PRRP_RAT
ID PRRP_RAT Reviewed; 83 AA.
AC P81278; Q8K3Y0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Prolactin-releasing peptide;
DE Short=PrRP;
DE AltName: Full=Prolactin-releasing hormone;
DE Contains:
DE RecName: Full=Prolactin-releasing peptide PrRP31;
DE Contains:
DE RecName: Full=Prolactin-releasing peptide PrRP20;
DE Flags: Precursor;
GN Name=Prlh; Synonyms=Prh;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9607765; DOI=10.1038/30515;
RA Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S.,
RA Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T.,
RA Nishimura O., Onda H., Fujino M.;
RT "A prolactin-releasing peptide in the brain.";
RL Nature 393:272-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley;
RX PubMed=11178959; DOI=10.1006/bbrc.2001.4308;
RA Yamada M., Ozawa A., Ishii S., Shibusawa N., Hashida T., Ishizuka T.,
RA Hosoya T., Monden T., Satoh T., Mori M.;
RT "Isolation and characterization of the rat prolactin-releasing peptide
RT gene: multiple TATA boxes in the promoter region.";
RL Biochem. Biophys. Res. Commun. 281:53-56(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 2).
RC STRAIN=Sprague-Dawley; TISSUE=Hypothalamus;
RA Anderson S.T., Kokay I.C., Lang T., Grattan D.R., Curlewis J.D.;
RT "Quantitation of prolactin-releasing peptide (PrRP) mRNA expression in
RT specific brain regions during the rat oestrous cycle and in lactation.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=10498338; DOI=10.1016/s0167-0115(99)00028-2;
RA Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S.,
RA Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H., Sumino Y.,
RA Fujino M.;
RT "Tissue distribution of prolactin-releasing peptide (PrRP) and its
RT receptor.";
RL Regul. Pept. 83:1-10(1999).
CC -!- FUNCTION: Stimulates prolactin (PRL) release and regulates the
CC expression of prolactin through its receptor GPR10. May stimulate
CC lactotrophs directly to secrete PRL.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P81278-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P81278-2; Sequence=VSP_004370;
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in medulla
CC oblongata and hypothalamus. {ECO:0000269|PubMed:10498338}.
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DR EMBL; AB015418; BAA29026.1; -; mRNA.
DR EMBL; AB040613; BAB33377.1; -; Genomic_DNA.
DR EMBL; AF521930; AAM82154.1; -; mRNA.
DR PIR; JC7607; JC7607.
DR RefSeq; NP_071558.1; NM_022222.1. [P81278-1]
DR RefSeq; XP_006245540.1; XM_006245478.3. [P81278-1]
DR AlphaFoldDB; P81278; -.
DR STRING; 10116.ENSRNOP00000026912; -.
DR PaxDb; P81278; -.
DR GeneID; 63850; -.
DR KEGG; rno:63850; -.
DR UCSC; RGD:628634; rat. [P81278-1]
DR CTD; 51052; -.
DR RGD; 628634; Prlh.
DR VEuPathDB; HostDB:ENSRNOG00000019871; -.
DR eggNOG; ENOG502S7XA; Eukaryota.
DR HOGENOM; CLU_170457_0_0_1; -.
DR InParanoid; P81278; -.
DR OMA; QHSMEVR; -.
DR OrthoDB; 1486353at2759; -.
DR PhylomeDB; P81278; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR PRO; PR:P81278; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000019871; Expressed in testis and 9 other tissues.
DR Genevisible; P81278; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; TAS:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; IMP:RGD.
DR GO; GO:0005148; F:prolactin receptor binding; TAS:RGD.
DR GO; GO:0031861; F:prolactin-releasing peptide receptor binding; IMP:RGD.
DR GO; GO:0048483; P:autonomic nervous system development; ISO:RGD.
DR GO; GO:0042755; P:eating behavior; ISO:RGD.
DR GO; GO:0006112; P:energy reserve metabolic process; ISO:RGD.
DR GO; GO:0045444; P:fat cell differentiation; ISO:RGD.
DR GO; GO:0007631; P:feeding behavior; IMP:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0006629; P:lipid metabolic process; ISO:RGD.
DR GO; GO:0002023; P:reduction of food intake in response to dietary excess; IMP:MGI.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISO:RGD.
DR GO; GO:0002021; P:response to dietary excess; ISO:RGD.
DR GO; GO:0009749; P:response to glucose; ISO:RGD.
DR GO; GO:0032868; P:response to insulin; ISO:RGD.
DR GO; GO:0043434; P:response to peptide hormone; ISO:RGD.
DR GO; GO:0001894; P:tissue homeostasis; ISO:RGD.
DR InterPro; IPR026194; PrRP.
DR PANTHER; PTHR17206; PTHR17206; 1.
DR Pfam; PF15172; Prolactin_RP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT PEPTIDE 22..52
FT /note="Prolactin-releasing peptide PrRP31"
FT /id="PRO_0000022147"
FT PEPTIDE 33..52
FT /note="Prolactin-releasing peptide PrRP20"
FT /id="PRO_0000022148"
FT PROPEP 57..83
FT /id="PRO_0000022149"
FT MOD_RES 52
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT VAR_SEQ 33..83
FT /note="TPDINPAWYTGRGIRPVGRFGRRRATPRDVTGLGQLSCLPLDGRTKFSQRG
FT -> SECLTYGKQPLTSFHPFTSQMPP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_004370"
SQ SEQUENCE 83 AA; 9215 MW; D0C75A264EEE4F29 CRC64;
MALKTWLLCL LLLSLVLPGA SSRAHQHSME TRTPDINPAW YTGRGIRPVG RFGRRRATPR
DVTGLGQLSC LPLDGRTKFS QRG
