ID   PRS2_METJA              Reviewed;         371 AA.
AC   Q58889;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative 26S proteasome regulatory subunit homolog MJ1494;
GN   OrderedLocusNames=MJ1494;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC       degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC       complex confers ATP dependency and substrate specificity to the 26S
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99505.1; -; Genomic_DNA.
DR   RefSeq; WP_010871017.1; NC_000909.1.
DR   AlphaFoldDB; Q58889; -.
DR   SMR; Q58889; -.
DR   STRING; 243232.MJ_1494; -.
DR   PRIDE; Q58889; -.
DR   EnsemblBacteria; AAB99505; AAB99505; MJ_1494.
DR   GeneID; 1452401; -.
DR   KEGG; mja:MJ_1494; -.
DR   eggNOG; arCOG04163; Archaea.
DR   HOGENOM; CLU_000688_21_3_2; -.
DR   InParanoid; Q58889; -.
DR   OMA; FGEWAPK; -.
DR   OrthoDB; 41252at2157; -.
DR   PhylomeDB; Q58889; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0036402; F:proteasome-activating activity; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Proteasome; Reference proteome.
FT   CHAIN           1..371
FT                   /note="Putative 26S proteasome regulatory subunit homolog
FT                   MJ1494"
FT                   /id="PRO_0000084754"
FT   BINDING         161..168
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   371 AA;  42167 MW;  01903F231167E85E CRC64;
     MSKIGFNPIK IKSFSKIKTY DDTLPSLKYV VLEPAGFPIR VSSENVKVST DDPILFNIYA
     RDQWIGEIVK EGDYLFDNSI LPDYAFKVIS TYPKEGGMIT SETVFKLQTP KKVLRTQFKK
     AKFSEIIGQE EAKKKCRIIM KYLENPKLFG EWAPKNVLFY GPPGTGKTLM ARALATETNS
     SFILVKAPEL IGEHVGDASK MIRELYQRAS ESAPCIVFID ELDAIGLSRE YQSLRGDVSE
     VVNALLTELD GIKENEGVVT IAATNNPAML DPAIRSRFEE EIEFKLPNDE ERLKIMELYA
     KKMPLPVKAN LKEFVEKTKG FSGRDIKEKF LKPALHRAIL EDRDYVSKED LEWALKKILG
     NRREAPQHLY L