ATG36_YEAST
ID ATG36_YEAST Reviewed; 293 AA.
AC P46983; D6VW05;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Autophagy-related protein 36;
GN Name=ATG36; OrderedLocusNames=YJL185C; ORFNames=J0415;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=17146497;
RA Boniewska-Bernacka E., Wysocki R., Grochowalska R., Machnicka B.,
RA Ulaszewski S., Lachowicz T.;
RT "The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are
RT probably involved in regulation of the glyoxylate cycle.";
RL Acta Biochim. Pol. 53:739-745(2006).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH PEX3; ATG8 AND ATG11.
RX PubMed=22643220; DOI=10.1038/emboj.2012.151;
RA Motley A.M., Nuttall J.M., Hettema E.H.;
RT "Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces
RT cerevisiae.";
RL EMBO J. 31:2852-2868(2012).
CC -!- FUNCTION: Required for autophagic breakdown of peroxisomes, called
CC pexophagy, through linking peroxisomes to the autophagy apparatus.
CC Involved in regulation of the glyoxylate cycle.
CC {ECO:0000269|PubMed:17146497, ECO:0000269|PubMed:22643220}.
CC -!- SUBUNIT: Interacts with PEX3, ATG8 and ATG11.
CC {ECO:0000269|PubMed:22643220}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:22643220}.
CC Note=Recruited to peroxisomes by PEX3.
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DR EMBL; Z49460; CAA89480.1; -; Genomic_DNA.
DR EMBL; AY558308; AAS56634.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08621.1; -; Genomic_DNA.
DR PIR; S56968; S56968.
DR RefSeq; NP_012350.1; NM_001181618.1.
DR AlphaFoldDB; P46983; -.
DR SMR; P46983; -.
DR BioGRID; 33577; 40.
DR DIP; DIP-1561N; -.
DR IntAct; P46983; 5.
DR MINT; P46983; -.
DR STRING; 4932.YJL185C; -.
DR iPTMnet; P46983; -.
DR PaxDb; P46983; -.
DR PRIDE; P46983; -.
DR EnsemblFungi; YJL185C_mRNA; YJL185C; YJL185C.
DR GeneID; 853254; -.
DR KEGG; sce:YJL185C; -.
DR SGD; S000003721; ATG36.
DR VEuPathDB; FungiDB:YJL185C; -.
DR eggNOG; ENOG502SEYA; Eukaryota.
DR HOGENOM; CLU_085157_0_0_1; -.
DR InParanoid; P46983; -.
DR OMA; HHERIFD; -.
DR BioCyc; YEAST:G3O-31619-MON; -.
DR PRO; PR:P46983; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P46983; protein.
DR GO; GO:0005777; C:peroxisome; IDA:SGD.
DR GO; GO:0030242; P:autophagy of peroxisome; IMP:SGD.
DR GO; GO:0000423; P:mitophagy; IMP:SGD.
PE 1: Evidence at protein level;
KW Autophagy; Peroxisome; Reference proteome.
FT CHAIN 1..293
FT /note="Autophagy-related protein 36"
FT /id="PRO_0000203020"
FT REGION 98..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 33740 MW; 2F1499AFFF3CCB9C CRC64;
MASVNNYQVD CGSRSARIQP RINNGIHDEE SLFEVLELSE EEFELDFHRL KSFNDVRVIN
NPDLSPECTN TAISRDETLE SASSAFEVPS DEIAILSISS DSNKNSPPSE QPAPALRNIR
SSSNSDRIDE WCLGSHLFNE LHQNVPQSSD GVNHGFPVYS FKERELYTSA KLKKLTNAQR
IAVQKLSRDL YPILRTCYRE KTRRQLLTYH HERIFDDIPS FFPQRDFIFN YYSMPLEFDR
LSDVDIDSSS RSRFTDESTG ETLNRSPSAA SSSLENTSWF GWTLLSRFLD REW
