ID   PRS23_RAT               Reviewed;         383 AA.
AC   Q6AY61;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Serine protease 23;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=Prss23;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}.
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DR   EMBL; BC079179; AAH79179.1; -; mRNA.
DR   RefSeq; NP_001007692.1; NM_001007691.1.
DR   AlphaFoldDB; Q6AY61; -.
DR   STRING; 10116.ENSRNOP00000023239; -.
DR   GlyGen; Q6AY61; 2 sites.
DR   iPTMnet; Q6AY61; -.
DR   PhosphoSitePlus; Q6AY61; -.
DR   PaxDb; Q6AY61; -.
DR   PRIDE; Q6AY61; -.
DR   Ensembl; ENSRNOT00000095166; ENSRNOP00000084133; ENSRNOG00000017307.
DR   GeneID; 308807; -.
DR   KEGG; rno:308807; -.
DR   UCSC; RGD:1359545; rat.
DR   CTD; 11098; -.
DR   RGD; 1359545; Prss23.
DR   eggNOG; ENOG502QTW6; Eukaryota.
DR   GeneTree; ENSGT00390000000155; -.
DR   HOGENOM; CLU_055829_0_0_1; -.
DR   InParanoid; Q6AY61; -.
DR   PhylomeDB; Q6AY61; -.
DR   TreeFam; TF329011; -.
DR   Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-RNO-8957275; Post-translational protein phosphorylation.
DR   PRO; PR:Q6AY61; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000017307; Expressed in stomach and 20 other tissues.
DR   ExpressionAtlas; Q6AY61; baseline and differential.
DR   Genevisible; Q6AY61; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW   Secreted; Serine protease; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..383
FT                   /note="Serine protease 23"
FT                   /id="PRO_0000299363"
FT   ACT_SITE        175
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   ACT_SITE        240
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   ACT_SITE        316
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10078"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        160..176
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   383 AA;  43160 MW;  4AB12CC7B66CDFC8 CRC64;
     MAGIPGLLIL LLVLLCVFMQ VSPYNVPWKP TWPAYRLPIV LPQSTLKLAK PDFDAKAKLE
     VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSNGE GRARSRDSEA
     AGKSRRKRQI YGYDGRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG
     KTYVKGTQKL RVGFLKPKYK DGAGGDNSSS SALVEKMKFQ WIRVKRTHVP KGWIKGNAND
     IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
     TYDLLYQQCD AQPGASGSGV YVRMWKRPQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR
     ITPLKYAQIC YWIKGNYLDC REG