PRS10_CAEEL
ID PRS10_CAEEL Reviewed; 406 AA.
AC O17071; Q5F4U7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Probable 26S proteasome regulatory subunit 10B;
DE AltName: Full=26S proteasome AAA-ATPase subunit rpt-4;
DE AltName: Full=Proteasome regulatory particle ATPase-like protein 4;
GN Name=rpt-4; ORFNames=F23F1.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC complex confers ATP dependency and substrate specificity to the 26S
CC complex (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O17071; O17071: rpt-4; NbExp=4; IntAct=EBI-320304, EBI-320304;
CC O17071; O76371: rpt-5; NbExp=10; IntAct=EBI-320304, EBI-317201;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O17071-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O17071-2; Sequence=VSP_015558;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; FO080251; CCD62357.1; -; Genomic_DNA.
DR EMBL; FO080251; CCD62358.1; -; Genomic_DNA.
DR PIR; T32268; T32268.
DR RefSeq; NP_001022113.1; NM_001026942.3. [O17071-1]
DR RefSeq; NP_001022114.1; NM_001026943.3. [O17071-2]
DR AlphaFoldDB; O17071; -.
DR SMR; O17071; -.
DR BioGRID; 38764; 51.
DR IntAct; O17071; 9.
DR STRING; 6239.F23F1.8a; -.
DR iPTMnet; O17071; -.
DR EPD; O17071; -.
DR PaxDb; O17071; -.
DR PeptideAtlas; O17071; -.
DR EnsemblMetazoa; F23F1.8a.1; F23F1.8a.1; WBGene00004504. [O17071-1]
DR EnsemblMetazoa; F23F1.8b.1; F23F1.8b.1; WBGene00004504. [O17071-2]
DR GeneID; 173384; -.
DR KEGG; cel:CELE_F23F1.8; -.
DR UCSC; F23F1.8a; c. elegans. [O17071-1]
DR CTD; 173384; -.
DR WormBase; F23F1.8a; CE29280; WBGene00004504; rpt-4. [O17071-1]
DR WormBase; F23F1.8b; CE09608; WBGene00004504; rpt-4. [O17071-2]
DR eggNOG; KOG0651; Eukaryota.
DR GeneTree; ENSGT01020000230346; -.
DR InParanoid; O17071; -.
DR OMA; YNMTTFE; -.
DR OrthoDB; 571919at2759; -.
DR PhylomeDB; O17071; -.
DR Reactome; R-CEL-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-CEL-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-CEL-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-CEL-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-CEL-382556; ABC-family proteins mediated transport.
DR Reactome; R-CEL-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-CEL-4641258; Degradation of DVL.
DR Reactome; R-CEL-5632684; Hedgehog 'on' state.
DR Reactome; R-CEL-5689603; UCH proteinases.
DR Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR Reactome; R-CEL-68949; Orc1 removal from chromatin.
DR Reactome; R-CEL-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-CEL-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-CEL-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-CEL-8951664; Neddylation.
DR Reactome; R-CEL-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-CEL-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:O17071; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004504; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0031597; C:cytosolic proteasome complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; ISS:WormBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0036402; F:proteasome-activating activity; IBA:GO_Central.
DR GO; GO:0045899; P:positive regulation of RNA polymerase II transcription preinitiation complex assembly; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
DR GO; GO:0031647; P:regulation of protein stability; IMP:UniProtKB.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR005937; 26S_Psome_P45-like.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_C.
DR InterPro; IPR035263; PSMC6.
DR PANTHER; PTHR23073:SF76; PTHR23073:SF76; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01242; 26Sp45; 1.
DR PROSITE; PS00674; AAA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus;
KW Proteasome; Reference proteome.
FT CHAIN 1..406
FT /note="Probable 26S proteasome regulatory subunit 10B"
FT /id="PRO_0000084735"
FT BINDING 191..198
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..8
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015558"
SQ SEQUENCE 406 AA; 45859 MW; DCD706704840F529 CRC64;
MLLLQFSNMV EPTGPAIVED ERTKALNSYR RKLAECRDIE QKLKDLRKKE SEMTKQFDKS
ENDIKSLQSV GQIVGEVLKQ LSEEKFIVKA TNGPRYVVGC RRSINKEELK QGTRVSLDMT
TLTIMRQLPR EVDPLVYKMS HEDPGNISYS DVGGLAEQIR ELREVVELPL INPELFKRVG
ITPPKGCLLF GPPGTGKTLL ARAVASQLDC NFLKVVSSAI VDKYIGESAR MIREMFNYAR
DHQPCIVFMD EIDAIGGRRF SEGTSADREI QRTLMELLNQ LDGFDSLGKV KVIMATNRPD
TLDPALLRPG RLDRKIEIGL PNEQSRLEIL KIHSNKITKH GEIDFEAVVK LSDGFSAADL
RNVCTEAGMF AIRAEREFVI DEDFMKAVRK VGDAKRLETK LDYKPV
