PRS6A_ORYSJ
ID PRS6A_ORYSJ Reviewed; 429 AA.
AC P46465; Q0DWP6; Q69SI9; Q8W421;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=26S proteasome regulatory subunit 6A homolog;
DE AltName: Full=Tat-binding protein homolog 1;
DE Short=TBP-1;
GN Name=TBP1; Synonyms=OsRPT5a;
GN OrderedLocusNames=Os02g0803700, LOC_Os02g56000; ORFNames=P0689B12.30;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Nipponbare; TISSUE=Callus;
RA Suzuka I., Koga-Ban Y., Sasaki T., Minobe Y., Hashimoto J.;
RT "Identification of cDNA clones for rice homologs of the human
RT immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S
RT protease (proteasome).";
RL Plant Sci. 103:33-40(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11874462; DOI=10.1046/j.1432-1033.2002.02792.x;
RA Shibahara T., Kawasaki H., Hirano H.;
RT "Identification of the 19S regulatory particle subunits from the rice 26S
RT proteasome.";
RL Eur. J. Biochem. 269:1474-1483(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC complex confers ATP dependency and substrate specificity to the 26S
CC complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P46465-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P46465-2; Sequence=VSP_019502;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; D17788; BAA04614.1; -; mRNA.
DR EMBL; AB037155; BAB78492.1; -; mRNA.
DR EMBL; AP005056; BAD36042.1; -; Genomic_DNA.
DR EMBL; AP005056; BAD36043.1; -; Genomic_DNA.
DR EMBL; AP008208; BAF10342.1; -; Genomic_DNA.
DR EMBL; AP014958; BAS81442.1; -; Genomic_DNA.
DR EMBL; AK067051; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK103936; BAG96331.1; -; mRNA.
DR RefSeq; XP_015625151.1; XM_015769665.1. [P46465-1]
DR AlphaFoldDB; P46465; -.
DR SMR; P46465; -.
DR STRING; 4530.OS02T0803700-01; -.
DR PaxDb; P46465; -.
DR PRIDE; P46465; -.
DR EnsemblPlants; Os02t0803700-01; Os02t0803700-01; Os02g0803700. [P46465-1]
DR GeneID; 4331050; -.
DR Gramene; Os02t0803700-01; Os02t0803700-01; Os02g0803700. [P46465-1]
DR KEGG; osa:4331050; -.
DR eggNOG; KOG0652; Eukaryota.
DR HOGENOM; CLU_000688_2_4_1; -.
DR OMA; HEANCSF; -.
DR OrthoDB; 571919at2759; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR ExpressionAtlas; P46465; baseline and differential.
DR Genevisible; P46465; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0036402; F:proteasome-activating activity; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR005937; 26S_Psome_P45-like.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_C.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01242; 26Sp45; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus;
KW Proteasome; Reference proteome.
FT CHAIN 1..429
FT /note="26S proteasome regulatory subunit 6A homolog"
FT /id="PRO_0000084706"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 217..224
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..164
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_019502"
FT CONFLICT 29
FT /note="D -> N (in Ref. 1; BAA04614)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 47797 MW; 39602F0480A9EB08 CRC64;
MSSPPPAAAA AMAVDDADDD QLASMSTEDI VRATRLLDNE TRVLKDELQR TNLEVESYKE
KIKENQEKIK LNKQLPYLVG NIVEILEMNP EDEAEEDGAN IDLDSQRKGK CVVLKTSTRQ
TIFLPVIGLV DPEKLKPGDL VGVNKDSYLI LDTLPSEYDS RVKAMEVDEK PTEDYNDIGG
LEKQIQELVE AIVLPMTHKD RFQKLGIRPP KGVLLYGPPG TGKTLMARAC AAQTNATFLK
LAGPQLVQMF IGDGAKLVRD AFQLAKEKSP CIIFIDEIDA IGTKRFDSEV SGDREVQRTM
LELLNQLDGF SSDERIKVIA ATNRADILDP ALMRSGRLDR KIEFPHPSEE ARARILQIHS
RKMNVNPDVN FEELARSTDD FNGAQLKAVC VEAGMLALRR DATEVTHEDF NEGIIQVQAK
KKSSLNYYA
