PRS46_HUMAN
ID PRS46_HUMAN Reviewed; 174 AA.
AC E5RG02;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Putative serine protease 46;
DE EC=3.4.21.-;
DE AltName: Full=Serine protease 46 pseudogene {ECO:0000312|HGNC:HGNC:37325};
GN Name=PRSS46P {ECO:0000312|HGNC:HGNC:37325}; Synonyms=PRSS46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AC134504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001192200.1; NM_001205271.1.
DR AlphaFoldDB; E5RG02; -.
DR SMR; E5RG02; -.
DR BioGRID; 939023; 1.
DR STRING; 9606.ENSP00000430307; -.
DR MEROPS; S01.394; -.
DR BioMuta; PRSS46; -.
DR MassIVE; E5RG02; -.
DR PaxDb; E5RG02; -.
DR PeptideAtlas; E5RG02; -.
DR PRIDE; E5RG02; -.
DR UCSC; uc021wxf.2; human.
DR GeneCards; PRSS46P; -.
DR HGNC; HGNC:37325; PRSS46P.
DR neXtProt; NX_E5RG02; -.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_006842_1_7_1; -.
DR InParanoid; E5RG02; -.
DR PhylomeDB; E5RG02; -.
DR PathwayCommons; E5RG02; -.
DR BioGRID-ORCS; 100287362; 10 hits in 1058 CRISPR screens.
DR GenomeRNAi; 100287362; -.
DR Pharos; E5RG02; Tdark.
DR PRO; PR:E5RG02; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; E5RG02; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hydrolase; Protease; Reference proteome; Serine protease.
FT CHAIN 1..174
FT /note="Putative serine protease 46"
FT /id="PRO_0000418332"
FT DOMAIN 43..174
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 83
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 128
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT DISULFID 68..84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ SEQUENCE 174 AA; 19341 MW; C81897F137B09408 CRC64;
MACGPGDLQS LTSPLSSARL DYQPSIEGPW LRACGQTNVS CRVVKGKLVE VGKWPWQVSI
LFLGTYICSG SLIHHQWVLT AAHCLQRFKD LSLYSVMVGV HQRPENSTQL PLTRMVIHKD
FSNLMSQDIA LLKLRDSISW SPFVQPVCLP NIKFKPSIGS MCWVIGWGTT GKKG
