PRS4_ORYSJ
ID PRS4_ORYSJ Reviewed; 448 AA.
AC P46466; Q0D3E0; Q84NR0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=26S proteasome regulatory subunit 4 homolog;
DE AltName: Full=Tat-binding protein homolog 2;
GN Name=TBP2; OrderedLocusNames=Os07g0691800, LOC_Os07g49150;
GN ORFNames=P0034A04.112;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Nipponbare; TISSUE=Callus;
RA Suzuka I., Koga-Ban Y., Sasaki T., Minobe Y., Hashimoto J.;
RT "Identification of cDNA clones for rice homologs of the human
RT immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S
RT protease (proteasome).";
RL Plant Sci. 103:33-40(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC complex confers ATP dependency and substrate specificity to the 26S
CC complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; D17789; BAA04615.1; -; mRNA.
DR EMBL; AP004333; BAC75555.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF22633.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT03341.1; -; Genomic_DNA.
DR EMBL; AK058311; BAG86657.1; -; mRNA.
DR EMBL; AK099264; BAG94028.1; -; mRNA.
DR EMBL; AK105861; BAG97398.1; -; mRNA.
DR PIR; T03776; T03776.
DR RefSeq; XP_015647425.1; XM_015791939.1.
DR AlphaFoldDB; P46466; -.
DR SMR; P46466; -.
DR BioGRID; 813410; 1.
DR STRING; 4530.OS07T0691800-01; -.
DR PaxDb; P46466; -.
DR PRIDE; P46466; -.
DR EnsemblPlants; Os07t0691800-01; Os07t0691800-01; Os07g0691800.
DR GeneID; 4344373; -.
DR Gramene; Os07t0691800-01; Os07t0691800-01; Os07g0691800.
DR KEGG; osa:4344373; -.
DR eggNOG; KOG0726; Eukaryota.
DR HOGENOM; CLU_000688_2_3_1; -.
DR InParanoid; P46466; -.
DR OMA; YCPLHIT; -.
DR OrthoDB; 571919at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR ExpressionAtlas; P46466; baseline and differential.
DR Genevisible; P46466; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0036402; F:proteasome-activating activity; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR005937; 26S_Psome_P45-like.
DR InterPro; IPR035244; 26S_subunit_4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_C.
DR PANTHER; PTHR23073:SF116; PTHR23073:SF116; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01242; 26Sp45; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome;
KW Reference proteome.
FT CHAIN 1..448
FT /note="26S proteasome regulatory subunit 4 homolog"
FT /id="PRO_0000084683"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 234..241
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 35
FT /note="P -> S (in Ref. 1; BAA04615)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 448 AA; 49587 MW; 126C1311327DA390 CRC64;
MGQGTPGGMG KQGGAPGDRK PGGDGDKKDR KFEPPAAPSR VGRKQRKQKG PEAAARLPNV
APLSKCRLRL LKLERVKDYL LMEEEFVAAQ ERLRPTEDKT EEDRSKVDDL RGTPMSVGSL
EEIIDESHAI VSSSVGPEYY VGILSFVDKD QLEPGCSILM HNKVLSVVGI LQDEVDPMVS
VMKVEKAPLE SYADIGGLDA QIQEIKEAVE LPLTHPELYE DIGIRPPKGV ILYGEPGTGK
TLLAKAVANS TSATFLRVVG SELIQKYLGD GPKLVRELFR VADELSPSIV FIDEIDAVGT
KRYDAHSGGE REIQRTMLEL LNQLDGFDSR GDVKVILATN RIESLDPALL RPGRIDRKIE
FPLPDIKTRR RIFQIHTSKM TLADDVNLEE FVMTKDEFSG ADIKAICTEA GLLALRERRM
KVTHADFKKA KEKVMFKKKE GVPEGLYM
