PRRT4_MOUSE
ID PRRT4_MOUSE Reviewed; 902 AA.
AC B2RU40; E9QKZ9;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Proline-rich transmembrane protein 4;
DE Flags: Precursor;
GN Name=Prrt4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC153909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140954; AAI40955.1; -; mRNA.
DR CCDS; CCDS51734.1; -.
DR RefSeq; NP_001094913.1; NM_001101443.1.
DR RefSeq; XP_006505026.1; XM_006504963.3.
DR RefSeq; XP_006505027.1; XM_006504964.2.
DR AlphaFoldDB; B2RU40; -.
DR STRING; 10090.ENSMUSP00000123751; -.
DR iPTMnet; B2RU40; -.
DR PhosphoSitePlus; B2RU40; -.
DR PaxDb; B2RU40; -.
DR PRIDE; B2RU40; -.
DR ProteomicsDB; 291673; -.
DR Antibodypedia; 67265; 71 antibodies from 14 providers.
DR Ensembl; ENSMUST00000159200; ENSMUSP00000123751; ENSMUSG00000079654.
DR GeneID; 101359; -.
DR KEGG; mmu:101359; -.
DR UCSC; uc009bcz.2; mouse.
DR CTD; 401399; -.
DR MGI; MGI:2141677; Prrt4.
DR VEuPathDB; HostDB:ENSMUSG00000079654; -.
DR eggNOG; ENOG502QU49; Eukaryota.
DR GeneTree; ENSGT00730000111591; -.
DR HOGENOM; CLU_351937_0_0_1; -.
DR InParanoid; B2RU40; -.
DR OMA; ARCWAKL; -.
DR OrthoDB; 921831at2759; -.
DR BioGRID-ORCS; 101359; 7 hits in 72 CRISPR screens.
DR PRO; PR:B2RU40; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; B2RU40; protein.
DR Bgee; ENSMUSG00000079654; Expressed in epithelium of lens and 45 other tissues.
DR Genevisible; B2RU40; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR043542; Prrt4-like.
DR PANTHER; PTHR35578:SF1; PTHR35578:SF1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..902
FT /note="Proline-rich transmembrane protein 4"
FT /id="PRO_0000394499"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..521
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 72..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 642
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 331
FT /note="L -> P (in Ref. 2; AAI40955)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="I -> T (in Ref. 2; AAI40955)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 902 AA; 93979 MW; B7299154823CF307 CRC64;
MAGRSCLELG LFCWVLLAVP VGPQPASSVP GAPLTTLTPP PQSEASMLSL NLGLNFKFHL
RGPAAVWGNP VTETHPLSPG LGQESEEEEE GDLRTDPLWE LLVGSPGNYL PEWGSAEGSF
TPWASSLPPE STSRLSGPTK RPTAHSQPRM GTVTWATALT ATAPPTSAPR PHQSELELKF
DVALRAGAAP TLGHRSLPLL PSLRASLAEI AGRLGPFGFF GTTVSPLRNF SRQSYPGTTA
HPSFAFEVSD SPGLFGTTGS RPPPLLERKF SSPSLLDSVA SPSSASVKTT PVQQDPTVST
SGPDELSPAS FGNPSTQPGC EPGSCSEPEL LDDLGQPPAS PLPLFFLTLE ADWAEARARW
GLAWEAHVYG AGALFGLVAL LALLALALLP WRCPPGAPCL ALLDLLLLSA GTTRAFPLFY
DAYGHRDRLP TLVWLLLQDL PLPCLAAGLG LACLLLARPR TPRCPAGLAA LLLLGLGLAA
AAALGSAVHR PLRPLRLASR GLHAFLAAFL SGLLLALSCW GGRRRRAGAP LGGAGFKGAT
PVPQVRSPFA PRESWRRAAR TAPVAGTFGL LSGALQGYEV LHALGYGSQA GLEGPWPWWA
FQLGLRLGEV GVALPLALLG LYPALCSPRV PRRCWAKLFR LSPGHAAPLL PGGWVPGIPD
KEPLGSAIAR GDAELLQLCA LAGPGPDLLL QGGGCRGFEG AGANPTQSTA SSPSSDCTVD
FRPPSPINLR RSIEEALCSE ALLAPGLFQG PAFGEALPGL GLYRTISLGN KIGAGPSEKS
ENVPGSPAPP ELPSPGAWPP GSSASSGSLC GLSRDSSSML LCSSPDRPPR CPLVCVLSPP
RPSESSPSLP ASGSYQALSP PSRDSPEHAS ELQAEEALLQ EQFLDACRQI DELSMGSDTI
DL
