PRRT4_RAT
ID PRRT4_RAT Reviewed; 902 AA.
AC D4A9R4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Proline-rich transmembrane protein 4;
DE Flags: Precursor;
GN Name=Prrt4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC096035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473959; EDM15206.1; -; Genomic_DNA.
DR RefSeq; NP_001102696.1; NM_001109226.1.
DR RefSeq; XP_006236282.1; XM_006236220.3.
DR AlphaFoldDB; D4A9R4; -.
DR STRING; 10116.ENSRNOP00000057108; -.
DR iPTMnet; D4A9R4; -.
DR PhosphoSitePlus; D4A9R4; -.
DR PaxDb; D4A9R4; -.
DR Ensembl; ENSRNOT00000060362; ENSRNOP00000057108; ENSRNOG00000039388.
DR GeneID; 500059; -.
DR KEGG; rno:500059; -.
DR UCSC; RGD:1559885; rat.
DR CTD; 401399; -.
DR RGD; 1559885; Prrt4.
DR eggNOG; ENOG502QU49; Eukaryota.
DR GeneTree; ENSGT00730000111591; -.
DR HOGENOM; CLU_351937_0_0_1; -.
DR InParanoid; D4A9R4; -.
DR OMA; ARCWAKL; -.
DR OrthoDB; 921831at2759; -.
DR PhylomeDB; D4A9R4; -.
DR PRO; PR:D4A9R4; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Proteomes; UP000234681; Chromosome 4.
DR Bgee; ENSRNOG00000039388; Expressed in cerebellum and 3 other tissues.
DR Genevisible; D4A9R4; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR043542; Prrt4-like.
DR PANTHER; PTHR35578:SF1; PTHR35578:SF1; 1.
PE 3: Inferred from homology;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..902
FT /note="Proline-rich transmembrane protein 4"
FT /id="PRO_0000394500"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..521
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 120..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 642
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RU40"
SQ SEQUENCE 902 AA; 93830 MW; 94A89CAA4B9DC53D CRC64;
MAGRGCLELG LFCWVLLAVP VGPQPASSVP GAPLTTLTPP PQSEASMLSL NLGLNFKFHL
RGPAAVWGSP VTETHPLSPG LGQESEEDLE GDLRTDPLWE LLVGSPGNYV PEWGSAEGSF
TPWASSLPPE STSPLSGPTK RPTAPSQPRM STVTWATALT ATAPPTSAPR PRQSELELKF
DVALRAGAAP TLGHRSLPLL PSLRASLAEI AGRLGPFGFF GTTLSPLRNF SSQSYQGTTA
QPSFASEVSD FPGLFGTTGS LPPPLLERKF SSPSPLDSVA SPSSASIKTT PVQHDPTVST
SDPDELSPAS FGSPSAQPGC EPGSCSEPEL SDDSGQPPAS PLPLFFLTLE ADWAEARARW
GLAWEAHVYG AGALFGLVAL LALLSLALLP WRCPPGAPCL ALLDLLLLSA GTTRAFPLFY
DAYGHRDRLP ALAWLLLQDL PLPCLAAGLG LACLLLARPR TPRCPIGLAA LLLLGLGLAA
AAALGSAVHR PLRPLRLASR GLHAFLAAFL SGLLLALSCW GGRRRRAGAP LGGSGFKGAT
PVPQVRSPFA PRESWRRAAR TAPVAGTFGL LSGALQGYEV LHALGYGGQT GLEGPWPWWA
FQLGLRLGEV GVALPLALLG LYPALCSPRV PRRCWAKLFR LSPGHAAPLL PGGWVPGIRD
KEPLGSAIAR GDAELLQLCA LAGPGPDLLL QGGSCPGFEG ARANTTQSPA SSPSSDCTVD
FRPPSPINLR RSIEEALCSE ALLAPGLFQG PAFGDALSGL GLYRTISLGN KTGAGPSEKS
EKVPGSPAPP ELPSPGAWPP GSSASSGSLC GLSRDSSSML LCSSPDRPPR CPLVCVLSPP
RPSESSPSLP ASGSYQALSP PSRDSPEHAS ELQAEEALLQ EQFLDACRQI DELSMGSDTI
DL
