PRRX1_CHICK
ID PRRX1_CHICK Reviewed; 245 AA.
AC Q05437; Q91368;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Paired mesoderm homeobox protein 1;
DE AltName: Full=GMHOX;
DE AltName: Full=Homeobox protein MHOX;
DE AltName: Full=Paired-related homeobox protein 1;
DE Short=PRX-1;
GN Name=PRRX1; Synonyms=MHOX, PMX1, PRX1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Limb bud;
RX PubMed=8101172; DOI=10.1006/dbio.1993.1184;
RA Nohno T., Koyama E., Myokai F., Taniguchi S., Ohuchi H., Saito T., Noji S.;
RT "A chicken homeobox gene related to Drosophila paired is predominantly
RT expressed in the developing limb.";
RL Dev. Biol. 158:254-264(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryonic heart;
RX PubMed=7906232; DOI=10.1006/dbio.1994.1037;
RA Kuratani S., Martin J.F., Wawersik S., Lilly B., Eichele G., Olson E.N.;
RT "The expression pattern of the chick homeobox gene gMHox suggests a role in
RT patterning of the limbs and face and in compartmentalization of somites.";
RL Dev. Biol. 161:357-369(1994).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=7577675; DOI=10.1016/0925-4773(95)00389-i;
RA Leussink B., Brouwer A., el Khattabi M., Poelmann R.E.,
RA Gittenberger-De Groot A.C., Meijlink F.;
RT "Expression patterns of the paired-related homeobox genes MHox/Prx1 and
RT S8/Prx2 suggest roles in development of the heart and the forebrain.";
RL Mech. Dev. 52:51-64(1995).
RN [4]
RP INTERACTION WITH MAF AND MAFB.
RX PubMed=11036080; DOI=10.1074/jbc.m007643200;
RA Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.;
RT "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA
RT binding, transactivation, and transforming activities.";
RL J. Biol. Chem. 276:819-826(2001).
CC -!- FUNCTION: May participate in maintenance of mesenchymal cell lineages
CC derived from both mesoderm and the neural crest and in patterning of
CC the limbs and the face.
CC -!- SUBUNIT: Interacts with MAF and MAFB. {ECO:0000269|PubMed:11036080}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the mesodermal cells of
CC the limb bud, visceral arches and craniofacial process, and at lower
CC levels, in cranial mesenchyme, upper and lower eyelids, somites and
CC cartilage of vertebra. Also found in the heart, especially the
CC developing semilunar and atrioventricular valves and in the brain, in a
CC distinct region of the ventral part of the hypothalamus as well as in a
CC broader region of the telencephalon.
CC -!- DEVELOPMENTAL STAGE: At stage 10, expressed in the neural tube
CC throughout the mesoderm. By early stage 13, expression becomes
CC restricted to the lateral mesoderm in the trunk region and in the
CC cranial region, to the dermomyotome, to the somatic mseoderm-derived
CC pericardium and to a group of cells located ventral to the
CC dermomyotome. Expression continues at high levels in the dermatome. In
CC later stages, high expression found in the limb bud mesenchyme
CC pharyngeal arches, the maxillary arches and the frontonasal mass and to
CC a lesser extent, in the aorta, cardiac valve mesenchyme, the
CC pericardial wall and the ventral foregut wall.
CC {ECO:0000269|PubMed:7577675}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; D13433; BAA02695.1; -; mRNA.
DR EMBL; S69088; AAB29880.1; -; mRNA.
DR PIR; I51226; I51226.
DR RefSeq; NP_001007822.1; NM_001007821.1.
DR RefSeq; NP_001264653.1; NM_001277724.1.
DR AlphaFoldDB; Q05437; -.
DR SMR; Q05437; -.
DR MINT; Q05437; -.
DR STRING; 9031.ENSGALP00000005255; -.
DR PaxDb; Q05437; -.
DR Ensembl; ENSGALT00000005264; ENSGALP00000005255; ENSGALG00000003324.
DR GeneID; 373941; -.
DR KEGG; gga:373941; -.
DR CTD; 5396; -.
DR VEuPathDB; HostDB:geneid_373941; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000159466; -.
DR InParanoid; Q05437; -.
DR OMA; YAHIMER; -.
DR OrthoDB; 1413050at2759; -.
DR PhylomeDB; Q05437; -.
DR PRO; PR:Q05437; -.
DR Proteomes; UP000000539; Chromosome 8.
DR Bgee; ENSGALG00000003324; Expressed in ovary and 6 other tissues.
DR ExpressionAtlas; Q05437; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0048664; P:neuron fate determination; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0100026; P:positive regulation of DNA repair by transcription from RNA polymerase II promoter; IEA:Ensembl.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0070570; P:regulation of neuron projection regeneration; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043378; PRRX1/2.
DR PANTHER; PTHR46385; PTHR46385; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..245
FT /note="Paired mesoderm homeobox protein 1"
FT /id="PRO_0000049254"
FT DNA_BIND 94..153
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 50..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 222..235
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 67..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 155
FT /note="Missing (in Ref. 1; BAA02695)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27201 MW; B9223AD380AD244A CRC64;
MASSYAHAME RQALLPARLD GPAGLDNLQA KKNFSVSHLL DLEEAGDMVA AQGDEGGGEP
GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD
AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLASK NASLLKSYSG DVTAVEQPIV
PRPAPRPTDY LSWGTASPYS AMATYSTTCT NASPAQGMNM ANSIANLRLK AKEYSLQRNQ
VPTVN
