PRRT4_HUMAN
ID PRRT4_HUMAN Reviewed; 899 AA.
AC C9JH25; A4D0Z9; C9JVW7;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Proline-rich transmembrane protein 4;
DE Flags: Precursor;
GN Name=PRRT4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=C9JH25-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C9JH25-2; Sequence=VSP_039273, VSP_039275;
CC Name=3;
CC IsoId=C9JH25-3; Sequence=VSP_039274;
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DR EMBL; AC010655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236947; EAL24313.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83645.1; -; Genomic_DNA.
DR EMBL; BC063892; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS47698.2; -. [C9JH25-2]
DR CCDS; CCDS55160.1; -. [C9JH25-1]
DR RefSeq; NP_001108198.2; NM_001114726.2. [C9JH25-2]
DR RefSeq; NP_001167635.1; NM_001174164.1. [C9JH25-1]
DR RefSeq; XP_005250399.1; XM_005250342.3. [C9JH25-1]
DR RefSeq; XP_005250400.1; XM_005250343.3. [C9JH25-1]
DR RefSeq; XP_006716048.1; XM_006715985.3. [C9JH25-1]
DR RefSeq; XP_016867694.1; XM_017012205.1. [C9JH25-1]
DR RefSeq; XP_016867695.1; XM_017012206.1. [C9JH25-2]
DR AlphaFoldDB; C9JH25; -.
DR BioGRID; 135071; 14.
DR IntAct; C9JH25; 4.
DR STRING; 9606.ENSP00000415026; -.
DR GlyGen; C9JH25; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; C9JH25; -.
DR PhosphoSitePlus; C9JH25; -.
DR BioMuta; PRRT4; -.
DR jPOST; C9JH25; -.
DR MassIVE; C9JH25; -.
DR PaxDb; C9JH25; -.
DR PeptideAtlas; C9JH25; -.
DR PRIDE; C9JH25; -.
DR ProteomicsDB; 10169; -. [C9JH25-1]
DR ProteomicsDB; 10170; -. [C9JH25-2]
DR ProteomicsDB; 10171; -. [C9JH25-3]
DR Antibodypedia; 67265; 71 antibodies from 14 providers.
DR DNASU; 401399; -.
DR Ensembl; ENST00000446477.6; ENSP00000415026.2; ENSG00000224940.9. [C9JH25-1]
DR Ensembl; ENST00000489835.6; ENSP00000419296.2; ENSG00000224940.9. [C9JH25-2]
DR Ensembl; ENST00000535159.5; ENSP00000445239.1; ENSG00000224940.9. [C9JH25-1]
DR GeneID; 401399; -.
DR KEGG; hsa:401399; -.
DR UCSC; uc022akx.2; human. [C9JH25-1]
DR CTD; 401399; -.
DR GeneCards; PRRT4; -.
DR HGNC; HGNC:37280; PRRT4.
DR HPA; ENSG00000224940; Tissue enriched (bone).
DR neXtProt; NX_C9JH25; -.
DR OpenTargets; ENSG00000224940; -.
DR PharmGKB; PA165618245; -.
DR VEuPathDB; HostDB:ENSG00000224940; -.
DR eggNOG; ENOG502QU49; Eukaryota.
DR GeneTree; ENSGT00730000111591; -.
DR HOGENOM; CLU_351937_0_0_1; -.
DR InParanoid; C9JH25; -.
DR OMA; ARCWAKL; -.
DR OrthoDB; 921831at2759; -.
DR PhylomeDB; C9JH25; -.
DR PathwayCommons; C9JH25; -.
DR BioGRID-ORCS; 401399; 21 hits in 1067 CRISPR screens.
DR ChiTaRS; PRRT4; human.
DR GenomeRNAi; 401399; -.
DR Pharos; C9JH25; Tdark.
DR PRO; PR:C9JH25; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; C9JH25; protein.
DR Bgee; ENSG00000224940; Expressed in bone marrow and 90 other tissues.
DR ExpressionAtlas; C9JH25; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR043542; Prrt4-like.
DR PANTHER; PTHR35578:SF1; PTHR35578:SF1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..899
FT /note="Proline-rich transmembrane protein 4"
FT /id="PRO_0000394498"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 110..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 641
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RU40"
FT VAR_SEQ 370..575
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_039274"
FT VAR_SEQ 370..429
FT /note="VGALFGLVALLALLALALLPWRCPPGAPCLALLDLLLLSAGTTRAFPLFYDA
FT YGHRDRLP -> RLHRGLPPALPNQPATQHRGGPLQRGPACAWPLPGPCLRGRSAWART
FT LPHRLAGDRGQGQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039273"
FT VAR_SEQ 430..899
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039275"
SQ SEQUENCE 899 AA; 92712 MW; 4E03C2B27A57A772 CRC64;
MARHGCLGLG LFCCVLFAAT VGPQPTPSIP GAPATTLTPV PQSEASMLSL NLGLNFKFHL
RGPAAVWGSP VTETQPLSLG PGQEPGEEVA SGLRTDPLWE LLVGSSGNSL TEWGSTEGGS
KPRASSLLPE STSRRSGPSD GPTAPYQPRR STVTWDTALM VTALPSSAPR PHQSELELKF
DMALRAGAAP TLGHRTLPLL PSLRASLAEI AGRLGPFGFF GTTLSPLRNF SGLSPPGETT
STSSASGVSG SLGFLGTTLS LPPYSLERKL SSPSPLDPAA SLSFASIATT SLDPTVPISG
PDDLSPPASL GNPSGQPECG PGSCSVGELP EREGQPPEAP RPLFFLTLEA DWAEARARWG
LAWEAHVYGV GALFGLVALL ALLALALLPW RCPPGAPCLA LLDLLLLSAG TTRAFPLFYD
AYGHRDRLPA LAWLLLQDLP LPCLAAGLGL ACLLLARPRP PRCPTGLAAL LLLGLGLAAA
AALGSAAHRP LRPLRLASRG LHAFLAAFLS GLLLALSCWG GRRRRAGAPL GGSGFKGATP
LPQGRSPFAP RESWRRAART APVAGTFGLL SGALQGYEVL HALGYGGQSG LEGPWPWWAF
QLGLRLGEVG VALPLALLGL YPALCSPRVP PRCWAKLFRL SPGHAAPLLP GGWVTGPPDK
EPLGSAIARG DAELLQLCAL AGPGPDLLLQ GGGCRGFEGA AANPAPSPAS SPCSDYTVDF
RPPSPINLRR SIEEALCSEA LLAPGLFQGP AFEDALPGLG LYRTASLGTG GRASERSGEA
SGPAAPPELP SPGAWPAGSS VSSGSFCGLS RDSSSMLLCS SPDRPPRCPL VCVLSPPRPS
GSSPSLPASG SYQALSPPSR DSPEPASELQ AEEALLQEQF LDACRQIDEL SVGSDTIDL
