PRRX1_RAT
ID PRRX1_RAT Reviewed; 245 AA.
AC P63014; P43271; Q02810; Q643W9;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Paired mesoderm homeobox protein 1;
DE AltName: Full=Paired-related homeobox protein 1;
DE Short=PRX-1;
DE Short=rHox;
GN Name=Prrx1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=8749718; DOI=10.1002/jcb.240590409;
RA Hu Y., Flanagan J., Brennan D.P., Zhou H., Ng K.W., Eisman J.A.,
RA Morrison N.A.;
RT "rHox: a homeobox gene expressed in osteoblastic cells.";
RL J. Cell. Biochem. 59:486-497(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=Sprague-Dawley;
RA Shi Z., Rockey D.C.;
RT "Rat Prx-1 is expressed in activated HSC and involved in regulation of
RT smooth muscle alpha actin promoter activity.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Acts as a transcriptional regulator of muscle creatine kinase
CC (MCK) and so has a role in the establishment of diverse mesodermal
CC muscle types. The protein binds to an A/T-rich element in the muscle
CC creatine enhancer (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Prx1a;
CC IsoId=P63014-1; Sequence=Displayed;
CC Name=2; Synonyms=Prx1b;
CC IsoId=P63014-2; Sequence=VSP_053544;
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; S82911; AAB46839.1; -; mRNA.
DR EMBL; AY730764; AAU21314.1; -; mRNA.
DR EMBL; CH473958; EDM09378.1; -; Genomic_DNA.
DR RefSeq; NP_722543.1; NM_153821.1. [P63014-1]
DR RefSeq; XP_006250213.1; XM_006250151.3. [P63014-2]
DR AlphaFoldDB; P63014; -.
DR SMR; P63014; -.
DR STRING; 10116.ENSRNOP00000004950; -.
DR iPTMnet; P63014; -.
DR PhosphoSitePlus; P63014; -.
DR PaxDb; P63014; -.
DR Ensembl; ENSRNOT00000004950; ENSRNOP00000004950; ENSRNOG00000003720. [P63014-2]
DR Ensembl; ENSRNOT00000082385; ENSRNOP00000075169; ENSRNOG00000003720. [P63014-1]
DR GeneID; 266813; -.
DR KEGG; rno:266813; -.
DR UCSC; RGD:628884; rat. [P63014-1]
DR CTD; 5396; -.
DR RGD; 628884; Prrx1.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000159466; -.
DR HOGENOM; CLU_087323_0_0_1; -.
DR InParanoid; P63014; -.
DR OMA; YAHIMER; -.
DR OrthoDB; 1413050at2759; -.
DR PhylomeDB; P63014; -.
DR TreeFam; TF351612; -.
DR PRO; PR:P63014; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Proteomes; UP000234681; Chromosome 13.
DR Bgee; ENSRNOG00000003720; Expressed in esophagus and 17 other tissues.
DR Genevisible; P63014; RN.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0071837; F:HMG box domain binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:RGD.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR GO; GO:0048844; P:artery morphogenesis; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; ISO:RGD.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISO:RGD.
DR GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0048664; P:neuron fate determination; ISO:RGD.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; ISO:RGD.
DR GO; GO:0100026; P:positive regulation of DNA repair by transcription from RNA polymerase II promoter; ISO:RGD.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISO:RGD.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0070570; P:regulation of neuron projection regeneration; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043378; PRRX1/2.
DR PANTHER; PTHR46385; PTHR46385; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Developmental protein; DNA-binding;
KW Homeobox; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..245
FT /note="Paired mesoderm homeobox protein 1"
FT /id="PRO_0000049253"
FT DNA_BIND 94..153
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 222..235
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 67..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 160
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63013"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 200..245
FT /note="SAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN -> RS
FT SSLPRCCLHEGLHNGF (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_053544"
SQ SEQUENCE 245 AA; 27269 MW; FF867F0D856E1115 CRC64;
MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA
GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD
AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV
PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ
VPTVN
