ID   PRRP_SHEEP              Reviewed;          98 AA.
AC   Q8WN12;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Prolactin-releasing peptide;
DE            Short=PrRP;
DE   AltName: Full=Prolactin-releasing hormone;
DE   Contains:
DE     RecName: Full=Prolactin-releasing peptide PrRP31;
DE   Contains:
DE     RecName: Full=Prolactin-releasing peptide PrRP20;
DE   Flags: Precursor;
GN   Name=PRLH; Synonyms=PRH;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12098662; DOI=10.1677/joe.0.1740045;
RA   Curlewis J.D., Kusters D.H.L., Barclay J.L., Anderson S.T.;
RT   "Prolactin-releasing peptide in the ewe: cDNA cloning, mRNA distribution
RT   and effects on prolactin secretion in vitro and in vivo.";
RL   J. Endocrinol. 174:45-53(2002).
CC   -!- FUNCTION: Stimulates prolactin (PRL) release and regulates the
CC       expression of prolactin through its receptor GPR10. May stimulate
CC       lactotrophs directly to secrete PRL.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: More abundantly expressed in the brainstem than the
CC       hypothalamus. {ECO:0000269|PubMed:12098662}.
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DR   EMBL; AF450453; AAL47178.1; -; mRNA.
DR   RefSeq; NP_001009434.1; NM_001009434.1.
DR   AlphaFoldDB; Q8WN12; -.
DR   STRING; 9940.ENSOARP00000020428; -.
DR   Ensembl; ENSOART00020003332; ENSOARP00020002772; ENSOARG00020002190.
DR   GeneID; 443466; -.
DR   KEGG; oas:443466; -.
DR   CTD; 51052; -.
DR   eggNOG; ENOG502S7XA; Eukaryota.
DR   OrthoDB; 1486353at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl.
DR   GO; GO:0042755; P:eating behavior; IEA:Ensembl.
DR   GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
DR   GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0002021; P:response to dietary excess; IEA:Ensembl.
DR   GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
DR   InterPro; IPR026194; PrRP.
DR   PANTHER; PTHR17206; PTHR17206; 1.
DR   Pfam; PF15172; Prolactin_RP; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         23..53
FT                   /note="Prolactin-releasing peptide PrRP31"
FT                   /id="PRO_0000022150"
FT   PEPTIDE         34..53
FT                   /note="Prolactin-releasing peptide PrRP20"
FT                   /id="PRO_0000022151"
FT   PROPEP          58..98
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000022152"
FT   MOD_RES         53
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10513 MW;  2A53331ED62CAAB5 CRC64;
     MKAVGAWLLC LLLLGLALQG AASRAHQHSM EIRTPDINPA WYAGRGIRPV GRFGRRRAAP
     GDGPRPGPRR ELACIPLEGG AEPSRALLGR LTAQLVQE