ID   PRRX2_CHICK             Reviewed;         165 AA.
AC   Q90963;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Paired mesoderm homeobox protein 2;
DE            Short=PRX-2;
DE   Flags: Fragment;
GN   Name=PRRX2; Synonyms=PMX2, PRX2, S8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7577675; DOI=10.1016/0925-4773(95)00389-i;
RA   Leussink B., Brouwer A., el Khattabi M., Poelmann R.E.,
RA   Gittenberger-De Groot A.C., Meijlink F.;
RT   "Expression patterns of the paired-related homeobox genes MHox/Prx1 and
RT   S8/Prx2 suggest roles in development of the heart and the forebrain.";
RL   Mech. Dev. 52:51-64(1995).
CC   -!- FUNCTION: May play a role in development of the heart.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Cranial mesenchyme, limb buds, axial mesoderm, and
CC       branchial arches and their derivatives. Also found in the heart
CC       especially in the ventricular septum and ductus arteriosus.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels in 8.5 day embryos in the
CC       mandibular arch while a lower expression is seen in the extraembryonic
CC       mesoderm. Expression is abundant at days 8.5 and 9.5 in the developing
CC       visceral arches and the splanchnic mesoderm surrounding the gut.
CC       Present in the myocardium from days 8.5-12.5. At day 14.5 present in
CC       valves and extensively in the ventricular septum.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; X79695; CAA56136.1; -; mRNA.
DR   PIR; S49440; S49440.
DR   AlphaFoldDB; Q90963; -.
DR   SMR; Q90963; -.
DR   STRING; 9031.ENSGALP00000041949; -.
DR   PaxDb; Q90963; -.
DR   VEuPathDB; HostDB:geneid_396314; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q90963; -.
DR   PhylomeDB; Q90963; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043378; PRRX1/2.
DR   PANTHER; PTHR46385; PTHR46385; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..165
FT                   /note="Paired mesoderm homeobox protein 2"
FT                   /id="PRO_0000049257"
FT   DNA_BIND        16..75
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           142..155
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   NON_TER         1
SQ   SEQUENCE   165 AA;  18691 MW;  729F948BC53653CA CRC64;
     ESLSPSRGVA KRKKKQRRNR TTFNSSQLQA LERVFERTHY PDAFVREELA RRVNLSEARV
     QVWFQNRRAK FRRNERAMLA NRSASLLKSY SQEAAIEQPM APRPTALSPE YLSWSSSSPY
     STVPSYSSSG TATAAQGVNM ANSIASLRLK AKEFSLHQNQ VPTVN