ID   PRS2_METTH              Reviewed;         372 AA.
AC   O27092;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Putative 26S proteasome regulatory subunit homolog MTH_1011;
GN   OrderedLocusNames=MTH_1011;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC       degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC       complex confers ATP dependency and substrate specificity to the 26S
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85507.1; -; Genomic_DNA.
DR   PIR; H69001; H69001.
DR   AlphaFoldDB; O27092; -.
DR   SMR; O27092; -.
DR   STRING; 187420.MTH_1011; -.
DR   EnsemblBacteria; AAB85507; AAB85507; MTH_1011.
DR   KEGG; mth:MTH_1011; -.
DR   PATRIC; fig|187420.15.peg.994; -.
DR   HOGENOM; CLU_000688_21_3_2; -.
DR   OMA; FGEWAPK; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR000641; CbxX/CfxQ.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   PRINTS; PR00819; CBXCFQXSUPER.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Proteasome; Reference proteome.
FT   CHAIN           1..372
FT                   /note="Putative 26S proteasome regulatory subunit homolog
FT                   MTH_1011"
FT                   /id="PRO_0000084755"
FT   BINDING         164..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   372 AA;  42599 MW;  4A6F03002E5745C2 CRC64;
     MVKFNNIIYD PQVSDKKFPV QASDPEREAK LVVLQPVGYP FVCNLMEAPR IDAVNKELFE
     IYARDQWEGF RAAEGSYLFD QKLLPDYAFK IIRAHPDGSK ITRNTSIILL ENDREEFHEV
     RSSITMDDVI GQEDAKIKCR IIMKYLEDPD RFRDWAPRNV LFHGSPGTGK TMLAKSLANE
     LKVPLYLIKA TSLIGEHVGD GARQIHELYE LASKTAPSVI FIDEMDAIGL DRRYQSLRGD
     VSEVVNALLT EMDGINQNWG VVTIGATNNP ELLDKAIRSR FEEEIEFKLP DDEERKLMLE
     KYIETMPLKV DFPVDKLVKL TREMSGRDIK DRVLKTALHR AIAEDSESVR AEHIEYALKE
     RKVSGEPKHM FA