ID   PRS23_BOVIN             Reviewed;         375 AA.
AC   Q1LZE9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Serine protease 23;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=PRSS23;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}.
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DR   EMBL; BC116042; AAI16043.1; -; mRNA.
DR   RefSeq; NP_001073775.1; NM_001080306.1.
DR   RefSeq; XP_005226732.1; XM_005226675.3.
DR   AlphaFoldDB; Q1LZE9; -.
DR   STRING; 9913.ENSBTAP00000020194; -.
DR   PaxDb; Q1LZE9; -.
DR   Ensembl; ENSBTAT00000020194; ENSBTAP00000020194; ENSBTAG00000015177.
DR   GeneID; 538575; -.
DR   KEGG; bta:538575; -.
DR   CTD; 11098; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015177; -.
DR   VGNC; VGNC:33416; PRSS23.
DR   eggNOG; ENOG502QV0K; Eukaryota.
DR   GeneTree; ENSGT00390000000155; -.
DR   HOGENOM; CLU_055829_0_0_1; -.
DR   InParanoid; Q1LZE9; -.
DR   OMA; RQQQKWE; -.
DR   OrthoDB; 1245017at2759; -.
DR   TreeFam; TF329011; -.
DR   Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-BTA-8957275; Post-translational protein phosphorylation.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000015177; Expressed in prostate gland and 105 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW   Secreted; Serine protease; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..375
FT                   /note="Serine protease 23"
FT                   /id="PRO_0000299364"
FT   ACT_SITE        168
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   ACT_SITE        232
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   ACT_SITE        308
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        153..169
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   375 AA;  42446 MW;  F60855401F76A366 CRC64;
     MAGTPGHPIF LLLLLRAIGQ VSPYSTHWKP TWPAYRLPVV LPQSTFNLAK PDFGAEAKLE
     VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYVLRSGE EQSSGKSRRK
     RQIYGYDSRF SIFGKDFLLN YPFSTSVKLS TGCTGTLVAE KHVLTAAHCI HDGKTYVKGT
     QKLRVGFLKP KFKDGRGAND SHSALPEKMK FQWIRVKRTH VPKGWIKGNA NDIGMDYDYA
     LLELKKPHKR KFMKIGVSPP AKQLPGGRIH FSGYDNDRPG NLVYRFCDVQ DETYDLLYQQ
     CDAQPGASGS GVYVRMWKRQ QQKWERKIIG IFSGHQWVDV NGSPQDFNVA VRITPLKYAQ
     ICYWIKGNYV DCREG