PRS45_HUMAN
ID PRS45_HUMAN Reviewed; 260 AA.
AC Q7RTY3; A3KN77;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Putative serine protease 45 {ECO:0000305};
DE EC=3.4.21.-;
DE AltName: Full=Serine protease 45, pseudogene {ECO:0000305};
DE AltName: Full=Testis serine protease 5;
GN Name=PRSS45P {ECO:0000312|HGNC:HGNC:30717};
GN Synonyms=PRSS45 {ECO:0000312|HGNC:HGNC:30717}, TESSP5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=12838346; DOI=10.1038/nrg1111;
RA Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.;
RT "Human and mouse proteases: a comparative genomic approach.";
RL Nat. Rev. Genet. 4:544-558(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7RTY3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7RTY3-2; Sequence=VSP_035355;
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC134504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133695; AAI33696.1; -; mRNA.
DR EMBL; BN000137; CAD68171.1; -; mRNA.
DR RefSeq; NP_954652.2; NM_199183.2.
DR AlphaFoldDB; Q7RTY3; -.
DR SMR; Q7RTY3; -.
DR BioGRID; 132016; 6.
DR IntAct; Q7RTY3; 2.
DR MEROPS; S01.326; -.
DR GlyGen; Q7RTY3; 1 site.
DR BioMuta; PRSS45; -.
DR DMDM; 74759052; -.
DR MassIVE; Q7RTY3; -.
DR PeptideAtlas; Q7RTY3; -.
DR PRIDE; Q7RTY3; -.
DR Antibodypedia; 53159; 29 antibodies from 10 providers.
DR Ensembl; ENST00000620911.6; ENSP00000499994.1; ENSG00000188086.15. [Q7RTY3-1]
DR UCSC; uc010hjl.4; human. [Q7RTY3-1]
DR GeneCards; PRSS45P; -.
DR HGNC; HGNC:30717; PRSS45P.
DR HPA; ENSG00000188086; Tissue enhanced (epididymis, skeletal muscle).
DR neXtProt; NX_Q7RTY3; -.
DR VEuPathDB; HostDB:ENSG00000188086; -.
DR GeneTree; ENSGT00940000161932; -.
DR HOGENOM; CLU_006842_0_4_1; -.
DR InParanoid; Q7RTY3; -.
DR OMA; PWEVSLQ; -.
DR OrthoDB; 1314811at2759; -.
DR PhylomeDB; Q7RTY3; -.
DR TreeFam; TF351676; -.
DR PathwayCommons; Q7RTY3; -.
DR SignaLink; Q7RTY3; -.
DR BioGRID-ORCS; 377047; 6 hits in 1063 CRISPR screens.
DR GenomeRNAi; 377047; -.
DR Pharos; Q7RTY3; Tdark.
DR PRO; PR:Q7RTY3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7RTY3; protein.
DR Bgee; ENSG00000188086; Expressed in left lobe of thyroid gland and 77 other tissues.
DR ExpressionAtlas; Q7RTY3; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 5: Uncertain;
KW Alternative splicing; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW Reference proteome; Serine protease.
FT CHAIN 1..260
FT /note="Putative serine protease 45"
FT /id="PRO_0000349307"
FT DOMAIN 1..234
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 34
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 82
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 186
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 19..35
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 116..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 151..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 182..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT VAR_SEQ 96..129
FT /note="EYVQPICLPEPNFNLKVGTQCWVTGWSQVKQRFS -> ST (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035355"
SQ SEQUENCE 260 AA; 29329 MW; CE55C4CD62F541AA CRC64;
MTRHWPWEVS LRMENEHVCG GALIDPSWVV TAAHCIQGTK EYSVVLGTSK LQPMNFSRAL
WVPVRDIIMH PKYWGRAFIM GDVALVHLQT PVTFSEYVQP ICLPEPNFNL KVGTQCWVTG
WSQVKQRFSA NSMLTPELQE AEVFIMDNKR CDRHYKKSFF PPVVPLVLGD MICATNYGEN
LCYGDSGGPL ACEVEGRWIL AGVLSWEKAC VKAQNPGVYT RITKYTKWIK KQMSNGAFSG
PCASACLLFL CWLLQPQMGS
