ID   ATG33_VANPO             Reviewed;         204 AA.
AC   A7THN6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Autophagy-related protein 33;
GN   Name=ATG33; ORFNames=Kpol_543p32;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in the selective degradation of mitochondria via
CC       autophagy during starvation and at post-log phase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ATG33 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS480392; EDO18202.1; -; Genomic_DNA.
DR   RefSeq; XP_001646060.1; XM_001646010.1.
DR   AlphaFoldDB; A7THN6; -.
DR   STRING; 436907.A7THN6; -.
DR   EnsemblFungi; EDO18202; EDO18202; Kpol_543p32.
DR   GeneID; 5546477; -.
DR   KEGG; vpo:Kpol_543p32; -.
DR   eggNOG; ENOG502S27M; Eukaryota.
DR   HOGENOM; CLU_105986_1_0_1; -.
DR   InParanoid; A7THN6; -.
DR   OMA; HLACVIG; -.
DR   OrthoDB; 1602676at2759; -.
DR   PhylomeDB; A7THN6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..204
FT                   /note="Autophagy-related protein 33"
FT                   /id="PRO_0000399768"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   204 AA;  21492 MW;  A0028578BFA0BF0B CRC64;
     MSVCLGVTKT IAVSSLGLYA GLLTTTTLVT ASAPIDLLLP RTNENPIVNY FKSIVCSVGK
     ISTVLSGLST IFFGASYFGS PLSLRHPYLI YGMVIAPISA AYLYGASLFA HRHPSADQEK
     NNSPSPALDD STVDLGKDFK HPKITPGEAG KCPFGSKTSI EASSESSRKN CNASIVAHLS
     VVTVFTILGF VQSVVGLYGE GHFV