ID   ATG35_KOMPG             Reviewed;         463 AA.
AC   C4QVX6;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Autophagy-related protein 36;
GN   Name=ATG35; OrderedLocusNames=PAS_chr1-1_0041;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
RN   [2]
RP   INTERACTION WITH ATG28, FUNCTION, AND INDUCTION.
RX   PubMed=21169734; DOI=10.4161/auto.7.4.14369;
RA   Nazarko V.Y., Nazarko T.Y., Farre J.C., Stasyk O.V., Warnecke D.,
RA   Ulaszewski S., Cregg J.M., Sibirny A.A., Subramani S.;
RT   "Atg35, a micropexophagy-specific protein that regulates micropexophagic
RT   apparatus formation in Pichia pastoris.";
RL   Autophagy 7:375-385(2011).
CC   -!- FUNCTION: Micropexophagy-specific protein required for efficient
CC       micropexophagic apparatus (MIPA) formation but not for general
CC       autophagy. {ECO:0000269|PubMed:21169734}.
CC   -!- SUBUNIT: Interacts with ATG28. {ECO:0000269|PubMed:21169734}.
CC   -!- INDUCTION: Expression is induced by methanol and glucose.
CC       {ECO:0000269|PubMed:21169734}.
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DR   EMBL; FN392319; CAY67399.1; -; Genomic_DNA.
DR   RefSeq; XP_002489680.1; XM_002489635.1.
DR   AlphaFoldDB; C4QVX6; -.
DR   STRING; 644223.C4QVX6; -.
DR   PRIDE; C4QVX6; -.
DR   EnsemblFungi; CAY67399; CAY67399; PAS_chr1-1_0041.
DR   GeneID; 8197558; -.
DR   KEGG; ppa:PAS_chr1-1_0041; -.
DR   eggNOG; KOG0825; Eukaryota.
DR   HOGENOM; CLU_606994_0_0_1; -.
DR   InParanoid; C4QVX6; -.
DR   OMA; IPSQYII; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR018527; Rubredoxin_Fe_BS.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS00202; RUBREDOXIN; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 2.
PE   1: Evidence at protein level;
KW   Autophagy; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..463
FT                   /note="Autophagy-related protein 36"
FT                   /id="PRO_0000422170"
FT   ZN_FING         5..45
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         85..131
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          229..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  53341 MW;  9D61A1B551D312A7 CRC64;
     MEEVCSICLE VLVDKEAFTE PCLHYYHNEC IKEWTKRANT CPKCRRDYSQ IRIGEEVISV
     KNRSLELHLV DETLEETRER LISYTNLCAL CEDPSTSLIY CESCGGSFHF NCIGIGDELD
     SEWCCPLCGM FQNHLGEASN RNLISATPVG EGRRRVTSIV NTRRTNSIYR SHSNRPAQRA
     HLMTDSDYTM IVDQHREKLL ESQLQESNTQ SSGEEESWKL LDEALKSGTQ NSQSSEFSTE
     NNVVPLKNTH ELGRKLKKPR RASGIKKNVV ERSSSHQSTQ ILKPSSSLIS DLLLETRGNS
     RHPSFTNSTQ KLTVEALQSH DPTLKLNIPK TETLSLDQKI VIQKLFIKPR LRNLYDSNTL
     SKDNYIEINK IICRRLYDKF LQDQLALAYL KQVLEVKERL HGHDLKQFLA QFTHWSELND
     FTDDKWQKQE TEGSCNHKQT QILSMFDSII DTMLQNELHK LLT