ID   PRS35_BOVIN             Reviewed;         412 AA.
AC   Q5E9X7; Q3B7L4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Inactive serine protease 35;
DE   Flags: Precursor;
GN   Name=PRSS35;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}.
CC   -!- CAUTION: Although related to peptidase S1 family, lacks the conserved
CC       active Ser residue in position 345 which is replaced by a Thr,
CC       suggesting that it has no protease activity. {ECO:0000305}.
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DR   EMBL; BT020793; AAX08810.1; -; mRNA.
DR   EMBL; BC107557; AAI07558.1; -; mRNA.
DR   RefSeq; NP_001030534.3; NM_001035457.3.
DR   RefSeq; XP_005210754.1; XM_005210697.3.
DR   AlphaFoldDB; Q5E9X7; -.
DR   STRING; 9913.ENSBTAP00000037916; -.
DR   MEROPS; S01.994; -.
DR   PaxDb; Q5E9X7; -.
DR   PRIDE; Q5E9X7; -.
DR   Ensembl; ENSBTAT00000068329; ENSBTAP00000069102; ENSBTAG00000052055.
DR   GeneID; 614940; -.
DR   KEGG; bta:614940; -.
DR   CTD; 167681; -.
DR   VEuPathDB; HostDB:ENSBTAG00000052055; -.
DR   VGNC; VGNC:33418; PRSS35.
DR   eggNOG; ENOG502QV0K; Eukaryota.
DR   GeneTree; ENSGT00390000000155; -.
DR   HOGENOM; CLU_055829_0_0_1; -.
DR   InParanoid; Q5E9X7; -.
DR   OMA; MEQDFMW; -.
DR   OrthoDB; 1245017at2759; -.
DR   TreeFam; TF329011; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000052055; Expressed in myometrium and 74 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.10.10; -; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Serine protease homolog; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..412
FT                   /note="Inactive serine protease 35"
FT                   /id="PRO_0000299357"
FT   DOMAIN          124..407
FT                   /note="Peptidase S1"
FT   REGION          192..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..206
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..229
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        154..170
FT                   /evidence="ECO:0000250"
FT   CONFLICT        162
FT                   /note="N -> T (in Ref. 1; AAX08810)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        268
FT                   /note="R -> G (in Ref. 1; AAX08810)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   412 AA;  46537 MW;  0B2A43323BCA69B7 CRC64;
     MGAMFFGLML FTLGWTLIDG SESEQDFMWH VRKIPRLVSE RTFHLTSPAF EADAKMVLNR
     VCGIECQKDL PAPSLSDLED SLSYETVFEN GSRTLTRVKV QGWVPEPTQN LTSQGAPVRR
     KRQVYGTDSR FSILDKKFLT NFPFNTAVKL STGCSGILIS PNHVLTAAHC VHDGNGYIKG
     SKKLRVGLLK MRNKGGGKRR RGSRRNRREV SGAGREGSQD SLKETAKAGR RRKGSARRQR
     AADGRPSFQW TRVKNTHIPK GWARGESRDP ALDYDYALLE LKRPHKKKYM ELGVSPTIKK
     LPGGMIHFSG FDQDRADQLV YRFCSVSDES NDLLYQYCDA ESGSTGSGVY LRLKEPDKKR
     WKRKIIAIYS GHQWVDVHGV QKDYNVAVRI TPLKYAQICL WMHGDDANCT QG