENSP00000165524.1; NM_015893.1; NP_056977.1.
DR CTD; 51052; -.
DR DisGeNET; 51052; -.
DR GeneCards; PRLH; -.
DR HGNC; HGNC:17945; PRLH.
DR HPA; ENSG00000071677; Tissue enriched (brain).
DR MIM; 602663; gene.
DR neXtProt; NX_P81277; -.
DR OpenTargets; ENSG00000071677; -.
DR PharmGKB; PA134927756; -.
DR VEuPathDB; HostDB:ENSG00000071677; -.
DR eggNOG; ENOG502S7XA; Eukaryota.
DR GeneTree; ENSGT00390000005489; -.
DR HOGENOM; CLU_170457_0_0_1; -.
DR InParanoid; P81277; -.
DR OMA; QHSMEVR; -.
DR OrthoDB; 1486353at2759; -.
DR PhylomeDB; P81277; -.
DR TreeFam; TF330717; -.
DR PathwayCommons; P81277; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR SignaLink; P81277; -.
DR BioGRID-ORCS; 51052; 9 hits in 1062 CRISPR screens.
DR GeneWiki; PRLH; -.
DR GeneWiki; Prolactin-releasing_peptide; -.
DR GenomeRNAi; 51052; -.
DR Pharos; P81277; Tdark.
DR PRO; PR:P81277; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P81277; protein.
DR Bgee; ENSG00000071677; Expressed in pancreatic ductal cell and 83 other tissues.
DR ExpressionAtlas; P81277; baseline and differential.
DR Genevisible; P81277; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031861; F:prolactin-releasing peptide receptor binding; IBA:GO_Central.
DR GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl.
DR GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0002023; P:reduction of food intake in response to dietary excess; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
DR InterPro; IPR026194; PrRP.
DR PANTHER; PTHR17206; PTHR17206; 1.
DR Pfam; PF15172; Prolactin_RP; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT PEPTIDE 23..53
FT /note="Prolactin-releasing peptide PrRP31"
FT /id="PRO_0000022144"
FT PEPTIDE 34..53
FT /note="Prolactin-releasing peptide PrRP20"
FT /id="PRO_0000022145"
FT PROPEP 58..87
FT /id="PRO_0000022146"
FT MOD_RES 53
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 87 AA; 9639 MW; 229A2F3F50CF981B CRC64;
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL
GDVPKPGLRP RLTCFPLEGG AMSSQDG
