ID   ATG33_LACTC             Reviewed;         206 AA.
AC   C5DNL7;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Autophagy-related protein 33;
GN   Name=ATG33; OrderedLocusNames=KLTH0G18172g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Involved in the selective degradation of mitochondria via
CC       autophagy during starvation and at post-log phase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ATG33 family. {ECO:0000305}.
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DR   EMBL; CU928171; CAR25378.1; -; Genomic_DNA.
DR   RefSeq; XP_002555815.1; XM_002555769.1.
DR   AlphaFoldDB; C5DNL7; -.
DR   STRING; 559295.C5DNL7; -.
DR   EnsemblFungi; CAR25378; CAR25378; KLTH0G18172g.
DR   GeneID; 8294110; -.
DR   KEGG; lth:KLTH0G18172g; -.
DR   eggNOG; ENOG502S27M; Eukaryota.
DR   HOGENOM; CLU_105986_1_0_1; -.
DR   InParanoid; C5DNL7; -.
DR   OMA; PYLLYSM; -.
DR   OrthoDB; 1518202at2759; -.
DR   Proteomes; UP000002036; Chromosome G.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Autophagy-related protein 33"
FT                   /id="PRO_0000399767"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   206 AA;  20767 MW;  53B5012FA18C2C7F CRC64;
     MSVCLAVTKT VAVSSLGIYC GMLTSACVAS YAAPVDVLTQ LAKPARVIAR VGGALAAVSS
     AFFALSYFGA PAHWRHPYLL YGMLVAPVSA AYVAVVARVR GAHCRRACEK RRAQSASVHA
     STPASAAPEP ALDDSVVDLG AAAAAAESAP ETHVTSAEHV PVSHHVTPAS AACARAAARH
     AAVLLLPAAA GLLGSVLGLY GEGLFV