PRRX2_MOUSE
ID PRRX2_MOUSE Reviewed; 247 AA.
AC Q06348; Q61651;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Paired mesoderm homeobox protein 2;
DE Short=PRX-2;
DE AltName: Full=Homeobox protein S8;
GN Name=Prrx2; Synonyms=Prx2, S8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Meijlink F., ten Berge D., Brouwer A., Bleys R.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 84-247.
RC TISSUE=Spleen;
RX PubMed=1680375; DOI=10.1016/0925-4773(91)90089-o;
RA Opstelten D.-J.E., Vogels R., Robert B., Kalkhoven E., Zwartkruis F.,
RA de Laaf L., Destree O.H., Deschamps J., Lawson K.A., Meijlink F.;
RT "The mouse homeobox gene, S8, is expressed during embryogenesis
RT predominantly in mesenchyme.";
RL Mech. Dev. 34:29-41(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 133-157.
RX PubMed=2901346; DOI=10.1002/j.1460-2075.1988.tb03052.x;
RA Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
RT "Expression of multiple homeobox genes within diverse mammalian
RT haemopoietic lineages.";
RL EMBO J. 7:2131-2138(1988).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- TISSUE SPECIFICITY: In the embryo, expressed in craniofacial
CC mesenchyme, limb, heart, somites and sclerotomes. Absent from central
CC and peripheral nervous systems, splanchnopleure and ectodermal
CC derivatives.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X52875; CAA37055.1; -; mRNA.
DR EMBL; X14572; CAA32710.1; ALT_SEQ; mRNA.
DR CCDS; CCDS15888.1; -.
DR PIR; I48410; S18038.
DR RefSeq; NP_033142.2; NM_009116.2.
DR AlphaFoldDB; Q06348; -.
DR SMR; Q06348; -.
DR BioGRID; 203059; 3.
DR IntAct; Q06348; 1.
DR MINT; Q06348; -.
DR STRING; 10090.ENSMUSP00000040332; -.
DR PhosphoSitePlus; Q06348; -.
DR MaxQB; Q06348; -.
DR PaxDb; Q06348; -.
DR PRIDE; Q06348; -.
DR ProteomicsDB; 291569; -.
DR DNASU; 20204; -.
DR GeneID; 20204; -.
DR KEGG; mmu:20204; -.
DR CTD; 51450; -.
DR MGI; MGI:98218; Prrx2.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; Q06348; -.
DR OrthoDB; 1413050at2759; -.
DR PhylomeDB; Q06348; -.
DR BioGRID-ORCS; 20204; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Prrx2; mouse.
DR PRO; PR:Q06348; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q06348; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0071837; F:HMG box domain binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IDA:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048844; P:artery morphogenesis; IGI:MGI.
DR GO; GO:0051216; P:cartilage development; IGI:MGI.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:MGI.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IGI:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IGI:MGI.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IGI:MGI.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IGI:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IGI:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043378; PRRX1/2.
DR PANTHER; PTHR46385; PTHR46385; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..247
FT /note="Paired mesoderm homeobox protein 2"
FT /id="PRO_0000049256"
FT DNA_BIND 98..157
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 224..237
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
SQ SEQUENCE 247 AA; 26427 MW; 640FFC2E7FC2F61B CRC64;
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR AAGPVSGPAE
ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR NRTTFNSSQL QALERVFERT
HYPDAFVREE LARRVNLSEA RVQVWFQNRR AKFRRNERAM LATRSASLLK SYGQEAAIEQ
PVAPRPTTMS PDYLSWPASS PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH
SQVPTVN
