PRS51_HUMAN
ID PRS51_HUMAN Reviewed; 220 AA.
AC A0A1B0GVH4;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2016, sequence version 1.
DT 03-AUG-2022, entry version 26.
DE RecName: Full=Serine protease-like protein 51 {ECO:0000305};
DE Flags: Precursor;
GN Name=PRSS51 {ECO:0000312|HGNC:HGNC:37321};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
CC -!- CAUTION: Lacks essential residues of the catalytic triad and is
CC therefore predicted to have no protease activity. {ECO:0000305}.
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DR EMBL; AC104964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0GVH4; -.
DR GlyGen; A0A1B0GVH4; 2 sites.
DR PhosphoSitePlus; A0A1B0GVH4; -.
DR BioMuta; PRSS51; -.
DR jPOST; A0A1B0GVH4; -.
DR MassIVE; A0A1B0GVH4; -.
DR PeptideAtlas; A0A1B0GVH4; -.
DR Ensembl; ENST00000636217.1; ENSP00000490515.1; ENSG00000253649.5.
DR GeneCards; PRSS51; -.
DR HGNC; HGNC:37321; PRSS51.
DR HPA; ENSG00000253649; Tissue enriched (brain).
DR neXtProt; NX_A0A1B0GVH4; -.
DR OpenTargets; ENSG00000253649; -.
DR VEuPathDB; HostDB:ENSG00000253649; -.
DR GeneTree; ENSGT00940000156020; -.
DR ChiTaRS; PRSS51; human.
DR Pharos; A0A1B0GVH4; Tdark.
DR PRO; PR:A0A1B0GVH4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; A0A1B0GVH4; protein.
DR Bgee; ENSG00000253649; Expressed in right hemisphere of cerebellum and 93 other tissues.
DR ExpressionAtlas; A0A1B0GVH4; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR Pfam; PF00089; Trypsin; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..220
FT /note="Serine protease-like protein 51"
FT /evidence="ECO:0000255"
FT /id="PRO_5008408658"
FT DOMAIN 23..220
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 64..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 157..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ SEQUENCE 220 AA; 25576 MW; FC84299A348126D2 CRC64;
MFQLLIPLLL ALKGHAQDNP ENVQCGHRPA FPNSSWLPFH ERLQVQNGEC PWQVSIQMSR
KHLCGGSILH WWWVLTAAHC FRRTLLDMAV VNVTVVMGTR TFSNIHSERK QVQKEEERTW
DWCWMAQWVT TNGYDQYDDL NMHLEKLRVV QISRKECAKR INQLSRNMIC AWNEPGTNGI
FKVLTPAQPP PPSRETVGHL WFVLFMEPRD SSKWVSSVGA
