PRS38_MOUSE
ID PRS38_MOUSE Reviewed; 322 AA.
AC Q3UKY7; B9EJM8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Serine protease 38;
DE EC=3.4.21.-;
DE AltName: Full=Marapsin-2;
DE Flags: Precursor;
GN Name=Prss38; Synonyms=Gm249, Mpn2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AK145810; BAE26664.1; -; mRNA.
DR EMBL; BC147400; AAI47401.1; -; mRNA.
DR EMBL; BC147401; AAI47402.1; -; mRNA.
DR CCDS; CCDS36170.1; -.
DR RefSeq; NP_001038986.1; NM_001045521.1.
DR AlphaFoldDB; Q3UKY7; -.
DR SMR; Q3UKY7; -.
DR STRING; 10090.ENSMUSP00000052010; -.
DR MEROPS; S01.324; -.
DR GlyGen; Q3UKY7; 3 sites.
DR PhosphoSitePlus; Q3UKY7; -.
DR PaxDb; Q3UKY7; -.
DR PRIDE; Q3UKY7; -.
DR ProteomicsDB; 291903; -.
DR Antibodypedia; 20773; 30 antibodies from 11 providers.
DR DNASU; 216797; -.
DR Ensembl; ENSMUST00000061481; ENSMUSP00000052010; ENSMUSG00000049291.
DR GeneID; 216797; -.
DR KEGG; mmu:216797; -.
DR UCSC; uc007jdr.1; mouse.
DR CTD; 339501; -.
DR MGI; MGI:2685095; Prss38.
DR VEuPathDB; HostDB:ENSMUSG00000049291; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000154494; -.
DR HOGENOM; CLU_006842_0_4_1; -.
DR InParanoid; Q3UKY7; -.
DR OMA; TACEGDS; -.
DR OrthoDB; 1314811at2759; -.
DR PhylomeDB; Q3UKY7; -.
DR TreeFam; TF351676; -.
DR BioGRID-ORCS; 216797; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q3UKY7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3UKY7; protein.
DR Bgee; ENSMUSG00000049291; Expressed in spermatocyte and 9 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Secreted; Serine protease; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT PROPEP 29..55
FT /note="Activation peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000328822"
FT CHAIN 56..322
FT /note="Serine protease 38"
FT /id="PRO_0000328823"
FT DOMAIN 56..289
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 96
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 146
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 241
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 81..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 179..247
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 210..226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 237..265
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ SEQUENCE 322 AA; 35698 MW; 0073C08E70FFF674 CRC64;
MAALTSGLGV LGYLLFPLLL ASPTWVTSVS RRHPKSQANS LSGDVACGQP VLQGKLLGGE
FARDRKWPWQ VSLHYSGFHI CGGSILSAYW VLSAAHCFDR GKKLETYDIY VGITNLEKAN
RHTQWFEIYQ VIIHPTFQMY HPIGGDVALV QLKSAIVFSD FVLPICLPPS DLYLINLSCW
TTGWGMISPQ GETGNELLEA QLPLIPRFQC QLLYGLSSYL LPEMLCAADI KTMKNVCEGD
SGSPLVCKQN QTWLQIGIVS WGRGCAQPLY PGVFANVSYF LSWIRYHLQI IPNPPQILPS
LSSSPKNTLI IFVTIMGHLL VL
