ID   PRS54_RAT               Reviewed;         382 AA.
AC   Q6AY28;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Inactive serine protease 54;
DE   AltName: Full=Plasma kallikrein-like protein 4;
DE   Flags: Precursor;
GN   Name=Prss54; Synonyms=Klkbl4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 118-124, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA   Lubec G., Chen W.-Q.;
RL   Submitted (APR-2007) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Plasma kallikrein
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- CAUTION: Although related to peptidase S1 family, lacks the essential
CC       His, Asp, and Ser residues of the catalytic triad at positions 73, 119
CC       and 210 and is therefore predicted to have lost protease activity.
CC       {ECO:0000305}.
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DR   EMBL; BC079217; AAH79217.1; -; mRNA.
DR   RefSeq; NP_001013910.1; NM_001013888.1.
DR   RefSeq; XP_008770495.1; XM_008772273.2.
DR   AlphaFoldDB; Q6AY28; -.
DR   SMR; Q6AY28; -.
DR   STRING; 10116.ENSRNOP00000036855; -.
DR   MEROPS; S01.992; -.
DR   GlyGen; Q6AY28; 1 site.
DR   PaxDb; Q6AY28; -.
DR   Ensembl; ENSRNOT00000033953; ENSRNOP00000036855; ENSRNOG00000023092.
DR   GeneID; 291846; -.
DR   KEGG; rno:291846; -.
DR   UCSC; RGD:1307877; rat.
DR   CTD; 221191; -.
DR   RGD; 1307877; Prss54.
DR   eggNOG; KOG3627; Eukaryota.
DR   GeneTree; ENSGT01020000230389; -.
DR   HOGENOM; CLU_058835_0_0_1; -.
DR   InParanoid; Q6AY28; -.
DR   OMA; LVQPICF; -.
DR   OrthoDB; 1314811at2759; -.
DR   PhylomeDB; Q6AY28; -.
DR   TreeFam; TF338267; -.
DR   PRO; PR:Q6AY28; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000023092; Expressed in testis.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Serine protease homolog; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..382
FT                   /note="Inactive serine protease 54"
FT                   /id="PRO_0000288802"
FT   DOMAIN          29..258
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        154..216
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        185..195
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        206..237
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ   SEQUENCE   382 AA;  42921 MW;  5E24760879834BF1 CRC64;
     MAELRGILLL LLYMSHSSSA ICGIQKANIV DQLHENLVSS TEFPWVVSIQ DKQYTHLAFG
     CILSEFWILS TASALQNRKE VIAVVGIANM DPRNADHKEY SINAIIPHEN FNNNSMRNNI
     ALLRTDSAIH FDDLVQPICF LGKSLHKPTA LKNCWVAGWN PTSATGNHMT MSILRRISVN
     DIEVCPLHRQ QKTECASHTN KDSNVCLGEP GNPMMCQVKK LDLWILRGLL AYGSDLCPGL
     LLYTSVDDYS NWIIAKTRKA GPPLSSIHPW EKLVLELPFH QSNIALTKNS YSVHSYAWPQ
     SYSQGLRMST MYDKQKDVWQ NLRVNGQQEA GRPSNVAIQP MYYDYYGGEA GEGRAVAGQN
     RLHWSQERIL MSFVLVFLGS GV